A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host
Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical...
Gespeichert in:
| Veröffentlicht in: | PLoS biology 2019-10, Vol.17 (10), p.e3000485 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | e3000485 |
| container_title | PLoS biology |
| container_volume | 17 |
| creator | Gao, Jiarong Yang, Ning Lewis, Fred A Yau, Peter Collins, 3rd, James J Sweedler, Jonathan V Newmark, Phillip A |
| description | Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection. |
| doi_str_mv | 10.1371/journal.pbio.3000485 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2314604471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A607647057</galeid><doaj_id>oai_doaj_org_article_d562f634e428434e90cb5ac4de6f9c80</doaj_id><sourcerecordid>A607647057</sourcerecordid><originalsourceid>FETCH-LOGICAL-c695t-85adcf1f8cd1117f85912e748eb733af0be8606c6b4ddd5e891ce7d47a6595ea3</originalsourceid><addsrcrecordid>eNqVkl2LEzEUhgdR3LX6D0QHvNqLqcnkc26EsrhaWFzw6zacyUebMjOpybS4_97Uzi5bUFBykXDOc96cvDlF8RKjOSYCv92EXRygm29bH-YEIUQle1ScY0ZZJaRkjx-cz4pnKW0Qquumlk-LM4J5XRPCzgtYlDGM3tlYGRv93ppyCxG629HrUod-G3ZDDkW7t8OYyjHCkHqfkg9DGVyZ9NqnMaTQe0g-50MJZQ99D52HoVyHND4vnjjokn0x7bPi29X7r5cfq-ubD8vLxXWlecPGSjIw2mEntcEYCydZg2srqLStIAQcaq3kiGveUmMMs7LB2gpDBXDWMAtkVrw-6m67kNTkTlI1wZQjSgXOxPJImAAbtY2-h3irAnj1OxDiSkHM7-6sMozXjhNqaS1p3hqkWwaaGstdoyXKWu-m23Ztb43O7mTXTkRPM4Nfq1XYKy4acfB-VryZBGL4sbNp_EvLE7WC3JUfXMhiOn-AVguOBKcCMZGp-R-ovIztvQ6DdT7HTwouTgoyM9qf4wp2Kanll8__wX76d_bm-ylLj6yOIaVo3b15GKnDhN8Zog4TrqYJz2WvHhp_X3Q30uQXq5z4NA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2314604471</pqid></control><display><type>article</type><title>A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Gao, Jiarong ; Yang, Ning ; Lewis, Fred A ; Yau, Peter ; Collins, 3rd, James J ; Sweedler, Jonathan V ; Newmark, Phillip A</creator><contributor>Khosla, Chaitan</contributor><creatorcontrib>Gao, Jiarong ; Yang, Ning ; Lewis, Fred A ; Yau, Peter ; Collins, 3rd, James J ; Sweedler, Jonathan V ; Newmark, Phillip A ; Khosla, Chaitan</creatorcontrib><description>Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection.</description><identifier>ISSN: 1545-7885</identifier><identifier>ISSN: 1544-9173</identifier><identifier>EISSN: 1545-7885</identifier><identifier>DOI: 10.1371/journal.pbio.3000485</identifier><identifier>PMID: 31622335</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alkaloids - chemistry ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Animals ; Anthelmintics - chemistry ; Anthelmintics - isolation & purification ; Anthelmintics - pharmacology ; Biology and Life Sciences ; Cercaria - drug effects ; Cercaria - pathogenicity ; Cercaria - physiology ; Developmental biology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Flatworms ; Health aspects ; Infections ; Life cycles ; Liver - drug effects ; Liver - parasitology ; Male ; Mammals ; Mass spectrometry ; Medicine and Health Sciences ; Mice ; Microscopy ; Motility ; Movement - drug effects ; Movement - physiology ; Organic chemistry ; Paralysis ; Parasites ; Physical Sciences ; Praziquantel ; Proteins ; Purification ; Research and analysis methods ; Rotifera - chemistry ; Rotifera - isolation & purification ; Rotifera - metabolism ; Schistosoma mansoni - drug effects ; Schistosoma mansoni - growth & development ; Schistosoma mansoni - pathogenicity ; Schistosomiasis ; Schistosomiasis - parasitology ; Schistosomiasis - prevention & control ; Schistosomiasis - transmission ; Scientific imaging ; Serotonin ; Short Reports ; Skin - drug effects ; Skin - parasitology ; Snails - parasitology ; Solubility ; Structure-Activity Relationship ; Tropical diseases</subject><ispartof>PLoS