Cell generation dynamics underlying naive T-cell homeostasis in adult humans

Thymic involution and proliferation of naive T cells both contribute to shaping the naive T-cell repertoire as humans age, but a clear understanding of the roles of each throughout a human life span has been difficult to determine. By measuring nuclear bomb test-derived 14C in genomic DNA, we determ...

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Veröffentlicht in:	PLoS biology 2019-10, Vol.17 (10), p.e3000383-e3000383
Hauptverfasser:	Mold, Jeff E, Réu, Pedro, Olin, Axel, Bernard, Samuel, Michaëlsson, Jakob, Rane, Sanket, Yates, Andrew, Khosravi, Azadeh, Salehpour, Mehran, Possnert, Göran, Brodin, Petter, Frisén, Jonas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aging Aging - genetics Aging - immunology Authorship Biology and Life Sciences CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell activation Cell Lineage - genetics Cell Lineage - immunology Cell Proliferation Cloning Cytometry Deoxyribonucleic acid DNA Dynamical Systems Female Funding Gene Expression Regulation, Developmental Growth factors Homeostasis Homeostasis - genetics Homeostasis - immunology Humans Immunology Immunophenotyping Interleukin-7 - genetics Interleukin-7 - immunology Interleukins Laboratories Life Sciences Life span Lymphocyte Activation Lymphocytes Lymphocytes T Male Mathematics Medicine and Health Sciences Middle Aged Molecular biology NF-kappa B - genetics NF-kappa B - immunology NF-κB protein People and Places Peptides Phosphorylation Physics Platelet Endothelial Cell Adhesion Molecule-1 - genetics Platelet Endothelial Cell Adhesion Molecule-1 - immunology Population Research and Analysis Methods Rheumatoid arthritis Signal Transduction Signaling Supervision T cells Thymic involution Thymus Thymus Gland - cytology Thymus Gland - growth & development Thymus Gland - immunology
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