Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH)

Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease characterized by dysregulated lipid metabolism and chronic inflammation ultimately resulting in fibrosis. Untreated, NAFLD may progress to non-alcoholic steatohepatitis (NASH), cirrhosis and death. However, currently there are...

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Veröffentlicht in:	PloS one 2019-12, Vol.14 (12), p.e0226854-e0226854
Hauptverfasser:	Min-DeBartolo, Jessica, Schlerman, Franklin, Akare, Sandeep, Wang, Ju, McMahon, James, Zhan, Yutian, Syed, Jameel, He, Wen, Zhang, Baohong, Martinez, Robert V
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Activation Alcohol Amino acids Angiogenesis Animals Biology and Life Sciences Biomarkers - metabolism Bone morphogenetic proteins Cell activation Cell adhesion Cells, Cultured Choline Choline Deficiency Cirrhosis Collagen Collagen (type I) Death Diabetes Disease Models, Animal Drug approval Ecology and Environmental Sciences Environmental impact Enzymes Extracellular matrix Fatty liver Fibrosis Gene expression Genes Genotypes Glycoprotein Glycoproteins Growth factors Hepatic Stellate Cells High fat diet House mouse Humans Immunology Inflammation Insulin resistance International economic relations Lipid Metabolism Lipids Liver Liver - metabolism Liver - pathology Liver cirrhosis Liver diseases Male Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL Mice, Knockout Modulation Muscle proteins Muscles Non-alcoholic Fatty Liver Disease - chemically induced Non-alcoholic Fatty Liver Disease - metabolism Obesity Pathways Peptides Phenotypes Product safety R&D Research & development Research and Analysis Methods Ribonucleic acid RNA Safety research Scientific equipment industry Smooth muscle Steatosis Therapeutics Thrombospondin Thrombospondin 1 - genetics Thrombospondin 1 - physiology Transcriptomics Transforming growth factor-b1 Transforming growth factors Weight
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