Low affinity binding sites in an activating CRM mediate negative autoregulation of the Drosophila Hox gene Ultrabithorax

Specification of cell identity and the proper functioning of a mature cell depend on precise regulation of gene expression. Both binary ON/OFF regulation of transcription, as well as more fine-tuned control of transcription levels in the ON state, are required to define cell types. The Drosophila me...

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Veröffentlicht in:	PLoS genetics 2019-10, Vol.15 (10), p.e1008444
Hauptverfasser:	Delker, Rebecca K, Ranade, Vikram, Loker, Ryan, Voutev, Roumen, Mann, Richard S
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Animals, Genetically Modified Bias Binding sites Binding Sites - physiology Biochemistry Biology Biology and Life Sciences Biophysics Cofactors Customer relationship management Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Fate Gene expression Gene Expression Regulation, Developmental Gene regulation Genes Genes, Insect - physiology Genetic aspects Genetic engineering Genetic regulation Genomes Genomics Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeostasis - genetics HOX gene Insects Larva - growth & development Mutation Novels Proteins Regulatory Elements, Transcriptional - physiology Research and Analysis Methods Transcription Transcription (Genetics) Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Wings, Animal - embryology
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