biology, 2019-10, Vol.17 (10), p.e3000485</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Gao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Gao et al 2019 Gao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c695t-85adcf1f8cd1117f85912e748eb733af0be8606c6b4ddd5e891ce7d47a6595ea3</citedby><cites>FETCH-LOGICAL-c695t-85adcf1f8cd1117f85912e748eb733af0be8606c6b4ddd5e891ce7d47a6595ea3</cites><orcidid>0000-0003-0793-022X ; 0000-0002-1984-185X ; 0000-0003-3107-9922 ; 0000-0003-3447-5816</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797223/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797223/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31622335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Khosla, Chaitan</contributor><creatorcontrib>Gao, Jiarong</creatorcontrib><creatorcontrib>Yang, Ning</creatorcontrib><creatorcontrib>Lewis, Fred A</creatorcontrib><creatorcontrib>Yau, Peter</creatorcontrib><creatorcontrib>Collins, 3rd, James J</creatorcontrib><creatorcontrib>Sweedler, Jonathan V</creatorcontrib><creatorcontrib>Newmark, Phillip A</creatorcontrib><title>A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host</title><title>PLoS biology</title><addtitle>PLoS Biol</addtitle><description>Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection.</description><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Anthelmintics - chemistry</subject><subject>Anthelmintics - isolation & purification</subject><subject>Anthelmintics - pharmacology</subject><subject>Biology and Life Sciences</subject><subject>Cercaria - drug effects</subject><subject>Cercaria - pathogenicity</subject><subject>Cercaria - physiology</subject><subject>Developmental biology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Flatworms</subject><subject>Health aspects</subject><subject>Infections</subject><subject>Life cycles</subject><subject>Liver - drug effects</subject><subject>Liver - parasitology</subject><subject>Male</subject><subject>Mammals</subject><subject>Mass spectrometry</subject><subject>Medicine and Health Sciences</subject><subject>Mice</subject><subject>Microscopy</subject><subject>Motility</subject><subject>Movement - drug effects</subject><subject>Movement - physiology</subject><subject>Organic chemistry</subject><subject>Paralysis</subject><subject>Parasites</subject><subject>Physical Sciences</subject><subject>Praziquantel</subject><subject>Proteins</subject><subject>Purification</subject><subject>Research and analysis methods</subject><subject>Rotifera - chemistry</subject><subject>Rotifera - isolation & purification</subject><subject>Rotifera - metabolism</subject><subject>Schistosoma mansoni - drug effects</subject><subject>Schistosoma mansoni - growth & development</subject><subject>Schistosoma mansoni - pathogenicity</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis - parasitology</subject><subject>Schistosomiasis - prevention & control</subject><subject>Schistosomiasis - transmission</subject><subject>Scientific imaging</subject><subject>Serotonin</subject><subject>Short Reports</subject><subject>Skin - drug effects</subject><subject>Skin - parasitology</subject><subject>Snails - parasitology</subject><subject>Solubility</subject><subject>Structure-Activity Relationship</subject><subject>Tropical