Clinical impact of visceral-to-subcutaneous fat ratio in patients with acute aortic dissection
Obesity has increased worldwide. Although the visceral-to-subcutaneous fat ratio (VS ratio) is an established risk factor for cardiovascular disease, its clinical impact on the long-term prognosis of patients with acute aortic dissection (AAD) remains unclear. This retrospective study included 111 p...
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| description | Obesity has increased worldwide. Although the visceral-to-subcutaneous fat ratio (VS ratio) is an established risk factor for cardiovascular disease, its clinical impact on the long-term prognosis of patients with acute aortic dissection (AAD) remains unclear.
This retrospective study included 111 patients with AAD admitted to our hospital from 2013 to 2016. Patients who died during hospitalization, and those diagnosed with Marfan's syndrome were excluded. Visceral and subcutaneous fat accumulation (VFA, SFA) at umbilical level were calculated on a dedicated workstation. Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) and worsening renal function (WRF) at 3 years were evaluated.
Patient characteristics were as below: age, 73 ± 13; male, 55%; Stanford type A, 53%. Average VFA, SFA, and VS ratio on admission were 98 (52-145) cm2, 141 (90-185) cm2, and 0.75 (0.47-0.97), respectively. VFA was higher in male than in female (male, 134 [84-179] cm2; female, 71 [46-99] cm2; p < 0.001), whereas SFA was similar (male, 141 [91-174] cm2: female, 134 [90-205] cm2; p = 0.687). VS ratio was also higher in male (male, 0.88 [0.75-1.17]; female, 0.49 [0.39-0.65]; p < 0.001). Both MACCE and WRF at 3 years were observed in 17 (15%) and 32 (29%) patients, respectively. Multivariate Cox regression analysis demonstrated that VS ratio tended to be associated with the 3-year MACCE (HR for an increase of 0.5 unit, 1.49; 95% CI, 0.99-2.24; p = 0.056). This result persisted in male (HR for an increase of 0.5 unit, 1.54; 95% CI, 0.96-2.48; p = 0.073) but not female. The VS ratio was not related to the 3-year WRF.
The VS ratio tends to be associated with the 3-year MACCE in patients with AAD. This finding is inconclusive owing to a small sample and low incidence of adverse events. Further studies with larger samples are needed to confirm the clinical significance of VS ratio. |
| doi_str_mv | 10.1371/journal.pone.0226642 |
| format | Article |
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This retrospective study included 111 patients with AAD admitted to our hospital from 2013 to 2016. Patients who died during hospitalization, and those diagnosed with Marfan's syndrome were excluded. Visceral and subcutaneous fat accumulation (VFA, SFA) at umbilical level were calculated on a dedicated workstation. Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) and worsening renal function (WRF) at 3 years were evaluated.
Patient characteristics were as below: age, 73 ± 13; male, 55%; Stanford type A, 53%. Average VFA, SFA, and VS ratio on admission were 98 (52-145) cm2, 141 (90-185) cm2, and 0.75 (0.47-0.97), respectively. VFA was higher in male than in female (male, 134 [84-179] cm2; female, 71 [46-99] cm2; p < 0.001), whereas SFA was similar (male, 141 [91-174] cm2: female, 134 [90-205] cm2; p = 0.687). VS ratio was also higher in male (male, 0.88 [0.75-1.17]; female, 0.49 [0.39-0.65]; p < 0.001). Both MACCE and WRF at 3 years were observed in 17 (15%) and 32 (29%) patients, respectively. Multivariate Cox regression analysis demonstrated that VS ratio tended to be associated with the 3-year MACCE (HR for an increase of 0.5 unit, 1.49; 95% CI, 0.99-2.24; p = 0.056). This result persisted in male (HR for an increase of 0.5 unit, 1.54; 95% CI, 0.96-2.48; p = 0.073) but not female. The VS ratio was not related to the 3-year WRF.
