ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells

Immune cell infiltration of tumors and the tumor microenvironment can be an important component for determining patient outcomes. For example, immune and stromal cell presence inferred by deconvolving patient gene expression data may help identify high risk patients or suggest a course of treatment....

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0224693-e0224693
Hauptverfasser:	Danziger, Samuel A, Gibbs, David L, Shmulevich, Ilya, McConnell, Mark, Trotter, Matthew W B, Schmitz, Frank, Reiss, David J, Ratushny, Alexander V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Algorithms Biochemistry Bioinformatics Biology Biology and Life Sciences Cluster Analysis Clustering Computational Biology - methods Datasets as Topic Deconvolution Gene expression Gene Expression Regulation, Neoplastic - immunology Genes Genetic research Genomes Genomics Humans Immune system Knowledge bases (artificial intelligence) Medicine and Health Sciences Metastases Multiple myeloma Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Novels Physical Sciences Research and Analysis Methods RNA sequencing RNA-Seq - methods Single-Cell Analysis - methods Software Support Vector Machine Tumor Microenvironment - genetics Tumor Microenvironment - immunology Tumors
Online-Zugang:	Volltext
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