Optimization of cytotoxic activity of Nocardia sp culture broths using a design of experiments

In the context of research for new cytotoxic compounds, obtaining bioactive molecules from renewable sources remain a big challenge. Microorganisms and more specifically Actinobacteria from original sources are well known for their biotechnological potential and are hotspots for the discovery of new...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0227816-e0227816
Hauptverfasser:	Noël, Alba, Van Soen, Gwendoline, Rouaud, Isabelle, Hitti, Eric, Tomasi, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Bacterial cultures Bioactive compounds Biocompatibility Biological activity Biology and Life Sciences Bioreactors Biotechnology Blood vessels Broths Cancer Cell culture Cell Line Cell lines Cell Survival - drug effects Chemical properties Chemical Sciences Culture Media - chemistry Culture Media - metabolism Culture Media - toxicity Cytotoxicity Cytotoxins - isolation & purification Cytotoxins - metabolism Cytotoxins - toxicity Design of experiments Flasks Health aspects Humans Industrial Microbiology Inoculum Keratinocytes - cytology Keratinocytes - drug effects Life Sciences Medicinal Chemistry Medicine and Health Sciences Melanoma Metabolites Mice Microbial biotechnology Microbiological research Microorganisms Nocardia Nocardia - chemistry Nocardia - metabolism Nocardia Infections - microbiology Optimization Orthogonal arrays Parameters pH effects Phylogenetics Physical Sciences Research and Analysis Methods Statistical methods Temperature Toxicity Tumor cell lines Variance analysis
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