Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep
Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to det...
Gespeichert in:
| Veröffentlicht in: | PloS one 2019-11, Vol.14 (11), p.e0214346 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 11 |
| container_start_page | e0214346 |
| container_title | PloS one |
| container_volume | 14 |
| creator | Banos, Georgios Clark, Emily L Bush, Stephen J Dutta, Prasun Bramis, Georgios Arsenos, Georgios Hume, David A Psifidi, Androniki |
| description | Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to determine the feasibility of a concomitant genetic improvement programme for enhanced milk production and resistance to mastitis. Individual records for milk yield, and four mastitis-related traits (milk somatic cell count, California Mastitis Test score, total viable bacterial count in milk and clinical mastitis presence) were collected monthly throughout lactation for 609 ewes of the Chios breed. All ewes were genotyped with a mastitis specific custom-made 960 single nucleotide polymorphism (SNP) array. We performed targeted genomic association studies, (co)variance component estimation and pathway enrichment analysis, and characterised gene expression levels and the extent of allelic expression imbalance. Presence of heritable variation for milk yield was confirmed. There was no significant genetic correlation between milk yield and mastitis traits. Environmental factors appeared to favour both milk production and udder health. There were no overlapping of SNPs associated with mastitis resistance and milk yield in Chios sheep. Furthermore, four distinct Quantitative Trait Loci (QTLs) affecting milk yield were detected on chromosomes 2, 12, 16 and 19, in locations other than those previously identified to affect mastitis resistance. Five genes (DNAJA1, GHR, LYPLA1, NUP35 and OXCT1) located within the QTL regions were highly expressed in both the mammary gland and milk transcriptome, suggesting involvement in milk synthesis and production. Furthermore, the expression of two of these genes (NUP35 and OXCT1) was enriched in immune tissues implying a potentially pleiotropic effect or likely role in milk production during udder infection, which needs to be further elucidated in future studies. In conclusion, the absence of genetic antagonism between milk yield and mastitis resistance suggests that simultaneous genetic improvement of both traits be achievable. |
| doi_str_mv | 10.1371/journal.pone.0214346 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2317922958</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A606746136</galeid><doaj_id>oai_doaj_org_article_ea2e3de6da8849c6b3dd5343fddce981</doaj_id><sourcerecordid>A606746136</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-290329abae6f8c56cc085856dcb5cb93cecff10de509ab453bf784f78b45817a3</originalsourceid><addsrcrecordid>eNqNk9-K1DAUxoso7rr6BqIFQfBixrRp0_RGWBZdBxYW_Hcb0uR0JmubdJN0cR7Cd_bMTHeZgoKU0sPp7_uSfs1JkpcZWWa0yt7fuNFb2S0HZ2FJ8qygBXuUnGY1zRcsJ_TxUX2SPAvhhpCScsaeJic0q1hJK36a_L4EC9GoVFqdrsG6fl_LbhsgpKPV4Adj07iBtAUZTGM6E7epa1PlrEI6Sht3wr2J6Qfv7qAH7CHSm-5nujXQ6b19L0M00YTUQzABhQpS9NbS-G0aNgDD8-RJK7sAL6bnWfL908dvF58XV9eXq4vzq4VidR4XeU1oXstGAmu5KplShJe8ZFo1pWpqqkC1bUY0lASpoqRNW_ECb6x5Vkl6lrw--A6dC2JKMogcc6nzvC45EqsDoZ28EYM3vfRb4aQR-4bzayE9fnIHAmQOVAPTkvOiVqyhWpe0oK3WCmqeodeHabWx6QGbNnrZzUznb6zZiLW7E4xXjBcEDd5MBt7djhDiP7Y8UWuJuzK2dWimehOUOGeEVQXLKENq-RcKLw346_EstQb7M8G7mQCZCL_iWo4hiNXXL__PXv-Ys2-P2A3ILm6C68ZonA1zsDiAyrsQPLQPyWVE7EbhPg2xGwUxjQLKXh2n_iC6P_v0D6B-CEk</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2317922958</pqid></control><display><type>article</type><title>Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Banos, Georgios ; Clark, Emily L ; Bush, Stephen J ; Dutta, Prasun ; Bramis, Georgios ; Arsenos, Georgios ; Hume, David A ; Psifidi, Androniki</creator><contributor>Mateescu, Raluca</contributor><creatorcontrib>Banos, Georgios ; Clark, Emily L ; Bush, Stephen J ; Dutta, Prasun ; Bramis, Georgios ; Arsenos, Georgios ; Hume, David A ; Psifidi, Androniki ; Mateescu, Raluca</creatorcontrib><description>Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to determine the