The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study
Spinal anesthesia is a form of regional anesthesia frequently used in various lower abdominal, orthopedic, obstetric operations such as a cesarean delivery. The most common local anesthetic used for spinal anesthesia in obstetric and non-obstetric surgery is bupivacaine which can be utilized as an i...
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| creator | Helill, Shamill Eanga Sahile, Wossenyeleh Admasu Abdo, Ritbano Ahmed Wolde, Getahun Dendir Halil, Hassen Mosa |
| description | Spinal anesthesia is a form of regional anesthesia frequently used in various lower abdominal, orthopedic, obstetric operations such as a cesarean delivery. The most common local anesthetic used for spinal anesthesia in obstetric and non-obstetric surgery is bupivacaine which can be utilized as an isobaric or hyperbaric solution, producing differences in maternal hemodynamic changes. Against this backdrop, the study aims to compare the effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic alterations after administering spinal anesthesia for elective cesarean delivery at Gandhi Memorial Hospital, Addis Ababa, Ethiopia.
A hospital-based prospective cohort study design was employed for the period December 1, 2017 to January 30, 2018. A total of 100 parturient were involved, with one group exposed to isobaric bupivacaine and the other to hyperbaric bupivacaine to observe their effects on maternal hemodynamic changes post spinal anesthesia. The participants were selected through systematic random sampling. Data analysis was performed using SPSS (version 20) through descriptive statistic, independent sample t-test, Mann-Whitney U-test, Fisher's exact test, and Chi-square test were used. P values of |
| doi_str_mv | 10.1371/journal.pone.0226030 |
| format | Article |
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A hospital-based prospective cohort study design was employed for the period December 1, 2017 to January 30, 2018. A total of 100 parturient were involved, with one group exposed to isobaric bupivacaine and the other to hyperbaric bupivacaine to observe their effects on maternal hemodynamic changes post spinal anesthesia. The participants were selected through systematic random sampling. Data analysis was performed using SPSS (version 20) through descriptive statistic, independent sample t-test, Mann-Whitney U-test, Fisher's exact test, and Chi-square test were used. P values of <0.05 was assumed as statistically significant for all tests.
The incidence of hypotension was found to be greater in isobaric than hyperbaric groups (82% vs. 60% respectively; p = 0.015). No statistical significant differences were found in mean arterial pressure value at baseline, but, statistically significant changes were observed among the groups (p <0.05) at all study timing after spinal anesthesia, except at 30thmin. No statistically significant differences were seen in the mean heart rate variability after spinal anesthesia at all periods, except the 15th minute (p = 0.033). A greater rate of vasopressor was used in the isobaric group as compared to the hyperbaric group (36% vs. 14% respectively; p = 0.011).
Baricity is a significant factor in maternal hemodynamic changes in the parturient for elective cesarean section. Isobaric bupivacaine produces greater change in blood pressure and incidence of hypotension and entails a greater vasopressor requirement than hyperbaric bupivacaine after spinal anesthesia for elective cesarean section.