Cost effectiveness of therapeutic drug monitoring for imatinib administration in chronic myeloid leukemia

Imatinib mesylate (IM) is a first-line treatment option for patients with chronic myeloid leukemia (CML). Patients who fail or are intolerant to IM therapy are treated with more expensive second and third-generation tyrosine kinase inhibitors. Patients show wide variation in trough concentrations in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2019-12, Vol.14 (12), p.e0226552-e0226552
Hauptverfasser:	Kim, Kibum, McMillin, Gwendolyn A, Bernard, Philip S, Tantravahi, Srinivas, Walker, Brandon S, Schmidt, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - economics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biology and Life Sciences Bosutinib Chemotherapy Chronic myeloid leukemia Computer Simulation Cost analysis Cost effectiveness Cost-Benefit Analysis Cytogenetic Analysis Cytogenetics Dasatinib Dosage Drug dosages Drug Monitoring - economics Drug Monitoring - methods Drug Resistance, Neoplasm - genetics Drug-Related Side Effects and Adverse Reactions - economics Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - genetics Drug-Related Side Effects and Adverse Reactions - therapy Drugs, Generic - economics Drugs, Generic - therapeutic use Economic aspects Generic drugs Health aspects Hematopoietic Stem Cell Transplantation - economics Hematopoietic Stem Cell Transplantation - statistics & numerical data Humans Imatinib Imatinib Mesylate - economics Imatinib Mesylate - therapeutic use Inhibitor drugs Kinases Laboratories Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - economics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - epidemiology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Medication Adherence - statistics & numerical data Medicine and Health Sciences Monitoring Mutation Myeloid leukemia Nilotinib Pathology Patients Pharmacogenomic Testing Phenols (Class of compounds) Ponatinib Protein-tyrosine kinase Quality-Adjusted Life Years Sensitivity analysis Social Sciences Stem cell transplantation Success Survival Analysis Targeted cancer therapy Therapeutic drug monitoring Therapy Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!