feasibility of a concomitant genetic improvement programme for enhanced milk production and resistance to mastitis. Individual records for milk yield, and four mastitis-related traits (milk somatic cell count, California Mastitis Test score, total viable bacterial count in milk and clinical mastitis presence) were collected monthly throughout lactation for 609 ewes of the Chios breed. All ewes were genotyped with a mastitis specific custom-made 960 single nucleotide polymorphism (SNP) array. We performed targeted genomic association studies, (co)variance component estimation and pathway enrichment analysis, and characterised gene expression levels and the extent of allelic expression imbalance. Presence of heritable variation for milk yield was confirmed. There was no significant genetic correlation between milk yield and mastitis traits. Environmental factors appeared to favour both milk production and udder health. There were no overlapping of SNPs associated with mastitis resistance and milk yield in Chios sheep. Furthermore, four distinct Quantitative Trait Loci (QTLs) affecting milk yield were detected on chromosomes 2, 12, 16 and 19, in locations other than those previously identified to affect mastitis resistance. Five genes (DNAJA1, GHR, LYPLA1, NUP35 and OXCT1) located within the QTL regions were highly expressed in both the mammary gland and milk transcriptome, suggesting involvement in milk synthesis and production. Furthermore, the expression of two of these genes (NUP35 and OXCT1) was enriched in immune tissues implying a potentially pleiotropic effect or likely role in milk production during udder infection, which needs to be further elucidated in future studies. In conclusion, the absence of genetic antagonism between milk yield and mastitis resistance suggests that simultaneous genetic improvement of both traits be achievable.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0214346</identifier><identifier>PMID: 31765378</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animal lactation ; Animal welfare ; Animals ; Antagonism ; Apoptosis ; Biology and Life Sciences ; California mastitis test ; Cattle ; Chromosomes ; Dairy industry ; Dairy products industry ; Dairying ; EDTA ; Environmental factors ; Feasibility Studies ; Female ; Future predictions ; Gene expression ; Gene mapping ; Genes ; Genetic analysis ; Genetic improvement ; Genetic polymorphisms ; Genetic research ; Genetics ; Genomic analysis ; Genomics ; Goats ; Lactation ; Lactation - genetics ; Lactation - physiology ; Mammary gland ; Mammary glands ; Mastitis ; Mastitis - genetics ; Mastitis - veterinary ; Medicine and Health Sciences ; Milk ; Milk production ; Nucleotides ; Oligonucleotide Array Sequence Analysis ; Polymorphism ; Polymorphism, Single Nucleotide ; Quantitative genetics ; Quantitative Trait Loci ; Selective Breeding ; Sheep ; Sheep Diseases - genetics ; Sheep, Domestic - classification ; Sheep, Domestic - genetics ; Sheep, Domestic - physiology ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Species Specificity ; Udder ; Veterinary colleges ; Veterinary medicine ; Yield</subject><ispartof>PloS one, 2019-11, Vol.14 (11), p.e0214346</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Banos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Banos et al 2019 Banos et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-290329abae6f8c56cc085856dcb5cb93cecff10de509ab453bf784f78b45817a3</citedby><cites>FETCH-LOGICAL-c692t-290329abae6f8c56cc085856dcb5cb93cecff10de509ab453bf784f78b45817a3</cites><orcidid>0000-0001-9341-2562 ; 0000-0001-7271-7180 ; 0000-0003-4095-1452</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876840/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876840/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53768,53770,79345,79346</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31765378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mateescu, Raluca</contributor><creatorcontrib>Banos, Georgios</creatorcontrib><creatorcontrib>Clark, Emily L</creatorcontrib><creatorcontrib>Bush, Stephen