Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction

Reversal reactions (RRs) in leprosy are characterized by a reduction in the number of bacilli in lesions associated with an increase in cell-mediated immunity against the intracellular bacterium Mycobacterium leprae, the causative pathogen of leprosy. To identify the mechanisms that contribute to ce...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-10, Vol.13 (10), p.e0007764
Hauptverfasser:	Teles, Rosane M B, Lu, Jing, Tió-Coma, Maria, Goulart, Isabela M B, Banu, Sayera, Hagge, Deanna, Bobosha, Kidist, Ottenhoff, Tom H M, Pellegrini, Matteo, Geluk, Annemieke, Modlin, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antimicrobial agents Bacilli Bacterial infections Biology and Life Sciences Blood Cell-mediated immunity Chromosome Mapping Correlation analysis Cytokines Dermatology Developmental biology Geffen, David Gene expression Gene Expression - drug effects Gene Expression Profiling Genes GTP-Binding Proteins - genetics Humans Immunity Immunity, Cellular Infectious diseases Interferon Interferon-beta Interferon-gamma - immunology Laboratories Leprosy Leprosy - immunology Leprosy - metabolism Lesions Medicine Medicine and Health Sciences Modules Mycobacterium leprae - immunology Network analysis Pathogens Peripheral blood Proteins RNA, Messenger Transcriptome Tropical diseases Tuberculosis Up-Regulation β-Interferon γ-Interferon
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