A preliminary study of resting brain metabolism in treatment-resistant depression before and after treatment with olanzapine-fluoxetine combination

Treatment-resistant depression (TRD) occurs in many patients and causes high morbidity and mortality. Because TRD subjects are particularly difficult to study especially longitudinally, biological data remain very limited. In a preliminary study to judge feasibility and power, 25 TRD patients were r...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0226486
Hauptverfasser:	Pardo, José V, Sheikh, Sohail A, Schwindt, Graeme, Lee, Joel T, Adson, David E, Rittberg, Barry, Abuzzahab, Sr, Faruk S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amygdala Amygdala - diagnostic imaging Amygdala - metabolism Antidepressants Antipsychotics Anxiety Benzodiazepines - therapeutic use Biology and Life Sciences Biomarkers Brain - diagnostic imaging Brain - metabolism Brain research Brodmann's area Correlation analysis Cortex (cingulate) Depressive Disorder, Treatment-Resistant - drug therapy Depressive Disorder, Treatment-Resistant - metabolism Depressive Disorder, Treatment-Resistant - pathology Diagnostic systems Drug Combinations Drug dosages Feasibility studies Female Fluoxetine Fluoxetine - therapeutic use Gene expression Heterogeneity Humans Hyperactivity Image Processing, Computer-Assisted Insomnia Magnetic resonance Magnetic resonance imaging Male Medical imaging Medicine and Health Sciences Mental depression Mental disorders Mental health Metabolism Middle Aged Morbidity Neurogenesis Neuroimaging Olanzapine Patients Positron emission Positron emission tomography Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - metabolism Psychiatry Severity of Illness Index Sleep disorders Studies Transcranial magnetic stimulation
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