J</creatorcontrib><creatorcontrib>Dutta, Prasun</creatorcontrib><creatorcontrib>Bramis, Georgios</creatorcontrib><creatorcontrib>Arsenos, Georgios</creatorcontrib><creatorcontrib>Hume, David A</creatorcontrib><creatorcontrib>Psifidi, Androniki</creatorcontrib><title>Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to determine the feasibility of a concomitant genetic improvement programme for enhanced milk production and resistance to mastitis. Individual records for milk yield, and four mastitis-related traits (milk somatic cell count, California Mastitis Test score, total viable bacterial count in milk and clinical mastitis presence) were collected monthly throughout lactation for 609 ewes of the Chios breed. All ewes were genotyped with a mastitis specific custom-made 960 single nucleotide polymorphism (SNP) array. We performed targeted genomic association studies, (co)variance component estimation and pathway enrichment analysis, and characterised gene expression levels and the extent of allelic expression imbalance. Presence of heritable variation for milk yield was confirmed. There was no significant genetic correlation between milk yield and mastitis traits. Environmental factors appeared to favour both milk production and udder health. There were no overlapping of SNPs associated with mastitis resistance and milk yield in Chios sheep. Furthermore, four distinct Quantitative Trait Loci (QTLs) affecting milk yield were detected on chromosomes 2, 12, 16 and 19, in locations other than those previously identified to affect mastitis resistance. Five genes (DNAJA1, GHR, LYPLA1, NUP35 and OXCT1) located within the QTL regions were highly expressed in both the mammary gland and milk transcriptome, suggesting involvement in milk synthesis and production. Furthermore, the expression of two of these genes (NUP35 and OXCT1) was enriched in immune tissues implying a potentially pleiotropic effect or likely role in milk production during udder infection, which needs to be further elucidated in future studies. In conclusion, the absence of genetic antagonism between milk yield and mastitis resistance suggests that simultaneous genetic improvement of both traits be achievable.</description><subject>Analysis</subject><subject>Animal lactation</subject><subject>Animal welfare</subject><subject>Animals</subject><subject>Antagonism</subject><subject>Apoptosis</subject><subject>Biology and Life Sciences</subject><subject>California mastitis test</subject><subject>Cattle</subject><subject>Chromosomes</subject><subject>Dairy industry</subject><subject>Dairy products industry</subject><subject>Dairying</subject><subject>EDTA</subject><subject>Environmental factors</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Future predictions</subject><subject>Gene expression</subject><subject>Gene mapping</subject><subject>Genes</subject><subject>Genetic analysis</subject><subject>Genetic improvement</subject><subject>Genetic polymorphisms</subject><subject>Genetic research</subject><subject>Genetics</subject><subject>Genomic analysis</subject><subject>Genomics</subject><subject>Goats</subject><subject>Lactation</subject><subject>Lactation - genetics</subject><subject>Lactation - physiology</subject><subject>Mammary gland</subject><subject>Mammary glands</subject><subject>Mastitis</subject><subject>Mastitis - genetics</subject><subject>Mastitis - veterinary</subject><subject>Medicine and Health Sciences</subject><subject>Milk</subject><subject>Milk production</subject><subject>Nucleotides</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quantitative genetics</subject><subject>Quantitative Trait Loci</subject><subject>Selective Breeding</subject><subject>Sheep</subject><subject>Sheep Diseases - genetics</subject><subject>Sheep, Domestic - classification</subject><subject>Sheep, Domestic - genetics</subject><subject>Sheep, Domestic - physiology</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Species