The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression

E-cadherin complexes with the actin cytoskeleton via cytoplasmic catenins and maintains the functional characteristics and integrity of the epithelia in normal epithelial tissues. Lost expression of E-cadherin disrupts this complex resulting in loss of cell polarity, epithelial denudation and increa...

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Veröffentlicht in:	PLoS genetics 2019-10, Vol.15 (10), p.e1008451
Hauptverfasser:	Olson, Adam, Le, Vien, Aldahl, Joseph, Yu, Eun-Jeong, Hooker, Erika, He, Yongfeng, Lee, Dong-Hong, Kim, Won Kyung, Cardiff, Robert D, Geradts, Joseph, Sun, Zijie
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Analysis Androgens Animal models Animals Antigens Antigens, CD - genetics Antigens, CD - metabolism Apoptosis beta Catenin - genetics beta Catenin - metabolism Biology Biology and Life Sciences Cadherins - genetics Cadherins - metabolism Cancer metastasis Cell adhesion & migration Cell culture Cell growth Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - pathology Clonal deletion Cytoskeleton Development and progression Disease Models, Animal Disease Progression E-cadherin Epithelial Cells Epithelium Gene deletion Genetic engineering Genetic transformation Genetically modified organisms HEK293 Cells Humans Kinases Lesions Male Medicine and Health Sciences Metaplasia Metastases Mice Mice, Transgenic Muscle proteins Mutation Novels Organoids Permeability Phenotypes Physiological aspects Polarity Primary Cell Culture Prostate Prostate - cytology Prostate - pathology Prostate cancer Prostatic intraepithelial neoplasia Prostatic Intraepithelial Neoplasia - genetics Prostatic Intraepithelial Neoplasia - pathology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Research and Analysis Methods RNA polymerase RNA, Small Interfering Transcription Transformation Tumorigenesis Tumors β-Catenin
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