Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
Derivatives of yeast cell wall (YCW) have been studied for their potential prebiotic effects. Recently, new purified and soluble preparations have been developed in an attempt to increase their biological actions. Two YCW preparations, one conventional and another with higher solubility of the manna...
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| creator | Theodoro, Stephanie de Souza Putarov, Thaila Cristina Tiemi, Caroline Volpe, Lara Mantovani de Oliveira, Carlos Alberto Ferreira Glória, Maria Beatriz de Abreu Carciofi, Aulus Cavalieri |
| description | Derivatives of yeast cell wall (YCW) have been studied for their potential prebiotic effects. Recently, new purified and soluble preparations have been developed in an attempt to increase their biological actions. Two YCW preparations, one conventional and another with higher solubility of the mannan oligosaccharide fraction, were evaluated on dogs. One food formulation was used, divided into the following treatments: CON-control, without yeast cell wall addition; YCW-addition of 0.3% of a conventional yeas cell wall extract; YCWs-addition of 0.3% of a yeast cell wall extract with high mannan oligosaccharide solubility. Twenty-four beagle dogs were used, eight per food, distributed on a block design. Blocks lasted 32 days, and TNF-a, IL-6, IL-10, ex vivo production of hydrogen peroxide and nitric oxide by peripheral neutrophils and monocytes, phagocytic index, and fecal IgA were evaluated at the beginning and end of each period. Additionally, nutrient digestibility, feces production and quality, and fermentation products were quantified. The results were evaluated by analysis of variance and compared using the Tukey test (P |
| doi_str_mv | 10.1371/journal.pone.0225659 |
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Recently, new purified and soluble preparations have been developed in an attempt to increase their biological actions. Two YCW preparations, one conventional and another with higher solubility of the mannan oligosaccharide fraction, were evaluated on dogs. One food formulation was used, divided into the following treatments: CON-control, without yeast cell wall addition; YCW-addition of 0.3% of a conventional yeas cell wall extract; YCWs-addition of 0.3% of a yeast cell wall extract with high mannan oligosaccharide solubility. Twenty-four beagle dogs were used, eight per food, distributed on a block design. Blocks lasted 32 days, and TNF-a, IL-6, IL-10, ex vivo production of hydrogen peroxide and nitric oxide by peripheral neutrophils and monocytes, phagocytic index, and fecal IgA were evaluated at the beginning and end of each period. Additionally, nutrient digestibility, feces production and quality, and fermentation products were quantified. The results were evaluated by analysis of variance and compared using the Tukey test (P<0.05), using the basal immunological parameters as a covariate. The inclusion of YCWs reduced fat digestibility (P<0.05), increased the concentration of butyrate and putrescine, and reduced lactate in feces (P<0.05), showing that mannan oligosaccharide solubilization resulted in higher fermentation of this compound and altered the metabolism of the gut microbiota. Lower IL-6 on serum was verified for dogs fed the YCWs diet (P<0.05), suggesting a reduction in the inflammatory activity of dogs. Higher phagocytic index was verified for peripheral monocytes after the intake of the YCW food, suggesting better innate immunity. In conclusion, the solubilization of the mannooligosaccharide fraction alters its interaction with gut microbiota and biological actions in animals, although both yeast cell wall preparations exhibited prebiotic effects on dogs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0225659</identifier><identifier>PMID: 31765439</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animal Feed - analysis ; Animals ; Biology and Life Sciences ; Cell Wall - metabolism ; Cell walls ; Digestibility ; Dogs ; Enzymes ; Esters ; Feces ; Feces - chemistry ; Female ; Fermentation ; Food ; Food intake ; Gastrointestinal Microbiome - drug effects ; Hydrogen ; Hydrogen peroxide ; Hydrogen Peroxide - metabolism ; Hydrogen production ; Immune system ; Immunity, Innate - drug effects ; Immunoglobulin A ; Immunology ; Inflammation ; Innate immunity ; Interleukin 10 ; Interleukin 6 ; Interleukin-6 - blood ; Intestinal microflora ; Lactic acid ; Leukocytes (neutrophilic) ; Male ; Mannan ; Mannans - chemistry ; Medicine and Health Sciences ; Metabolism ; Microbiota ; Microbiota (Symbiotic organisms) ; Monocytes ; Monocytes - cytology ; Monocytes - drug effects ; Monocytes - metabolism ; Nitric oxide ; Nitrogen oxides ; Nutrition ; Oligosaccharides ; Oligosaccharides - chemistry ; Oligosaccharides - pharmacology ; Pathogens ; Peroxides ; Phagocytes ; Physiological aspects ; Polyamines ; Prebiotics ; Probiotics ; Putrescine ; Saccharomyces cerevisiae - metabolism ; Shellfish ; Solubility ; Solubilization ; Surgery ; Tumor necrosis factor-α ; Variance analysis ; Veterinarians ; Veterinary medicine ; Yeast ; Yeasts</subject><ispartof>PloS one, 2019-11, Vol.14 (11), p.e0225659-e0225659</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Theodoro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Theodoro et al 2019 Theodoro et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4eaa91ea9eaf4b94181bee858563d5a5e6a892ce0598dd3dd6f6622b395d931f3</citedby><cites>FETCH-LOGICAL-c692t-4eaa91ea9eaf4b94181bee858563d5a5e6a892ce0598dd3dd6f6622b395d931f3</cites><orcidid>0000-0001-8075-458X ; 0000-0003-3859-3983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878821/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878821/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31765439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theodoro, Stephanie de Souza</creatorcontrib><creatorcontrib>Putarov, Thaila Cristina</creatorcontrib><creatorcontrib>Tiemi, Caroline</creatorcontrib><creatorcontrib>Volpe, Lara Mantovani</creatorcontrib><creatorcontrib>de Oliveira, Carlos Alberto Ferreira</creatorcontrib><creatorcontrib>Glória, Maria Beatriz de Abreu</creatorcontrib><creatorcontrib>Carciofi, Aulus Cavalieri</creatorcontrib><title>Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Derivatives of yeast cell wall (YCW) have been studied for their potential prebiotic effects. Recently, new purified and soluble preparations have been developed in an attempt to increase their biological actions. Two YCW preparations, one conventional and another with higher solubility of the mannan oligosaccharide fraction, were evaluated on dogs. One food formulation was used, divided into the following treatments: CON-control, without yeast cell wall addition; YCW-addition of 0.3% of a conventional yeas cell wall extract; YCWs-addition of 0.3% of a yeast cell wall extract with high mannan oligosaccharide solubility. Twenty-four beagle dogs were used, eight per food, distributed on a block design. Blocks lasted 32 days, and TNF-a, IL-6, IL-10, ex vivo production of hydrogen peroxide and nitric oxide by peripheral neutrophils and monocytes, phagocytic index, and fecal IgA were evaluated at the beginning and end of each period. Additionally, nutrient digestibility, feces production and quality, and fermentation products were quantified. The results were evaluated by analysis of variance and compared using the Tukey test (P<0.05), using the basal immunological parameters as a covariate. The inclusion of YCWs reduced fat digestibility (P<0.05), increased the concentration of butyrate and putrescine, and reduced lactate in feces (P<0.05), showing that mannan oligosaccharide solubilization resulted in higher fermentation of this compound and altered the metabolism of the gut microbiota. Lower IL-6 on serum was verified for dogs fed the YCWs diet (P<0.05), suggesting a reduction in the inflammatory activity of dogs. Higher phagocytic index was verified for peripheral monocytes after the intake of the YCW food, suggesting better innate immunity. In conclusion, the solubilization of the mannooligosaccharide fraction alters its interaction with gut microbiota and biological actions in animals, although both yeast cell wall preparations exhibited prebiotic effects on dogs.