Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells

Calreticulin (CRT) and vascular endothelial growth factor-A (VEGF-A) are crucial for angiogenesis, and mediate multiple malignant behaviors in gastric cancer. In this study, we report that CRT is positively correlated with VEGF-A in gastric cancer patients. Moreover, high expressions of both CRT and...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0225107-e0225107
Hauptverfasser:	Lee, Po-Chu, Chiang, Jui-Chung, Chen, Chih-Yu, Chien, Yin-Chieh, Chen, Wei-Min, Huang, Chin-Wei, Weng, Wen-Chin, Chen, Chia-I, Lee, Po-Huang, Chen, Chiung-Nien, Lee, Hsinyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Angiotensin II Biology and life sciences Biomarkers, Tumor Bladder cancer Brain cancer Calreticulin Calreticulin - metabolism Cancer Cancer cells Cancer research Cell Line, Tumor Cell proliferation EDTA Electrophoretic mobility Endoplasmic reticulum Endothelial cells Endothelial growth factors Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Growth factors Humans Hypoxia Insurance claims Luciferase Lymphatic system Maintenance Male Medicine and Health Sciences Messenger RNA Metastasis Middle Aged mRNA stability Neoplasm Metastasis Neoplasm Staging Novels Nucleotide sequence Pancreatic cancer Pediatrics Prognosis Protein Binding Proteins Recombinant proteins Research and Analysis Methods RNA RNA Stability RNA, Messenger - genetics Scientific equipment industry Stability Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Surgery Tumor cell lines Umbilical vein Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics
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