The VS ratio tends to be associated with the 3-year MACCE in patients with AAD. This finding is inconclusive owing to a small sample and low incidence of adverse events. Further studies with larger samples are needed to confirm the clinical significance of VS ratio.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0226642</identifier><identifier>PMID: 31869368</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Aged ; Aged, 80 and over ; Aneurysm, Dissecting - diagnosis ; Aneurysm, Dissecting - pathology ; Angiotensin II ; Aorta ; Aortic dissection ; Biology and Life Sciences ; Blood pressure ; Body mass index ; Cardiology ; Cardiovascular diseases ; Care and treatment ; Cholesterol ; Diabetes ; Dissection ; Emergency medical care ; Environmental impact ; Ethics ; Female ; Gender differences ; Health aspects ; Health risks ; Heart attacks ; Humans ; Hypertension ; Intra-Abdominal Fat - pathology ; Male ; Medical imaging ; Medical prognosis ; Medical research ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Morphology ; Mortality ; Patients ; Physical Sciences ; Prognosis ; Proportional Hazards Models ; Regression analysis ; Renal function ; Research and Analysis Methods ; Retrospective Studies ; Risk analysis ; Risk factors ; Studies ; Subcutaneous Fat - pathology ; Surgery ; Workstations</subject><ispartof>PloS one, 2019-12, Vol.14 (12), p.e0226642-e0226642</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Miura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Miura et al 2019 Miura et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b8d71072c753e037a6d32c87c3fce6436993d2e9ec495655d9209eb4529683133</citedby><cites>FETCH-LOGICAL-c692t-b8d71072c753e037a6d32c87c3fce6436993d2e9ec495655d9209eb4529683133</cites><orcidid>0000-0002-7914-8256</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927613/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927613/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31869368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shimosawa, Tatsuo</contributor><creatorcontrib>Miura, Yusuke</creatorcontrib><creatorcontrib>Higuchi, Satoshi</creatorcontrib><creatorcontrib>Matsushita, Kenichi</creatorcontrib><creatorcontrib>Kariyasu, Toshiya</creatorcontrib><creatorcontrib>Machida, Haruhiko</creatorcontrib><creatorcontrib>Yokoyama, Kenichi</creatorcontrib><creatorcontrib>Soejima, Kyoko</creatorcontrib><creatorcontrib>Satoh, Toru</creatorcontrib><title>Clinical impact of visceral-to-subcutaneous fat ratio in patients with acute aortic dissection</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Obesity has increased worldwide. Although the visceral-to-subcutaneous fat ratio (VS ratio) is an established risk factor for cardiovascular disease, its clinical impact on the long-term prognosis of patients with acute aortic dissection (AAD) remains unclear.
This retrospective study included 111 patients with AAD admitted to our hospital from 2013 to 2016. Patients who died during hospitalization, and those diagnosed with Marfan's syndrome were excluded. Visceral and subcutaneous fat accumulation (VFA, SFA) at umbilical level were calculated on a dedicated workstation. Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) and worsening renal function (WRF) at 3 years were evaluated.
Patient characteristics were as below: age, 73 ± 13; male, 55%; Stanford type A, 53%. Average VFA, SFA, and VS ratio on admission were 98 (52-145) cm2, 141 (90-185) cm2, and 0.75 (0.47-0.97), respectively. VFA was higher in male than in female (male, 134 [84-179] cm2; female, 71 [46-99] cm2; p < 0.001), whereas SFA was similar (male, 141 [91-174] cm2: female, 134 [90-205] cm2; p = 0.687). VS ratio was also higher in male (male, 0.88 [0.75-1.17]; female, 0.49 [0.39-0.65]; p < 0.001). Both MACCE and WRF at 3 years were observed in 17 (15%) and 32 (29%) patients, respectively. Multivariate Cox regression analysis demonstrated that VS ratio tended to be associated with the 3-year MACCE (HR for an increase of 0.5 unit, 1.49; 95% CI, 0.99-2.24; p = 0.056). This result persisted in male (HR for an increase of 0.5 unit, 1.54; 95% CI, 0.96-2.48; p = 0.073) but not female. The VS ratio was not related to the 3-year WRF.
