Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population
Given the significant population diversity in genetic variation, we aimed to investigate whether single nucleotide polymorphisms (SNPs) previously identified in studies of colorectal cancer (CRC) susceptibility were also relevant to the population of the Basque Country (North of Spain). We genotyped...
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| creator | Alegria-Lertxundi, Iker Aguirre, Carmelo Bujanda, Luis Fernández, Francisco Javier Polo, Francisco Ordovás, José M Etxezarraga, M Carmen Zabalza, Iñaki Larzabal, Mikel Portillo, Isabel de Pancorbo, Marian M Palencia-Madrid, Leire Rocandio, Ana M Arroyo-Izaga, Marta |
| description | Given the significant population diversity in genetic variation, we aimed to investigate whether single nucleotide polymorphisms (SNPs) previously identified in studies of colorectal cancer (CRC) susceptibility were also relevant to the population of the Basque Country (North of Spain). We genotyped 230 CRC cases and 230 healthy controls for 48 previously reported CRC-susceptibility SNPs. Only the rs6687758 in DUPS10 exhibited a statistically significant association with CRC risk based on the crude analysis. The rs6687758 AG genotype conferred about 2.13-fold increased risk for CRC compared to the AA genotype. Moreover, we found significant associations in cases between smoking status, physical activity, and the rs6687758 SNP. The results of a Genetic Risk Score (GRS) showed that the risk alleles were more frequent in cases than controls and the score was associated with CRC in crude analysis. In conclusion, we have confirmed a CRC susceptibility locus and the existence of associations between modifiable factors and the rs6687758 SNP; moreover, the GRS was associated with CRC. However, further experimental validations are needed to establish the role of this SNP, the function of the gene identified, as well as the contribution of the interaction between environmental factors and this locusto the risk of CRC. |
| doi_str_mv | 10.1371/journal.pone.0225779 |
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We genotyped 230 CRC cases and 230 healthy controls for 48 previously reported CRC-susceptibility SNPs. Only the rs6687758 in DUPS10 exhibited a statistically significant association with CRC risk based on the crude analysis. The rs6687758 AG genotype conferred about 2.13-fold increased risk for CRC compared to the AA genotype. Moreover, we found significant associations in cases between smoking status, physical activity, and the rs6687758 SNP. The results of a Genetic Risk Score (GRS) showed that the risk alleles were more frequent in cases than controls and the score was associated with CRC in crude analysis. In conclusion, we have confirmed a CRC susceptibility locus and the existence of associations between modifiable factors and the rs6687758 SNP; moreover, the GRS was associated with CRC. However, further experimental validations are needed to establish the role of this SNP, the function of the gene identified, as well as the contribution of the interaction between environmental factors and this locusto the risk of CRC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0225779</identifier><identifier>PMID: 31821333</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol use ; Alleles ; Analysis ; Basque people ; Biology and Life Sciences ; Cancer ; Cancer research ; Case-Control Studies ; Chromosomes ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; Disease susceptibility ; Environmental factors ; Exercise ; Female ; Food ; Gastroenterology ; Genes ; Genetic aspects ; Genetic Association Studies ; Genetic diversity ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genomes ; Genomics ; Health risk assessment ; Health services ; Hospitals ; Humans ; Male ; Medical screening ; Medicine and Health Sciences ; Meta-analysis ; Middle Aged ; Nucleotides ; Nutrition research ; Pathology ; Pharmacy ; Physical activity ; Physical fitness ; Polymorphism, Single Nucleotide - genetics ; Population ; Population genetics ; Population studies ; Risk ; Risk Factors ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Smoking ; Spain ; Statistical analysis ; Studies ; Susceptibility</subject><ispartof>PloS one, 2019-12, Vol.14 (12), p.e0225779</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Alegria-Lertxundi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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However, further experimental validations are needed to establish the role of this SNP, the function of the gene identified, as well as the contribution of the interaction between environmental factors and this locusto the risk of CRC.</description><subject>Alcohol use</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Basque people</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Case-Control Studies</subject><subject>Chromosomes</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Disease susceptibility</subject><subject>Environmental factors</subject><subject>Exercise</subject><subject>Female</subject><subject>Food</subject><subject>Gastroenterology</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic 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Luis</au><au>Fernández, Francisco Javier</au><au>Polo, Francisco</au><au>Ordovás, José M</au><au>Etxezarraga, M Carmen</au><au>Zabalza, Iñaki</au><au>Larzabal, Mikel</au><au>Portillo, Isabel</au><au>de Pancorbo, Marian M</au><au>Palencia-Madrid, Leire</au><au>Rocandio, Ana M</au><au>Arroyo-Izaga, Marta</au><au>Xue, Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-12-10</date><risdate>2019</risdate><volume>14</volume><issue>12</issue><spage>e0225779</spage><pages>e0225779-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Given the significant population diversity in genetic variation, we aimed to investigate whether single nucleotide polymorphisms (SNPs) previously identified in studies of colorectal cancer (CRC) susceptibility were also relevant to the population of the Basque Country (North of Spain). We genotyped 230 CRC cases and 230 healthy controls for 48 previously reported CRC-susceptibility SNPs. Only the rs6687758 in DUPS10 exhibited a statistically significant association with CRC risk based on the crude analysis. The rs6687758 AG genotype conferred about 2.13-fold increased risk for CRC compared to the AA genotype. Moreover, we found significant associations in cases between smoking status, physical activity, and the rs6687758 SNP. The results of a Genetic Risk Score (GRS) showed that the risk alleles were more frequent in cases than controls and the score was associated with CRC in crude analysis. In conclusion, we have confirmed a CRC susceptibility locus and the existence of associations between modifiable factors and the rs6687758 SNP; moreover, the GRS was associated with CRC. However, further experimental validations are needed to establish the role of this SNP, the function of the gene identified, as well as the contribution of the interaction between environmental factors and this locusto the risk of CRC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31821333</pmid><doi>10.1371/journal.pone.0225779</doi><tpages>e0225779</tpages><orcidid>https://orcid.org/0000-0001-5592-4241</orcidid><orcidid>https://orcid.org/0000-0002-4353-9968</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_2323437011 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alcohol use Alleles Analysis Basque people Biology and Life Sciences Cancer Cancer research Case-Control Studies Chromosomes Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Disease susceptibility Environmental factors Exercise Female Food Gastroenterology Genes Genetic aspects Genetic Association Studies Genetic diversity Genetic polymorphisms Genetic Predisposition to Disease Genomes Genomics Health risk assessment Health services Hospitals Humans Male Medical screening Medicine and Health Sciences Meta-analysis Middle Aged Nucleotides Nutrition research Pathology Pharmacy Physical activity Physical fitness Polymorphism, Single Nucleotide - genetics Population Population genetics Population studies Risk Risk Factors Single nucleotide polymorphisms Single-nucleotide polymorphism Smoking Spain Statistical analysis Studies Susceptibility |
| title | Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T21%3A15%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Single%20nucleotide%20polymorphisms%20associated%20with%20susceptibility%20for%20development%20of%20colorectal%20cancer:%20Case-control%20study%20in%20a%20Basque%20population&rft.jtitle=PloS%20one&rft.au=Alegria-Lertxundi,%20Iker&rft.date=2019-12-10&rft.volume=14&rft.issue=12&rft.spage=e0225779&rft.pages=e0225779-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0225779&rft_dat=%3Cgale_plos_%3EA608122701%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2323437011&rft_id=info:pmid/31821333&rft_galeid=A608122701&rft_doaj_id=oai_doaj_org_article_0e342d895c4145efa23537deb588f48a&rfr_iscdi=true |