Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy

An accurate and timely diagnosis for Alzheimer's disease (AD) is important, both for care and research. The current diagnostic criteria allow the use of CSF biomarkers to provide pathophysiological support for the diagnosis of AD. How these criteria should be operationalized by clinicians is un...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0226784-e0226784
Hauptverfasser:	Rhodius-Meester, Hanneke F M, van Maurik, Ingrid S, Koikkalainen, Juha, Tolonen, Antti, Frederiksen, Kristian S, Hasselbalch, Steen G, Soininen, Hilkka, Herukka, Sanna-Kaisa, Remes, Anne M, Teunissen, Charlotte E, Barkhof, Frederik, Pijnenburg, Yolande A L, Scheltens, Philip, Lötjönen, Jyrki, van der Flier, Wiesje M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Algorithms Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Alzheimer Disease - physiopathology Alzheimer's disease Apolipoprotein E Biology and Life Sciences Biomarkers Biomarkers - cerebrospinal fluid Brain research Cerebrospinal fluid Clinical decision making Clinical medicine Computer aided decision processes Computer aided testing Computer simulation Consent Criteria Decision making Decision support systems Decision Support Systems, Clinical Dementia Dementia disorders Demographics Diagnosis Diagnostic systems Disease control Epidemiology Family medical history Female Frontotemporal dementia Hospitals Humans Magnetic resonance imaging Male Medical diagnosis Medicine Medicine and Health Sciences Memory Middle Aged Neurodegenerative diseases Neurology Neurosciences Patient Selection Patients Research and Analysis Methods Sensitivity and Specificity Social Sciences Vascular dementia
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