The VS ratio tends to be associated with the 3-year MACCE in patients with AAD. This finding is inconclusive owing to a small sample and low incidence of adverse events. Further studies with larger samples are needed to confirm the clinical significance of VS ratio.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneurysm, Dissecting - diagnosis</subject><subject>Aneurysm, Dissecting - pathology</subject><subject>Angiotensin II</subject><subject>Aorta</subject><subject>Aortic dissection</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Dissection</subject><subject>Emergency medical care</subject><subject>Environmental impact</subject><subject>Ethics</subject><subject>Female</subject><subject>Gender differences</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Mortality</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Subcutaneous Fat - pathology</subject><subject>Surgery</subject><subject>Workstations</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQDguhDx1zaXF6EZfAysLDg7dGQpslMhkwz26SrfnvTne4ylX2QPjSkv_M_5_x7TlE8R3CBCEPvtmHoO-UX-9CZBcSY0go_KE6RILikGJKHR-eT4kmMWwhrwil9XJwQxKkglJ8WP5fedU4rD9xur3QCwYJrF7XplS9TKOPQ6CGpzoQhAqsS6FVyAbgO7PPBdCmCXy5tgMqUASr0yWnQuhiNzlz3tHhklY_m2fQ-K75__PBt-bm8uPy0Wp5flJoKnMqGtwxBhjWriYGEKdoSrDnTxGpDK0KFIC02wuhK1LSuW4GhME1VY0E5QYScFS8PunsfopysiRITkptmjKJMrA5EG9RW7nu3U_0fGZSTNxehX0s1Fu-N5JaQhqGmEVRVkOPG1sK2BlrTGmGrMdv7KdvQ7Eyrsw3Zrpno_EvnNnIdrmVudqwlC7yZBPpwNZiY5G703PuD0Td1E4IYG9FX_6D3dzdRa5UbcJ0NOa8eReU5haLmHPI6U4t7qPy0Zud0niPr8v0s4O0sIDPJ_E5rNcQoV1-__D97-WPOvj5iN0b5tInBD-PIxDlYHUDdhxh7Y-9MRlCOa3DrhhzXQE5rkMNeHP-gu6DbuSd_AeD2Ano</recordid><startdate>20191223</startdate><enddate>20191223</enddate><creator>Miura, Yusuke</creator><creator>Higuchi, Satoshi</creator><creator>Matsushita, Kenichi</creator><creator>Kariyasu, Toshiya</creator><creator>Machida, Haruhiko</creator><creator>Yokoyama, Kenichi</creator><creator>Soejima, Kyoko</creator><creator>Satoh, Toru</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7914-8256</orcidid></search><sort><creationdate>20191223</creationdate><title>Clinical impact of visceral-to-subcutaneous fat ratio in patients with acute aortic dissection</title><author>Miura, Yusuke ; Higuchi, Satoshi ; Matsushita, Kenichi ; Kariyasu, Toshiya ; Machida, Haruhiko ; Yokoyama, Kenichi ; Soejima, Kyoko ; Satoh, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b8d71072c753e037a6d32c87c3fce6436993d2e9ec495655d9209eb4529683133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneurysm, Dissecting - diagnosis</topic><topic>Aneurysm, Dissecting - pathology</topic><topic>Angiotensin II</topic><topic>Aorta</topic><topic>Aortic dissection</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Dissection</topic><topic>Emergency medical care</topic><topic>Environmental impact</topic><topic>Ethics</topic><topic>Female</topic><topic>Gender differences</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Mortality</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>Research and Analysis Methods</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Subcutaneous Fat - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miura, Yusuke</au><au>Higuchi, Satoshi</au><au>Matsushita, Kenichi</au><au>Kariyasu, Toshiya</au><au>Machida, Haruhiko</au><au>Yokoyama, Kenichi</au><au>Soejima, Kyoko</au><au>Satoh, Toru</au><au>Shimosawa, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical impact of visceral-to-subcutaneous fat ratio in patients with acute aortic dissection</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-12-23</date><risdate>2019</risdate><volume>14</volume><issue>12</issue><spage>e0226642</spage><epage>e0226642</epage><pages>e0226642-e0226642</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Obesity has increased worldwide. Although the visceral-to-subcutaneous fat ratio (VS ratio) is an established risk factor for cardiovascular disease, its clinical impact on the long-term prognosis of patients with acute aortic dissection (AAD) remains unclear.