diseases</subject><issn>1545-7885</issn><issn>1544-9173</issn><issn>1545-7885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqVkl2LEzEUhgdR3LX6D0QHvNqLqcnkc26EsrhaWFzw6zacyUebMjOpybS4_97Uzi5bUFBykXDOc96cvDlF8RKjOSYCv92EXRygm29bH-YEIUQle1ScY0ZZJaRkjx-cz4pnKW0Qquumlk-LM4J5XRPCzgtYlDGM3tlYGRv93ppyCxG629HrUod-G3ZDDkW7t8OYyjHCkHqfkg9DGVyZ9NqnMaTQe0g-50MJZQ99D52HoVyHND4vnjjokn0x7bPi29X7r5cfq-ubD8vLxXWlecPGSjIw2mEntcEYCydZg2srqLStIAQcaq3kiGveUmMMs7LB2gpDBXDWMAtkVrw-6m67kNTkTlI1wZQjSgXOxPJImAAbtY2-h3irAnj1OxDiSkHM7-6sMozXjhNqaS1p3hqkWwaaGstdoyXKWu-m23Ztb43O7mTXTkRPM4Nfq1XYKy4acfB-VryZBGL4sbNp_EvLE7WC3JUfXMhiOn-AVguOBKcCMZGp-R-ovIztvQ6DdT7HTwouTgoyM9qf4wp2Kanll8__wX76d_bm-ylLj6yOIaVo3b15GKnDhN8Zog4TrqYJz2WvHhp_X3Q30uQXq5z4NA</recordid><startdate>20191017</startdate><enddate>20191017</enddate><creator>Gao, Jiarong</creator><creator>Yang, Ning</creator><creator>Lewis, Fred A</creator><creator>Yau, Peter</creator><creator>Collins, 3rd, James J</creator><creator>Sweedler, Jonathan V</creator><creator>Newmark, Phillip A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><scope>CZG</scope><orcidid>https://orcid.org/0000-0003-0793-022X</orcidid><orcidid>https://orcid.org/0000-0002-1984-185X</orcidid><orcidid>https://orcid.org/0000-0003-3107-9922</orcidid><orcidid>https://orcid.org/0000-0003-3447-5816</orcidid></search><sort><creationdate>20191017</creationdate><title>A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host</title><author>Gao, Jiarong ; Yang, Ning ; Lewis, Fred A ; Yau, Peter ; Collins, 3rd, James J ; Sweedler, Jonathan V ; Newmark, Phillip A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c695t-85adcf1f8cd1117f85912e748eb733af0be8606c6b4ddd5e891ce7d47a6595ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alkaloids - chemistry</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>Anthelmintics - chemistry</topic><topic>Anthelmintics - isolation & purification</topic><topic>Anthelmintics - pharmacology</topic><topic>Biology and Life Sciences</topic><topic>Cercaria - drug effects</topic><topic>Cercaria - pathogenicity</topic><topic>Cercaria - physiology</topic><topic>Developmental biology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Flatworms</topic><topic>Health aspects</topic><topic>Infections</topic><topic>Life cycles</topic><topic>Liver - drug effects</topic><topic>Liver - parasitology</topic><topic>Male</topic><topic>Mammals</topic><topic>Mass spectrometry</topic><topic>Medicine and Health Sciences</topic><topic>Mice</topic><topic>Microscopy</topic><topic>Motility</topic><topic>Movement - drug effects</topic><topic>Movement - physiology</topic><topic>Organic chemistry</topic><topic>Paralysis</topic><topic>Parasites</topic><topic>Physical Sciences</topic><topic>Praziquantel</topic><topic>Proteins</topic><topic>Purification</topic><topic>Research and analysis methods</topic><topic>Rotifera - chemistry</topic><topic>Rotifera - isolation & purification</topic><topic>Rotifera - metabolism</topic><topic>Schistosoma mansoni - drug effects</topic><topic>Schistosoma mansoni - growth & development</topic><topic>Schistosoma mansoni - pathogenicity</topic><topic>Schistosomiasis</topic><topic>Schistosomiasis - parasitology</topic><topic>Schistosomiasis - prevention & control</topic><topic>Schistosomiasis - transmission</topic><topic>Scientific imaging</topic><topic>Serotonin</topic><topic>Short Reports</topic><topic>Skin - drug effects</topic><topic>Skin - parasitology</topic><topic>Snails - parasitology</topic><topic>Solubility</topic><topic>Structure-Activity Relationship</topic><topic>Tropical diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Jiarong</creatorcontrib><creatorcontrib>Yang, Ning</creatorcontrib><creatorcontrib>Lewis, Fred A</creatorcontrib><creatorcontrib>Yau, Peter</creatorcontrib><creatorcontrib>Collins, 3rd, James J</creatorcontrib><creatorcontrib>Sweedler, Jonathan V</creatorcontrib><creatorcontrib>Newmark, Phillip A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>PLoS Biology</collection><jtitle>PLoS biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Jiarong</au><au>Yang, Ning</au><au>Lewis, Fred