Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study
It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored. We investigated whether patients with T1DM are at a relatively hi...
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| description | It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored.
We investigated whether patients with T1DM are at a relatively high risk of VTE development.
We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM.
During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60.
T1DM appears to be an independent risk factor for VTE development. |
| doi_str_mv | 10.1371/journal.pone.0226997 |
| format | Article |
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We investigated whether patients with T1DM are at a relatively high risk of VTE development.
We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM.
During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60.
T1DM appears to be an independent risk factor for VTE development.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0226997</identifier><identifier>PMID: 31935226</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Biology and Life Sciences ; Cohort analysis ; Cohort Studies ; Comorbidity ; Confidence intervals ; Critical care ; Databases, Factual ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - epidemiology ; Dyslipidemia ; Endocrinology ; Fractures ; Health ; Health hazards ; Heart failure ; Hospitals ; Humans ; Hyperlipidemia ; Hypertension ; Insurance ; Internal medicine ; Medical research ; Medicine ; Medicine and Health Sciences ; Metabolism ; Middle Aged ; Mortality ; National health insurance ; Obesity ; Online databases ; Patients ; People and Places ; Population ; Population studies ; Population-based studies ; Proportional Hazards Models ; Public health ; Regression analysis ; Respiratory therapy ; Retrospective Studies ; Risk analysis ; Risk Assessment ; Risk Factors ; Stroke ; Studies ; Surgery ; Taiwan - epidemiology ; Thromboembolism ; Type 1 diabetes ; Type 2 diabetes ; Venous Thromboembolism - epidemiology ; Venous Thromboembolism - etiology ; Young Adult</subject><ispartof>PloS one, 2020-01, Vol.15 (1), p.e0226997-e0226997</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Peng et al 2020 Peng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-bcc73ac8bf77aac96746d7d0673062a3831ba35658ea0acdcb0aee7234c0514b3</citedby><cites>FETCH-LOGICAL-c692t-bcc73ac8bf77aac96746d7d0673062a3831ba35658ea0acdcb0aee7234c0514b3</cites><orcidid>0000-0002-6095-3335 ; 0000-0001-9104-4487</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959573/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959573/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31935226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Yi-Hao</creatorcontrib><creatorcontrib>Lin, Yu-Sheng</creatorcontrib><creatorcontrib>Chen, Chia-Hung</creatorcontrib><creatorcontrib>Tsai, Kun-Yuan</creatorcontrib><creatorcontrib>Hung, Yi-Chih</creatorcontrib><creatorcontrib>Chen, Hsuan-Ju</creatorcontrib><creatorcontrib>Liao, Wei-Chih</creatorcontrib><creatorcontrib>Ho, Wen-Chao</creatorcontrib><title>Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored.
We investigated whether patients with T1DM are at a relatively high risk of VTE development.
We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM.
During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60.
T1DM appears to be an independent risk factor for VTE development.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Critical care</subject><subject>Databases, Factual</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Dyslipidemia</subject><subject>Endocrinology</subject><subject>Fractures</subject><subject>Health</subject><subject>Health hazards</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Insurance</subject><subject>Internal medicine</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>National health insurance</subject><subject>Obesity</subject><subject>Online databases</subject><subject>Patients</subject><subject>People and Places</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Proportional Hazards Models</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Respiratory therapy</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Studies</subject><subject>Surgery</subject><subject>Taiwan - epidemiology</subject><subject>Thromboembolism</subject><subject>Type 1 diabetes</subject><subject>Type 2 diabetes</subject><subject>Venous Thromboembolism - epidemiology</subject><subject>Venous