</description><subject>Analysis</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Cell Wall - metabolism</subject><subject>Cell walls</subject><subject>Digestibility</subject><subject>Dogs</subject><subject>Enzymes</subject><subject>Esters</subject><subject>Feces</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Fermentation</subject><subject>Food</subject><subject>Food intake</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Hydrogen</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Hydrogen production</subject><subject>Immune system</subject><subject>Immunity, Innate - drug effects</subject><subject>Immunoglobulin A</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Innate immunity</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Intestinal microflora</subject><subject>Lactic acid</subject><subject>Leukocytes (neutrophilic)</subject><subject>Male</subject><subject>Mannan</subject><subject>Mannans - chemistry</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Monocytes</subject><subject>Monocytes - cytology</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>Nitric oxide</subject><subject>Nitrogen oxides</subject><subject>Nutrition</subject><subject>Oligosaccharides</subject><subject>Oligosaccharides - chemistry</subject><subject>Oligosaccharides - pharmacology</subject><subject>Pathogens</subject><subject>Peroxides</subject><subject>Phagocytes</subject><subject>Physiological aspects</subject><subject>Polyamines</subject><subject>Prebiotics</subject><subject>Probiotics</subject><subject>Putrescine</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Shellfish</subject><subject>Solubility</subject><subject>Solubilization</subject><subject>Surgery</subject><subject>Tumor necrosis factor-α</subject><subject>Variance analysis</subject><subject>Veterinarians</subject><subject>Veterinary medicine</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk2-L1DAQxoso3nn6DUQLguiLXZukSZM3wnGcunBw4L-3YdpOd3N0m16SqvvtTXd7x1buhRTaMPk9z2SmmSR5SbIlYQX5cGMH10G77G2Hy4xSLrh6lJwSxehC0Iw9PlqfJM-8v8kyzqQQT5MTRgrBc6ZOE3PZNFgFn9omDRtMvW2H0rQm7MbIDsGHtMK2TX9DfPUOe3AQjO2iohsVxqW9DdgFA_v90thgqriyPbpg0KemS2u79s-TJw20Hl9M37Pkx6fL7xdfFlfXn1cX51eLSigaFjkCKIKgEJq8VDmRpESUXHLBag4cBUhFK8y4knXN6lo0QlBaMsVrxUjDzpLXB9--tV5PXfKaxpoVkVmuIrE6ELWFG907swW30xaM3gesW2uIR69a1BJVU2Od5YxEJZcgC1GVnFNAKkQD0evjlG0ot1hXsREO2pnpfKczG722v7SQhZSURIN3k4GztwP6oLfGjx2HDu2wP7csGC9kHtE3_6APVzdRa4gFmK6xMW81mupzkYkiFyQf0y4foOJT49ZU8Uo1JsZngvczQWQC_glrGLzXq29f_5-9_jln3x6xG4Q2bMZLuL9jczA_gJWz3jts7ptMMj1OxF039DgRepqIKHt1_IPuRXcjwP4CgJ4Hcw</recordid><startdate>20191125</startdate><enddate>20191125</enddate><creator>Theodoro, Stephanie de Souza</creator><creator>Putarov, Thaila Cristina</creator><creator>Tiemi, Caroline</creator><creator>Volpe, Lara Mantovani</creator><creator>de Oliveira, Carlos Alberto Ferreira</creator><creator>Glória, Maria Beatriz de Abreu</creator><creator>Carciofi, Aulus Cavalieri</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8075-458X</orcidid><orcidid>https://orcid.org/0000-0003-3859-3983</orcidid></search><sort><creationdate>20191125</creationdate><title>Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs</title><author>Theodoro, Stephanie de Souza ; Putarov, Thaila Cristina ; Tiemi, Caroline ; Volpe, Lara Mantovani ; de Oliveira, Carlos Alberto Ferreira ; Glória, Maria Beatriz de Abreu ; Carciofi, Aulus Cavalieri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4eaa91ea9eaf4b94181bee858563d5a5e6a892ce0598dd3dd6f6622b395d931f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Animal Feed - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theodoro, Stephanie de Souza</au><au>Putarov, Thaila Cristina</au><au>Tiemi, Caroline</au><au>Volpe, Lara Mantovani</au><au>de Oliveira, Carlos Alberto Ferreira</au><au>Glória, Maria Beatriz de Abreu</au><au>Carciofi, Aulus Cavalieri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-11-25</date><risdate>2019</risdate><volume>14</volume><issue>11</issue><spage>e0225659</spage><epage>e0225659</epage><pages>e0225659-e0225659</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Derivatives of yeast cell wall (YCW) have been studied for their potential prebiotic effects. Recently, new purified