$Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors$

Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors

Advances in genomic technologies and the development of targeted therapeutics are making the use of precision medicine increasingly possible. In this study, we explored whether precision medicine can be applied for the management of refractory/relapsed pediatric solid tumors by discovering actionabl...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0224227-e0224227
Hauptverfasser:	Lee, Ji Won, Kim, Nayoung K D, Lee, Soo Hyun, Cho, Hee Won, Ma, Youngeun, Ju, Hee Young, Yoo, Keon Hee, Sung, Ki Woong, Koo, Hong Hoe, Park, Woong-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alterations Anaplastic Lymphoma Kinase - antagonists & inhibitors Anaplastic Lymphoma Kinase - genetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biology Biology and Life Sciences Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - genetics Cancer Cancer genetics Child Child, Preschool Children Consortia Copy number Criminal investigation Crizotinib Deoxyribonucleic acid DNA DNA Copy Number Variations DNA Mutational Analysis DNA sequencing Drug development Drug Resistance, Neoplasm - genetics Exons - genetics Feasibility Studies Female Gene sequencing Genes Genetic aspects Genomes Genomics High-Throughput Nucleotide Sequencing Humans Infant Introns Lactams, Macrocyclic - pharmacology Lactams, Macrocyclic - therapeutic use Lorlatinib Lymphoma Lymphomas Male Medical prognosis Medicine Medicine and Health Sciences Molecular Targeted Therapy - methods Mutation Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - prevention & control Neoplasms - drug therapy Neoplasms - genetics Neuroblastoma Nucleotide sequence Oncology Patients Pediatrics Precision medicine Precision Medicine - methods Profiling Recurrence (Disease) Republic of Korea Research and Analysis Methods Solid tumors Technology Therapeutics Tumorigenesis Tumors Young Adult
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