Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation
KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We invest...
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| creator | Berastegui, Cristina Gómez-Ollés, Susana Mendoza-Valderrey, Alberto Pereira-Veiga, Thais Culebras, Mario Monforte, Victor Saez, Berta López-Meseguer, Manuel Sintes-Permanyer, Helena Ruiz de Miguel, Victoria Bravo, Carlos Sacanell, Judit Ramon, María-Antonia Romero, Laura Deu, María Román, Antonio |
| description | KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients. |
| doi_str_mv | 10.1371/journal.pone.0226488 |
| format | Article |
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Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0226488</identifier><identifier>PMID: 31929536</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Alveoli ; Antigens ; Area Under Curve ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Bronchiolitis obliterans ; Bronchiolitis Obliterans - diagnosis ; Bronchiolitis Obliterans - etiology ; Bronchoalveolar Lavage Fluid - chemistry ; Bronchopneumonia ; Bronchus ; Clinical trials ; Female ; Genotype & phenotype ; Humans ; Levels ; Lung diseases ; Lung Diseases - therapy ; Lung transplantation ; Lung Transplantation - adverse effects ; Male ; Medicine and Health Sciences ; Middle Aged ; Mucin-1 - analysis ; Mucin-1 - blood ; Phenotype ; Phenotypes ; Physical Sciences ; Physiology ; Pneumocytes ; Population ; Primary Graft Dysfunction - diagnosis ; Primary Graft Dysfunction - etiology ; Research and Analysis Methods ; ROC Curve ; Sensitivity and Specificity ; Studies ; Transplantation ; Transplantation, Homologous ; Vital Capacity ; Wound healing ; Xenografts ; Young Adult</subject><ispartof>PloS one, 2020-01, Vol.15 (1), p.e0226488-e0226488</ispartof><rights>2020 Berastegui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Berastegui et al 2020 Berastegui et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-6286e25db134cba2af5ca2fb2ba376470f0b5a9ecf565c6b87fef8a498b24d133</citedby><cites>FETCH-LOGICAL-c526t-6286e25db134cba2af5ca2fb2ba376470f0b5a9ecf565c6b87fef8a498b24d133</cites><orcidid>0000-0002-8935-7641 ; 0000-0003-4849-1593</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957146/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957146/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31929536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tchantchaleishvili, Vakhtang</contributor><creatorcontrib>Berastegui, Cristina</creatorcontrib><creatorcontrib>Gómez-Ollés, Susana</creatorcontrib><creatorcontrib>Mendoza-Valderrey, Alberto</creatorcontrib><creatorcontrib>Pereira-Veiga, Thais</creatorcontrib><creatorcontrib>Culebras, Mario</creatorcontrib><creatorcontrib>Monforte, Victor</creatorcontrib><creatorcontrib>Saez, Berta</creatorcontrib><creatorcontrib>López-Meseguer, Manuel</creatorcontrib><creatorcontrib>Sintes-Permanyer, Helena</creatorcontrib><creatorcontrib>Ruiz de Miguel, Victoria</creatorcontrib><creatorcontrib>Bravo, Carlos</creatorcontrib><creatorcontrib>Sacanell, Judit</creatorcontrib><creatorcontrib>Ramon, María-Antonia</creatorcontrib><creatorcontrib>Romero, Laura</creatorcontrib><creatorcontrib>Deu, María</creatorcontrib><creatorcontrib>Román, Antonio</creatorcontrib><title>Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.</description><subject>Adult</subject><subject>Aged</subject><subject>Alveoli</subject><subject>Antigens</subject><subject>Area Under Curve</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bronchiolitis obliterans</subject><subject>Bronchiolitis Obliterans - diagnosis</subject><subject>Bronchiolitis Obliterans - etiology</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchopneumonia</subject><subject>Bronchus</subject><subject>Clinical trials</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Levels</subject><subject>Lung diseases</subject><subject>Lung Diseases - therapy</subject><subject>Lung transplantation</subject><subject>Lung Transplantation - adverse effects</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mucin-1 - analysis</subject><subject>Mucin-1 - blood</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Pneumocytes</subject><subject>Population</subject><subject>Primary Graft Dysfunction - diagnosis</subject><subject>Primary Graft Dysfunction - etiology</subject><subject>Research and Analysis Methods</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><subject>Transplantation</subject><subject>Transplantation, Homologous</subject><subject>Vital Capacity</subject><subject>Wound healing</subject><subject>Xenografts</subject><subject>Young 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Manuel</au><au>Sintes-Permanyer, Helena</au><au>Ruiz de Miguel, Victoria</au><au>Bravo, Carlos</au><au>Sacanell, Judit</au><au>Ramon, María-Antonia</au><au>Romero, Laura</au><au>Deu, María</au><au>Román, Antonio</au><au>Tchantchaleishvili, Vakhtang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>e0226488</spage><epage>e0226488</epage><pages>e0226488-e0226488</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31929536</pmid><doi>10.1371/journal.pone.0226488</doi><orcidid>https://orcid.org/0000-0002-8935-7641</orcidid><orcidid>https://orcid.org/0000-0003-4849-1593</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-01, Vol.15 (1), p.e0226488-e0226488 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2337055414 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Alveoli Antigens Area Under Curve Biology and Life Sciences Biomarkers Biomarkers - blood Bronchiolitis obliterans Bronchiolitis Obliterans - diagnosis Bronchiolitis Obliterans - etiology Bronchoalveolar Lavage Fluid - chemistry Bronchopneumonia Bronchus Clinical trials Female Genotype & phenotype Humans Levels Lung diseases Lung Diseases - therapy Lung transplantation Lung Transplantation - adverse effects Male Medicine and Health Sciences Middle Aged Mucin-1 - analysis Mucin-1 - blood Phenotype Phenotypes Physical Sciences Physiology Pneumocytes Population Primary Graft Dysfunction - diagnosis Primary Graft Dysfunction - etiology Research and Analysis Methods ROC Curve Sensitivity and Specificity Studies Transplantation Transplantation, Homologous Vital Capacity Wound healing Xenografts Young Adult |
| title | Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T02%3A20%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20serum%20KL-6%20level%20for%20detecting%20patients%20with%20restrictive%20allograft%20syndrome%20after%20lung%20transplantation&rft.jtitle=PloS%20one&rft.au=Berastegui,%20Cristina&rft.date=2020-01-01&rft.volume=15&rft.issue=1&rft.spage=e0226488&rft.epage=e0226488&rft.pages=e0226488-e0226488&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0226488&rft_dat=%3Cproquest_plos_%3E2337055414%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2337055414&rft_id=info:pmid/31929536&rft_doaj_id=oai_doaj_org_article_a4c6ffe37e664cf7a70ce747cac3c9d8&rfr_iscdi=true |