This retrospective study included 111 patients with AAD admitted to our hospital from 2013 to 2016. Patients who died during hospitalization, and those diagnosed with Marfan's syndrome were excluded. Visceral and subcutaneous fat accumulation (VFA, SFA) at umbilical level were calculated on a dedicated workstation. Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) and worsening renal function (WRF) at 3 years were evaluated.
Patient characteristics were as below: age, 73 ± 13; male, 55%; Stanford type A, 53%. Average VFA, SFA, and VS ratio on admission were 98 (52-145) cm2, 141 (90-185) cm2, and 0.75 (0.47-0.97), respectively. VFA was higher in male than in female (male, 134 [84-179] cm2; female, 71 [46-99] cm2; p < 0.001), whereas SFA was similar (male, 141 [91-174] cm2: female, 134 [90-205] cm2; p = 0.687). VS ratio was also higher in male (male, 0.88 [0.75-1.17]; female, 0.49 [0.39-0.65]; p < 0.001). Both MACCE and WRF at 3 years were observed in 17 (15%) and 32 (29%) patients, respectively. Multivariate Cox regression analysis demonstrated that VS ratio tended to be associated with the 3-year MACCE (HR for an increase of 0.5 unit, 1.49; 95% CI, 0.99-2.24; p = 0.056). This result persisted in male (HR for an increase of 0.5 unit, 1.54; 95% CI, 0.96-2.48; p = 0.073) but not female. The VS ratio was not related to the 3-year WRF.
The VS ratio tends to be associated with the 3-year MACCE in patients with AAD. This finding is inconclusive owing to a small sample and low incidence of adverse events. Further studies with larger samples are needed to confirm the clinical significance of VS ratio.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31869368</pmid><doi>10.1371/journal.pone.0226642</doi><tpages>e0226642</tpages><orcidid>https://orcid.org/0000-0002-7914-8256</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-12, Vol.14 (12), p.e0226642-e0226642 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2330057761 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Aged Aged, 80 and over Aneurysm, Dissecting - diagnosis Aneurysm, Dissecting - pathology Angiotensin II Aorta Aortic dissection Biology and Life Sciences Blood pressure Body mass index Cardiology Cardiovascular diseases Care and treatment Cholesterol Diabetes Dissection Emergency medical care Environmental impact Ethics Female Gender differences Health aspects Health risks Heart attacks Humans Hypertension Intra-Abdominal Fat - pathology Male Medical imaging Medical prognosis Medical research Medicine Medicine and Health Sciences Middle Aged Morphology Mortality Patients Physical Sciences Prognosis Proportional Hazards Models Regression analysis Renal function Research and Analysis Methods Retrospective Studies Risk analysis Risk factors Studies Subcutaneous Fat - pathology Surgery Workstations |
| title | Clinical impact of visceral-to-subcutaneous fat ratio in patients with acute aortic dissection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T10%3A51%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20impact%20of%20visceral-to-subcutaneous%20fat%20ratio%20in%20patients%20with%20acute%20aortic%20dissection&rft.jtitle=PloS%20one&rft.au=Miura,%20Yusuke&rft.date=2019-12-23&rft.volume=14&rft.issue=12&rft.spage=e0226642&rft.epage=e0226642&rft.pages=e0226642-e0226642&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0226642&rft_dat=%3Cgale_plos_%3EA609588085%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2330057761&rft_id=info:pmid/31869368&rft_galeid=A609588085&rft_doaj_id=oai_doaj_org_article_8f33b71bb96a4082bf59fde0fede9f43&rfr_iscdi=true |