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0226030</identifier><identifier>PMID: 31830074</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adult ; Analysis ; Anesthesia ; Anesthesia, Obstetrical ; Anesthesia, Spinal - adverse effects ; Anesthesiology ; Blood pressure ; Blood Pressure - drug effects ; Bupivacaine ; Bupivacaine - administration & dosage ; Bupivacaine - adverse effects ; Cesarean section ; Cesarean Section - adverse effects ; Cesarean Section - methods ; Chi-square test ; Cohort analysis ; Cohort Studies ; Computer and Information Sciences ; Data analysis ; Data collection ; Elective Surgical Procedures - adverse effects ; Ethiopia ; Female ; Health risk assessment ; Health sciences ; Heart rate ; Hemodynamics ; Hemodynamics - drug effects ; Hospitals ; Humans ; Hypotension ; Hypotension - chemically induced ; Hypotension - physiopathology ; Incidence ; Information management ; Injections, Spinal - adverse effects ; Medicine ; Medicine and Health Sciences ; Midwifery ; Mothers ; Obstetrics ; Orthopedics ; Pregnancy ; Prospective Studies ; Random sampling ; Statistical analysis ; Statistical sampling ; Statistical significance ; Statistical tests ; Surgery ; Treatment Outcome ; Young Adult</subject><ispartof>PloS one, 2019-12, Vol.14 (12), p.e0226030-e0226030</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Helill et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Helill et al 2019 Helill et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-21dccdcfe1ddf2b6c8e00bfb1927ef32bed43f2ba1bbbcc553788d5f39f0282a3</citedby><cites>FETCH-LOGICAL-c692t-21dccdcfe1ddf2b6c8e00bfb1927ef32bed43f2ba1bbbcc553788d5f39f0282a3</cites><orcidid>0000-0003-2867-7526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907792/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907792/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31830074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Farag, Ehab</contributor><creatorcontrib>Helill, Shamill Eanga</creatorcontrib><creatorcontrib>Sahile, Wossenyeleh Admasu</creatorcontrib><creatorcontrib>Abdo, Ritbano Ahmed</creatorcontrib><creatorcontrib>Wolde, Getahun Dendir</creatorcontrib><creatorcontrib>Halil, Hassen Mosa</creatorcontrib><title>The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Spinal anesthesia is a form of regional anesthesia frequently used in various lower abdominal, orthopedic, obstetric operations such as a cesarean delivery. The most common local anesthetic used for spinal anesthesia in obstetric and non-obstetric surgery is bupivacaine which can be utilized as an isobaric or hyperbaric solution, producing differences in maternal hemodynamic changes. Against this backdrop, the study aims to compare the effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic alterations after administering spinal anesthesia for elective cesarean delivery at Gandhi Memorial Hospital, Addis Ababa, Ethiopia.
A hospital-based prospective cohort study design was employed for the period December 1, 2017 to January 30, 2018. A total of 100 parturient were involved, with one group exposed to isobaric bupivacaine and the other to hyperbaric bupivacaine to observe their effects on maternal hemodynamic changes post spinal anesthesia. The participants were selected through systematic random sampling. Data analysis was performed using SPSS (version 20) through descriptive statistic, independent sample t-test, Mann-Whitney U-test, Fisher's exact test, and Chi-square test were used. P values of <0.05 was assumed as statistically significant for all tests.
The incidence of hypotension was found to be greater in isobaric than hyperbaric groups (82% vs. 60% respectively; p = 0.015). No statistical significant differences were found in mean arterial pressure value at baseline, but, statistically significant changes were observed among the groups (p <0.05) at all study timing after spinal anesthesia, except at 30thmin. No statistically significant differences were seen in the mean heart rate variability after spinal anesthesia at all periods, except the 15th minute (p = 0.033). A greater rate of vasopressor was used in the isobaric group as compared to the hyperbaric group (36% vs. 14% respectively; p = 0.011).
