CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans

The onset of sexual maturity involves dramatic changes in physiology and gene expression in many animals. These include abundant yolk protein production in egg-laying species, an energetically costly process under extensive transcriptional control. Here, we used the model organism Caenorhabditis ele...

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Veröffentlicht in:	PLoS biology 2019-11, Vol.17 (11), p.e3000499-e3000499
Hauptverfasser:	Van de Walle, Pieter, Geens, Ellen, Baggerman, Geert, José Naranjo-Galindo, Francisco, Askjaer, Peter, Schoofs, Liliane, Temmerman, Liesbet
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Caenorhabditis elegans Proteins - physiology Collagen - metabolism Complementation Cuticles Dehydrogenases DNA binding proteins Egg laying Electron micrographs Epicuticle Fluorescence Funding Gene expression Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeodomain Proteins - physiology Homeostasis Hypodermis Intestinal Mucosa - metabolism Intestine Intestines Kinases Leukemia Lipid Metabolism Lipids Medicine and Health Sciences Metabolism Neurobiology Neurons Neurosciences Oxidative Stress Permeability Physical Sciences Physiological aspects Physiology Proteins Proteomics Research and Analysis Methods Scientific equipment and supplies industry Sexual maturity Transcription Factors Transcription Factors, General - genetics Transcription Factors, General - metabolism Transcription Factors, General - physiology Vitellogenesis Vitellogenesis - genetics Yolk Yolk protein
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