CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline

To maintain the integrity of the genome, meiotic DNA double strand breaks (DSBs) need to form by the meiosis-specific nuclease Spo11 and be repaired by homologous recombination. One class of products formed by recombination are crossovers, which are required for proper chromosome segregation in the...

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Veröffentlicht in:	PLoS genetics 2019-11, Vol.15 (11), p.e1008486-e1008486
Hauptverfasser:	Alleva, Benjamin, Clausen, Sean, Koury, Emily, Hefel, Adam, Smolikove, Sarit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Backup software Biology Biology and life sciences Biotechnology Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins - genetics Chromosome Pairing - genetics Chromosome Segregation - genetics Chromosomes Crossing Over, Genetic Cullin Deoxyribonucleic acid Deregulation DNA DNA Breaks, Double-Stranded DNA damage Endodeoxyribonucleases - genetics Enzymes Genomes Genomics Germ Cells - growth & development Homologous recombination Homologous Recombination - genetics Ligases Ligases - genetics Meiosis Meiosis - genetics Meiotic Prophase I - genetics Nematodes Nuclease Prophase Protein structure Proteins Research and Analysis Methods Synaptonemal complex Synaptonemal Complex - genetics Transposition Transposons Ubiquitin Ubiquitin-protein ligase Ubiquitination Yeast
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