A</au><au>Yau, Peter</au><au>Collins, 3rd, James J</au><au>Sweedler, Jonathan V</au><au>Newmark, Phillip A</au><au>Khosla, Chaitan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host</atitle><jtitle>PLoS biology</jtitle><addtitle>PLoS Biol</addtitle><date>2019-10-17</date><risdate>2019</risdate><volume>17</volume><issue>10</issue><spage>e3000485</spage><pages>e3000485-</pages><issn>1545-7885</issn><issn>1544-9173</issn><eissn>1545-7885</eissn><abstract>Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and the emergence of schistosomiasis in nontropical areas indicate the need for new strategies to prevent infection. It has been known for several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor that paralyzes cercariae, the life cycle stage infecting humans. In spite of its potential for preventing infection, the nature of this factor has remained obscure. Here, we report the purification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic alkaloid produced by the rotifer Rotaria rotatoria. We show that this compound paralyzes schistosome cercariae and prevents infection and does so more effectively than analogous compounds. This molecule provides new directions for understanding cercariae motility and new strategies for preventing schistosome infection.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31622335</pmid><doi>10.1371/journal.pbio.3000485</doi><orcidid>https://orcid.org/0000-0003-0793-022X</orcidid><orcidid>https://orcid.org/0000-0002-1984-185X</orcidid><orcidid>https://orcid.org/0000-0003-3107-9922</orcidid><orcidid>https://orcid.org/0000-0003-3447-5816</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1545-7885 |
| ispartof | PLoS biology, 2019-10, Vol.17 (10), p.e3000485 |
| issn | 1545-7885 1544-9173 1545-7885 |
| language | eng |
| recordid | cdi_plos_journals_2314604471 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Anthelmintics - chemistry Anthelmintics - isolation & purification Anthelmintics - pharmacology Biology and Life Sciences Cercaria - drug effects Cercaria - pathogenicity Cercaria - physiology Developmental biology Disease Models, Animal Dose-Response Relationship, Drug Female Flatworms Health aspects Infections Life cycles Liver - drug effects Liver - parasitology Male Mammals Mass spectrometry Medicine and Health Sciences Mice Microscopy Motility Movement - drug effects Movement - physiology Organic chemistry Paralysis Parasites Physical Sciences Praziquantel Proteins Purification Research and analysis methods Rotifera - chemistry Rotifera - isolation & purification Rotifera - metabolism Schistosoma mansoni - drug effects Schistosoma mansoni - growth & development Schistosoma mansoni - pathogenicity Schistosomiasis Schistosomiasis - parasitology Schistosomiasis - prevention & control Schistosomiasis - transmission Scientific imaging Serotonin Short Reports Skin - drug effects Skin - parasitology Snails - parasitology Solubility Structure-Activity Relationship Tropical diseases |
| title | A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T09%3A03%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20rotifer-derived%20paralytic%20compound%20prevents%20transmission%20of%20schistosomiasis%20to%20a%20mammalian%20host&rft.jtitle=PLoS%20biology&rft.au=Gao,%20Jiarong&rft.date=2019-10-17&rft.volume=17&rft.issue=10&rft.spage=e3000485&rft.pages=e3000485-&rft.issn=1545-7885&rft.eissn=1545-7885&rft_id=info:doi/10.1371/journal.pbio.3000485&rft_dat=%3Cgale_plos_%3EA607647057%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2314604471&rft_id=info:pmid/31622335&rft_galeid=A607647057&rft_doaj_id=oai_doaj_org_article_d562f634e428434e90cb5ac4de6f9c80&rfr_iscdi=true |