Specificity</subject><subject>Udder</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><subject>Yield</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-K1DAUxoso7rr6BqIFQfBixrRp0_RGWBZdBxYW_Hcb0uR0JmubdJN0cR7Cd_bMTHeZgoKU0sPp7_uSfs1JkpcZWWa0yt7fuNFb2S0HZ2FJ8qygBXuUnGY1zRcsJ_TxUX2SPAvhhpCScsaeJic0q1hJK36a_L4EC9GoVFqdrsG6fl_LbhsgpKPV4Adj07iBtAUZTGM6E7epa1PlrEI6Sht3wr2J6Qfv7qAH7CHSm-5nujXQ6b19L0M00YTUQzABhQpS9NbS-G0aNgDD8-RJK7sAL6bnWfL908dvF58XV9eXq4vzq4VidR4XeU1oXstGAmu5KplShJe8ZFo1pWpqqkC1bUY0lASpoqRNW_ECb6x5Vkl6lrw--A6dC2JKMogcc6nzvC45EqsDoZ28EYM3vfRb4aQR-4bzayE9fnIHAmQOVAPTkvOiVqyhWpe0oK3WCmqeodeHabWx6QGbNnrZzUznb6zZiLW7E4xXjBcEDd5MBt7djhDiP7Y8UWuJuzK2dWimehOUOGeEVQXLKENq-RcKLw346_EstQb7M8G7mQCZCL_iWo4hiNXXL__PXv-Ys2-P2A3ILm6C68ZonA1zsDiAyrsQPLQPyWVE7EbhPg2xGwUxjQLKXh2n_iC6P_v0D6B-CEk</recordid><startdate>20191125</startdate><enddate>20191125</enddate><creator>Banos, Georgios</creator><creator>Clark, Emily L</creator><creator>Bush, Stephen J</creator><creator>Dutta, Prasun</creator><creator>Bramis, Georgios</creator><creator>Arsenos, Georgios</creator><creator>Hume, David A</creator><creator>Psifidi, Androniki</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9341-2562</orcidid><orcidid>https://orcid.org/0000-0001-7271-7180</orcidid><orcidid>https://orcid.org/0000-0003-4095-1452</orcidid></search><sort><creationdate>20191125</creationdate><title>Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep</title><author>Banos, Georgios ; Clark, Emily L ; Bush, Stephen J ; Dutta, Prasun ; Bramis, Georgios ; Arsenos, Georgios ; Hume, David A ; Psifidi, Androniki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-290329abae6f8c56cc085856dcb5cb93cecff10de509ab453bf784f78b45817a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Animal lactation</topic><topic>Animal welfare</topic><topic>Animals</topic><topic>Antagonism</topic><topic>Apoptosis</topic><topic>Biology and Life Sciences</topic><topic>California mastitis test</topic><topic>Cattle</topic><topic>Chromosomes</topic><topic>Dairy industry</topic><topic>Dairy products industry</topic><topic>Dairying</topic><topic>EDTA</topic><topic>Environmental factors</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Future predictions</topic><topic>Gene expression</topic><topic>Gene mapping</topic><topic>Genes</topic><topic>Genetic analysis</topic><topic>Genetic improvement</topic><topic>Genetic polymorphisms</topic><topic>Genetic research</topic><topic>Genetics</topic><topic>Genomic analysis</topic><topic>Genomics</topic><topic>Goats</topic><topic>Lactation</topic><topic>Lactation - genetics</topic><topic>Lactation - physiology</topic><topic>Mammary gland</topic><topic>Mammary glands</topic><topic>Mastitis</topic><topic>Mastitis - genetics</topic><topic>Mastitis - veterinary</topic><topic>Medicine and Health Sciences</topic><topic>Milk</topic><topic>Milk production</topic><topic>Nucleotides</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quantitative genetics</topic><topic>Quantitative Trait Loci</topic><topic>Selective Breeding</topic><topic>Sheep</topic><topic>Sheep Diseases - genetics</topic><topic>Sheep, Domestic - classification</topic><topic>Sheep, Domestic - genetics</topic><topic>Sheep, Domestic - physiology</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Species Specificity</topic><topic>Udder</topic><topic>Veterinary colleges</topic><topic>Veterinary medicine</topic><topic>Yield</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banos, Georgios</creatorcontrib><creatorcontrib>Clark, Emily L</creatorcontrib><creatorcontrib>Bush, Stephen J</creatorcontrib><creatorcontrib>Dutta, Prasun</creatorcontrib><creatorcontrib>Bramis, Georgios</creatorcontrib><creatorcontrib>Arsenos, Georgios</creatorcontrib><creatorcontrib>Hume, David A</creatorcontrib><creatorcontrib>Psifidi, Androniki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banos, Georgios</au><au>Clark, Emily L</au><au>Bush, Stephen J</au><au>Dutta, Prasun</au><au>Bramis, Georgios</au><au>Arsenos, Georgios</au><au>Hume, David A</au><au>Psifidi, Androniki</au><au>Mateescu, Raluca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-11-25</date><risdate>2019</risdate><volume>14</volume><issue>11</issue><spage>e0214346</spage><pages>e0214346-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Milk yield is the most important dairy sheep trait and constitutes the key genetic improvement goal via selective breeding. Mastitis is one of the most prevalent diseases, significantly impacting on animal