Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease

Alzheimer's disease (AD) is an ageing-related neurodegenerative disease characterized and diagnosed by deposition of insoluble amyloid-β (Aβ) plaques in the brain. The plaque accumulation in the brain directly affects reduced levels of Aβ in cerebrospinal fluid (CSF) and blood, as Aβ can freely...

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Veröffentlicht in:	PloS one 2020-01, Vol.15 (1), p.e0227618-e0227618
Hauptverfasser:	Kwak, Da Eun, Ko, Taeho, Koh, Han Seok, Ji, Yong Woo, Shin, Jisu, Kim, Kyeonghwan, Kim, Hye Yun, Lee, Hyung-Keun, Kim, YoungSoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aging Alzheimer Disease - physiopathology Alzheimer's disease Amyloid Amyloid beta-Peptides - analysis Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - physiology Amyloid beta-Protein Precursor - metabolism Animal models Animals Aqueous Humor - cytology Aqueous Humor - metabolism Aqueous humour Biology and Life Sciences Biomarkers Biomarkers - blood Blood-brain barrier Blood-Brain Barrier - metabolism Brain - metabolism Brain research Cerebrospinal fluid Deposition Disease Models, Animal Female Humans Laboratory animals Low density lipoprotein receptors Male Medical research Medicine and Health Sciences Mice Mice, Inbred ICR Mice, Transgenic Nervous system Neurodegenerative diseases Peptides Pharmaceutical sciences Pharmacy Plaque, Amyloid Proteins Research and Analysis Methods Senile plaques Transgenic mice Veins & arteries
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