Baricity is a significant factor in maternal hemodynamic changes in the parturient for elective cesarean section. Isobaric bupivacaine produces greater change in blood pressure and incidence of hypotension and entails a greater vasopressor requirement than hyperbaric bupivacaine after spinal anesthesia for elective cesarean section.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Analysis</subject><subject>Anesthesia</subject><subject>Anesthesia, Obstetrical</subject><subject>Anesthesia, Spinal - adverse effects</subject><subject>Anesthesiology</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Bupivacaine</subject><subject>Bupivacaine - administration & dosage</subject><subject>Bupivacaine - adverse effects</subject><subject>Cesarean section</subject><subject>Cesarean Section - adverse effects</subject><subject>Cesarean Section - methods</subject><subject>Chi-square test</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Computer and Information Sciences</subject><subject>Data analysis</subject><subject>Data collection</subject><subject>Elective Surgical Procedures - adverse effects</subject><subject>Ethiopia</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Health sciences</subject><subject>Heart rate</subject><subject>Hemodynamics</subject><subject>Hemodynamics - drug effects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypotension</subject><subject>Hypotension - chemically induced</subject><subject>Hypotension - physiopathology</subject><subject>Incidence</subject><subject>Information management</subject><subject>Injections, Spinal - adverse effects</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Midwifery</subject><subject>Mothers</subject><subject>Obstetrics</subject><subject>Orthopedics</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Random sampling</subject><subject>Statistical analysis</subject><subject>Statistical sampling</subject><subject>Statistical significance</subject><subject>Statistical tests</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWHxEm4QKoqDpUqVYLCreXDeOMqawc7WbHvw4PisNuqi3qBcpHY883_x-OZonhO8JKwmry7DlP0sl8OwcMSU8oxww-KY9IyuuAUs4d3vo-KJyldY1yxhvPHxREjDcO4Lo-L31cdILAW9JhQsMiloGR0GklvULcdIO6WahrcRmrpPKDg0VqOMLujDtbBbL1cZ0Z30q8goSGkEaXBzXHpIY0dJCeRDRFBn43cBpCGJCNIjwz0eR2379EpGmJIww0QuhCzzDiZ7dPikZV9gmf790nx_dPHq7Mvi4vLz-dnpxcLzVs6LigxWhttgRhjqeK6AYyVVaSlNVhGFZiS5YAkSimtq4rVTWMqy1qLaUMlOyle7nSHPiSxL3ASlNGKtlVT1pk43xEmyGsxRLeWcSuCdOLvRogrIePodA8CcwWKaGhKTEtSMclLrmraEDAAsp3dPuzdJrUGo8GPUfYHoocR7zqxChvBW1zXLc0Cb_YCMfyccp3F2iUNfZ-LHqb5vxmhVb7xKqOv_kHvP92eWsl8AOdtyL56FhWnHDdlxXmNM7W8h8qPgdwFuRuty_sHCW8PEjIzwq9xJaeUxPm3r__PXv44ZF_fYTuQ_dil0E-jCz4dguUO1LnBUgR7W2SCxTxMN9UQ8zCJ_TDltBd3L-g26WZ62B-seB7x</recordid><startdate>20191212</startdate><enddate>20191212</enddate><creator>Helill, Shamill Eanga</creator><creator>Sahile, Wossenyeleh Admasu</creator><creator>Abdo, Ritbano Ahmed</creator><creator>Wolde, Getahun Dendir</creator><creator>Halil, Hassen Mosa</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2867-7526</orcidid></search><sort><creationdate>20191212</creationdate><title>The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study</title><author>Helill, Shamill Eanga ; Sahile, Wossenyeleh Admasu ; Abdo, Ritbano Ahmed ; Wolde, Getahun Dendir ; Halil, Hassen Mosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-21dccdcfe1ddf2b6c8e00bfb1927ef32bed43f2ba1bbbcc553788d5f39f0282a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Analysis</topic><topic>Anesthesia</topic><topic>Anesthesia, Obstetrical</topic><topic>Anesthesia, Spinal - adverse effects</topic><topic>Anesthesiology</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Bupivacaine</topic><topic>Bupivacaine - administration & dosage</topic><topic>Bupivacaine - adverse effects</topic><topic>Cesarean section</topic><topic>Cesarean Section - adverse effects</topic><topic>Cesarean Section - methods</topic><topic>Chi-square test</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Computer and Information Sciences</topic><topic>Data analysis</topic><topic>Data collection</topic><topic>Elective Surgical Procedures - adverse effects</topic><topic>Ethiopia</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Health sciences</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>Hemodynamics - drug effects</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypotension</topic><topic>Hypotension - chemically induced</topic><topic>Hypotension - physiopathology</topic><topic>Incidence</topic><topic>Information management</topic><topic>Injections, Spinal - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helill, Shamill Eanga</au><au>Sahile, Wossenyeleh Admasu</au><au>Abdo, Ritbano Ahmed</au><au>Wolde, Getahun Dendir</au><au>Halil, Hassen Mosa</au><au>Farag, Ehab</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-12-12</date><risdate>2019</risdate><volume>14</volume><issue>12</issue><spage>e0226030</spage><epage>e0226030</epage><pages>e0226030-e0226030</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Spinal anesthesia is a form of regional anesthesia frequently used in various lower abdominal, orthopedic, obstetric operations such as a cesarean delivery. The most common local anesthetic used for spinal anesthesia in obstetric and non-obstetric surgery is bupivacaine which can be utilized as an isobaric or hyperbaric solution, producing differences in maternal hemodynamic changes. Against this backdrop, the study aims to compare the effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic alterations after administering spinal anesthesia for elective cesarean delivery at Gandhi Memorial Hospital, Addis Ababa, Ethiopia.