welfare, milk yield and quality, while incurring substantial costs. Our objectives were to determine the feasibility of a concomitant genetic improvement programme for enhanced milk production and resistance to mastitis. Individual records for milk yield, and four mastitis-related traits (milk somatic cell count, California Mastitis Test score, total viable bacterial count in milk and clinical mastitis presence) were collected monthly throughout lactation for 609 ewes of the Chios breed. All ewes were genotyped with a mastitis specific custom-made 960 single nucleotide polymorphism (SNP) array. We performed targeted genomic association studies, (co)variance component estimation and pathway enrichment analysis, and characterised gene expression levels and the extent of allelic expression imbalance. Presence of heritable variation for milk yield was confirmed. There was no significant genetic correlation between milk yield and mastitis traits. Environmental factors appeared to favour both milk production and udder health. There were no overlapping of SNPs associated with mastitis resistance and milk yield in Chios sheep. Furthermore, four distinct Quantitative Trait Loci (QTLs) affecting milk yield were detected on chromosomes 2, 12, 16 and 19, in locations other than those previously identified to affect mastitis resistance. Five genes (DNAJA1, GHR, LYPLA1, NUP35 and OXCT1) located within the QTL regions were highly expressed in both the mammary gland and milk transcriptome, suggesting involvement in milk synthesis and production. Furthermore, the expression of two of these genes (NUP35 and OXCT1) was enriched in immune tissues implying a potentially pleiotropic effect or likely role in milk production during udder infection, which needs to be further elucidated in future studies. In conclusion, the absence of genetic antagonism between milk yield and mastitis resistance suggests that simultaneous genetic improvement of both traits be achievable.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31765378</pmid><doi>10.1371/journal.pone.0214346</doi><tpages>e0214346</tpages><orcidid>https://orcid.org/0000-0001-9341-2562</orcidid><orcidid>https://orcid.org/0000-0001-7271-7180</orcidid><orcidid>https://orcid.org/0000-0003-4095-1452</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-11, Vol.14 (11), p.e0214346 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2317922958 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Animal lactation Animal welfare Animals Antagonism Apoptosis Biology and Life Sciences California mastitis test Cattle Chromosomes Dairy industry Dairy products industry Dairying EDTA Environmental factors Feasibility Studies Female Future predictions Gene expression Gene mapping Genes Genetic analysis Genetic improvement Genetic polymorphisms Genetic research Genetics Genomic analysis Genomics Goats Lactation Lactation - genetics Lactation - physiology Mammary gland Mammary glands Mastitis Mastitis - genetics Mastitis - veterinary Medicine and Health Sciences Milk Milk production Nucleotides Oligonucleotide Array Sequence Analysis Polymorphism Polymorphism, Single Nucleotide Quantitative genetics Quantitative Trait Loci Selective Breeding Sheep Sheep Diseases - genetics Sheep, Domestic - classification Sheep, Domestic - genetics Sheep, Domestic - physiology Single nucleotide polymorphisms Single-nucleotide polymorphism Species Specificity Udder Veterinary colleges Veterinary medicine Yield |
| title | Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T07%3A32%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20and%20genomic%20analyses%20underpin%20the%20feasibility%20of%20concomitant%20genetic%20improvement%20of%20milk%20yield%20and%20mastitis%20resistance%20in%20dairy%20sheep&rft.jtitle=PloS%20one&rft.au=Banos,%20Georgios&rft.date=2019-11-25&rft.volume=14&rft.issue=11&rft.spage=e0214346&rft.pages=e0214346-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0214346&rft_dat=%3Cgale_plos_%3EA606746136%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2317922958&rft_id=info:pmid/31765378&rft_galeid=A606746136&rft_doaj_id=oai_doaj_org_article_ea2e3de6da8849c6b3dd5343fddce981&rfr_iscdi=true |