and soluble preparations have been developed in an attempt to increase their biological actions. Two YCW preparations, one conventional and another with higher solubility of the mannan oligosaccharide fraction, were evaluated on dogs. One food formulation was used, divided into the following treatments: CON-control, without yeast cell wall addition; YCW-addition of 0.3% of a conventional yeas cell wall extract; YCWs-addition of 0.3% of a yeast cell wall extract with high mannan oligosaccharide solubility. Twenty-four beagle dogs were used, eight per food, distributed on a block design. Blocks lasted 32 days, and TNF-a, IL-6, IL-10, ex vivo production of hydrogen peroxide and nitric oxide by peripheral neutrophils and monocytes, phagocytic index, and fecal IgA were evaluated at the beginning and end of each period. Additionally, nutrient digestibility, feces production and quality, and fermentation products were quantified. The results were evaluated by analysis of variance and compared using the Tukey test (P<0.05), using the basal immunological parameters as a covariate. The inclusion of YCWs reduced fat digestibility (P<0.05), increased the concentration of butyrate and putrescine, and reduced lactate in feces (P<0.05), showing that mannan oligosaccharide solubilization resulted in higher fermentation of this compound and altered the metabolism of the gut microbiota. Lower IL-6 on serum was verified for dogs fed the YCWs diet (P<0.05), suggesting a reduction in the inflammatory activity of dogs. Higher phagocytic index was verified for peripheral monocytes after the intake of the YCW food, suggesting better innate immunity. In conclusion, the solubilization of the mannooligosaccharide fraction alters its interaction with gut microbiota and biological actions in animals, although both yeast cell wall preparations exhibited prebiotic effects on dogs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31765439</pmid><doi>10.1371/journal.pone.0225659</doi><tpages>e0225659</tpages><orcidid>https://orcid.org/0000-0001-8075-458X</orcidid><orcidid>https://orcid.org/0000-0003-3859-3983</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-11, Vol.14 (11), p.e0225659-e0225659 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2317918049 |
| source | PLoS; MEDLINE; EZB Free E-Journals; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animal Feed - analysis Animals Biology and Life Sciences Cell Wall - metabolism Cell walls Digestibility Dogs Enzymes Esters Feces Feces - chemistry Female Fermentation Food Food intake Gastrointestinal Microbiome - drug effects Hydrogen Hydrogen peroxide Hydrogen Peroxide - metabolism Hydrogen production Immune system Immunity, Innate - drug effects Immunoglobulin A Immunology Inflammation Innate immunity Interleukin 10 Interleukin 6 Interleukin-6 - blood Intestinal microflora Lactic acid Leukocytes (neutrophilic) Male Mannan Mannans - chemistry Medicine and Health Sciences Metabolism Microbiota Microbiota (Symbiotic organisms) Monocytes Monocytes - cytology Monocytes - drug effects Monocytes - metabolism Nitric oxide Nitrogen oxides Nutrition Oligosaccharides Oligosaccharides - chemistry Oligosaccharides - pharmacology Pathogens Peroxides Phagocytes Physiological aspects Polyamines Prebiotics Probiotics Putrescine Saccharomyces cerevisiae - metabolism Shellfish Solubility Solubilization Surgery Tumor necrosis factor-α Variance analysis Veterinarians Veterinary medicine Yeast Yeasts |
| title | Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A07%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20the%20solubility%20of%20yeast%20cell%20wall%20preparations%20on%20their%20potential%20prebiotic%20properties%20in%20dogs&rft.jtitle=PloS%20one&rft.au=Theodoro,%20Stephanie%20de%20Souza&rft.date=2019-11-25&rft.volume=14&rft.issue=11&rft.spage=e0225659&rft.epage=e0225659&rft.pages=e0225659-e0225659&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0225659&rft_dat=%3Cgale_plos_%3EA606746141%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2317918049&rft_id=info:pmid/31765439&rft_galeid=A606746141&rft_doaj_id=oai_doaj_org_article_8e9fded043104958a876cb552ae266fa&rfr_iscdi=true |