The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. While this drug is safe, its inability to kill all schistosome lifecycle stages within the human host often requires...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-11, Vol.13 (11), p.e0007693
Hauptverfasser:	Whatley, Kezia C L, Padalino, Gilda, Whiteland, Helen, Geyer, Kathrin K, Hulme, Benjamin J, Chalmers, Iain W, Forde-Thomas, Josephine, Ferla, Salvatore, Brancale, Andrea, Hoffmann, Karl F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintic agents Anthelmintics - pharmacology Antiparasitic agents Auranofin Bays Benzazepines - pharmacology Biology and Life Sciences Cancer treatment Chemotherapy Combinatorial analysis Computational Biology - methods Consortia Defects Demethylation DNA probes Dose-Response Relationship, Drug Drug delivery Drug development Drug Repositioning - methods Egg production Eggs Epigenesis, Genetic Epigenetic inheritance Epigenetics Female Gene expression Genomes Genomics Health aspects Hep G2 Cells Histone methyltransferase Histones Histones - genetics Humans Incubation Incubation period Inhibitors Jumonji Domain-Containing Histone Demethylases Lead - pharmacology Lead compounds Life cycle analysis Male Methylation Methyltransferases Models, Molecular Modulators Molecular Docking Simulation Motility Novels Nucleic acids Oviposition Oviposition - drug effects Packaging Pharmaceutical sciences Pharmacy Phenotypes Physical Sciences Praziquantel Probes Proteins Pyrimidines - pharmacology R&D Research & development Research and Analysis Methods RNA RNA interference RNA-mediated interference Schistosoma mansoni Schistosoma mansoni - drug effects Schistosoma mansoni - genetics Schistosomatidae - drug effects Schistosomatidae - genetics Schistosomiasis Schistosomiasis - drug therapy Schistosomiasis mansoni - drug therapy Schistosomiasis mansoni - parasitology Sensors Therapeutics Titration Transferases Tropical climate Tropical diseases
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