A hospital-based prospective cohort study design was employed for the period December 1, 2017 to January 30, 2018. A total of 100 parturient were involved, with one group exposed to isobaric bupivacaine and the other to hyperbaric bupivacaine to observe their effects on maternal hemodynamic changes post spinal anesthesia. The participants were selected through systematic random sampling. Data analysis was performed using SPSS (version 20) through descriptive statistic, independent sample t-test, Mann-Whitney U-test, Fisher's exact test, and Chi-square test were used. P values of <0.05 was assumed as statistically significant for all tests.
The incidence of hypotension was found to be greater in isobaric than hyperbaric groups (82% vs. 60% respectively; p = 0.015). No statistical significant differences were found in mean arterial pressure value at baseline, but, statistically significant changes were observed among the groups (p <0.05) at all study timing after spinal anesthesia, except at 30thmin. No statistically significant differences were seen in the mean heart rate variability after spinal anesthesia at all periods, except the 15th minute (p = 0.033). A greater rate of vasopressor was used in the isobaric group as compared to the hyperbaric group (36% vs. 14% respectively; p = 0.011).
Baricity is a significant factor in maternal hemodynamic changes in the parturient for elective cesarean section. Isobaric bupivacaine produces greater change in blood pressure and incidence of hypotension and entails a greater vasopressor requirement than hyperbaric bupivacaine after spinal anesthesia for elective cesarean section.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31830074</pmid><doi>10.1371/journal.pone.0226030</doi><tpages>e0226030</tpages><orcidid>https://orcid.org/0000-0003-2867-7526</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2019-12, Vol.14 (12), p.e0226030-e0226030 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2325295847 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Adult Analysis Anesthesia Anesthesia, Obstetrical Anesthesia, Spinal - adverse effects Anesthesiology Blood pressure Blood Pressure - drug effects Bupivacaine Bupivacaine - administration & dosage Bupivacaine - adverse effects Cesarean section Cesarean Section - adverse effects Cesarean Section - methods Chi-square test Cohort analysis Cohort Studies Computer and Information Sciences Data analysis Data collection Elective Surgical Procedures - adverse effects Ethiopia Female Health risk assessment Health sciences Heart rate Hemodynamics Hemodynamics - drug effects Hospitals Humans Hypotension Hypotension - chemically induced Hypotension - physiopathology Incidence Information management Injections, Spinal - adverse effects Medicine Medicine and Health Sciences Midwifery Mothers Obstetrics Orthopedics Pregnancy Prospective Studies Random sampling Statistical analysis Statistical sampling Statistical significance Statistical tests Surgery Treatment Outcome Young Adult |
| title | The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T00%3A50%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20isobaric%20and%20hyperbaric%20bupivacaine%20on%20maternal%20hemodynamic%20changes%20post%20spinal%20anesthesia%20for%20elective%20cesarean%20delivery:%20A%20prospective%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Helill,%20Shamill%20Eanga&rft.date=2019-12-12&rft.volume=14&rft.issue=12&rft.spage=e0226030&rft.epage=e0226030&rft.pages=e0226030-e0226030&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0226030&rft_dat=%3Cgale_plos_%3EA608456670%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2325295847&rft_id=info:pmid/31830074&rft_galeid=A608456670&rft_doaj_id=oai_doaj_org_article_06beb1ce84024153a646b7281edeea9a&rfr_iscdi=true |