Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms

Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restri...

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Veröffentlicht in:	PLoS genetics 2019-10, Vol.15 (10), p.e1008410
Hauptverfasser:	Bahhir, Diana, Yalgin, Cagri, Ots, Liina, Järvinen, Sampsa, George, Jack, Naudí, Alba, Krama, Tatjana, Krams, Indrikis, Tamm, Mairi, Andjelković, Ana, Dufour, Eric, González de Cózar, Jose M, Gerards, Mike, Parhiala, Mikael, Pamplona, Reinald, Jacobs, Howard T, Jõers, Priit
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenosine Triphosphate - genetics AKT protein Animals Biology Biology and life sciences Carbohydrate Metabolism - genetics Carbohydrates - genetics Cellular Reprogramming - genetics Deactivation Deoxyribonucleic acid Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism DNA DNA methylation DNA Restriction Enzymes - genetics DNA, Mitochondrial - genetics Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Earth science Ecology Endonuclease Funding Gene expression Homeostasis Humans Insects Lipid metabolism Lipid peroxidation Medicine Metabolic Networks and Pathways - genetics Metabolic pathways Metabolism Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Novels Nucleases Oxidation Oxidation-reduction reactions Oxidative Phosphorylation Oxidative Stress - genetics Phenotypes Phosphorylation Physical Sciences Physiological aspects Post-translation Protein transport Proteins Pyruvic acid Research and Analysis Methods Scientific equipment industry Serine Survival analysis
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