Thromboembolism - etiology</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9GAIHqxazKZJBMvhFL8KBQKWr0NZzJndlNnJ9MkU90L_7vZdlu60gsJIcPJ876ZnJxTFM8ZnTOu2LtzP4UB-vnoB5zTspRaqwfFPtO8nMmS8od3vveKJzGeUyp4LeXjYo_nHZEl-8Wfs_WIhJHWQYMJI3GRQIzeOkjYkl8uLQkMxA02IMQcCS7-JL4jlzj4KZK0DH7VeMyzd3H1nhySgCn4OKJN7hLJ6Meph-T8MGuuDKxf-pBITFO7flo86qCP-Gy7HhTfP308O_oyOzn9fHx0eDKzUpdp1lirONi66ZQCsFqqSraqpVJxKkvgNWcNcCFFjUDBtrahgKhKXlkqWNXwg-Llte_Y-2i2mYum5FxpTetMHhTH10Tr4dyMwa0grI0HZ64CPiwMhORsjwZry-pOqNrasuKy0VYLRoXAUghaUZW9PmxPm5oVthaHFKDfMd3dGdzSLPylkVpooXg2eLM1CP5iwpjMykWLfQ8D5qRv_ltTWlUly-irf9D7b7elFpAv4IbO53PtxtQcSsY4VUzLTM3vofJoceVsLrPO5fiO4O2OIDMJf6cFTDGa429f_589_bHLvr7DLhH6tIy-nzZVFHfB6hq0ueJiwO42yYyaTZfcZMNsusRsuyTLXtx9oFvRTVvwv8HsDgM</recordid><startdate>20200114</startdate><enddate>20200114</enddate><creator>Peng, Yi-Hao</creator><creator>Lin, Yu-Sheng</creator><creator>Chen, Chia-Hung</creator><creator>Tsai, Kun-Yuan</creator><creator>Hung, Yi-Chih</creator><creator>Chen, Hsuan-Ju</creator><creator>Liao, Wei-Chih</creator><creator>Ho, Wen-Chao</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6095-3335</orcidid><orcidid>https://orcid.org/0000-0001-9104-4487</orcidid></search><sort><creationdate>20200114</creationdate><title>Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study</title><author>Peng, Yi-Hao ; Lin, Yu-Sheng ; Chen, Chia-Hung ; Tsai, Kun-Yuan ; Hung, Yi-Chih ; Chen, Hsuan-Ju ; Liao, Wei-Chih ; Ho, Wen-Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-bcc73ac8bf77aac96746d7d0673062a3831ba35658ea0acdcb0aee7234c0514b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Critical care</topic><topic>Databases, Factual</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes Mellitus, Type 1 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Yi-Hao</au><au>Lin, Yu-Sheng</au><au>Chen, Chia-Hung</au><au>Tsai, Kun-Yuan</au><au>Hung, Yi-Chih</au><au>Chen, Hsuan-Ju</au><au>Liao, Wei-Chih</au><au>Ho, Wen-Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-01-14</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>e0226997</spage><epage>e0226997</epage><pages>e0226997-e0226997</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored.
We investigated whether patients with T1DM are at a relatively high risk of VTE development.
We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM.
During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60.
T1DM appears to be an independent risk factor for VTE development.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31935226</pmid><doi>10.1371/journal.pone.0226997</doi><tpages>e0226997</tpages><orcidid>https://orcid.org/0000-0002-6095-3335</orcidid><orcidid>https://orcid.org/0000-0001-9104-4487</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-01, Vol.15 (1), p.e0226997-e0226997 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2337990872 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Age Aged Biology and Life Sciences Cohort analysis Cohort Studies Comorbidity Confidence intervals Critical care Databases, Factual Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - epidemiology Dyslipidemia Endocrinology Fractures Health Health hazards Heart failure Hospitals Humans Hyperlipidemia Hypertension Insurance Internal medicine Medical research Medicine Medicine and Health Sciences Metabolism Middle Aged Mortality National health insurance Obesity Online databases Patients People and Places Population Population studies Population-based studies Proportional Hazards Models Public health Regression analysis Respiratory therapy Retrospective Studies Risk analysis Risk Assessment Risk Factors Stroke Studies Surgery Taiwan - epidemiology Thromboembolism Type 1 diabetes Type 2 diabetes Venous Thromboembolism - epidemiology Venous Thromboembolism - etiology Young Adult |
| title | Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T05%3A39%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Type%201%20diabetes%20is%20associated%20with%20an%20increased%20risk%20of%20venous%20thromboembolism:%20A%20retrospective%20population-based%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Peng,%20Yi-Hao&rft.date=2020-01-14&rft.volume=15&rft.issue=1&rft.spage=e0226997&rft.epage=e0226997&rft.pages=e0226997-e0226997&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0226997&rft_dat=%3Cgale_plos_%3EA611307196%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2337990872&rft_id=info:pmid/31935226&rft_galeid=A611307196&rft_doaj_id=oai_doaj_org_article_e8c18f578cc2436b9c951055e2550407&rfr_iscdi=true |