Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study
Preterm birth has previously been linked with cardiovascular disease (CVD) in adulthood. However, associations with lipid disorders (e.g., high cholesterol or triglycerides), which are major risk factors for CVD, have seldom been examined and are conflicting. Clinicians will increasingly encounter a...
Gespeichert in:
| Veröffentlicht in: | PLoS medicine 2019-10, Vol.16 (10), p.e1002947 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | e1002947 |
| container_title | PLoS medicine |
| container_volume | 16 |
| creator | Crump, Casey Sundquist, Jan Sundquist, Kristina |
| description | Preterm birth has previously been linked with cardiovascular disease (CVD) in adulthood. However, associations with lipid disorders (e.g., high cholesterol or triglycerides), which are major risk factors for CVD, have seldom been examined and are conflicting. Clinicians will increasingly encounter adult survivors of preterm birth and will need to understand the long-term health sequelae. We conducted the first large population-based study to determine whether preterm birth is associated with an increased risk of lipid disorders.
A retrospective national cohort study was conducted of all 2,235,012 persons born as singletons in Sweden during 1973 to 1995 (48.6% women), who were followed up for lipid disorders identified from nationwide inpatient, outpatient, and pharmacy data through 2016 (maximum age 44 years). Cox regression was used to adjust for other perinatal and maternal factors, and co-sibling analyses assessed the potential influence of unmeasured shared familial (genetic and/or environmental) factors. A total of 25,050 (1.1%) persons were identified with lipid disorders in 30.3 million person-years of follow-up. Each additional 5 weeks of gestation were associated with a 14% reduction in risk of lipid disorders (adjusted hazard ratio [HR], 0.86; 95% CI, 0.83-0.89; P < 0.001). Relative to full-term birth (gestational age 39-41 weeks), the adjusted HR associated with preterm birth ( |
| doi_str_mv | 10.1371/journal.pmed.1002947 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2314540883</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A607647052</galeid><doaj_id>oai_doaj_org_article_2a7c294865cc46e4ae98f3f32ea8e433</doaj_id><sourcerecordid>A607647052</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6797-b36b666d0617ce8ba7ff4b376164494457942c45d7ac1a9007f6c129dd9fce333</originalsourceid><addsrcrecordid>eNqVk-uK1DAUx4so7kXfQDQgLPhhxqRNk2Y_CMPiZWBxwVU_GtLkdJqh04xJ6zpv47P4ZGZ2ussURlACSUh-53-Sc0mSZwRPScbJ66Xrfaua6XoFZkowTgXlD5JjklMxIYyzh3v7o-QkhOWWwQI_To4ywlLG8vQ4-TYLwWmrOuta5Cq09tCBX6HS-q5GNzZOjV1bg4wNzhvwAdkWgfLNBinTN13tnDlHv3_N0PUNRKhG2tXOdyh0vdk8SR5VqgnwdFhPky_v3n6--DC5vHo_v5hdTjTjgk_KjJWMMYMZ4RqKUvGqomXGGWGUCkpzLmiqaW640kQJjHnFNEmFMaLSkGXZafJip7tuXJBDaIJMM0JziotiS8x3hHFqKdferpTfSKesvD1wfiGV76xuQKaK6xjNguVaUwZUgSiqrMpSUAXQW29vBm99GaOvoe28akai45vW1nLhfsj4WVEUeRR4OQh4972H0P3lyQO1UPFVtq1cFNMrG7ScMcwZ5ThPIzU5QC2ghejZtVDZeDzipwf4OAysrD5o8GpkEJkOfnYL1Ycg59ef_oP9-O_s1dcxe7bH1qBi4QXX9NuyDWOQ7kDtXQgeqvusECy3fXMXabntGzn0TTR7vp_Re6O7Rsn-AGTDEd4</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2314540883</pqid></control><display><type>article</type><title>Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><creator>Crump, Casey ; Sundquist, Jan ; Sundquist, Kristina</creator><contributor>Smith, Gordon C.</contributor><creatorcontrib>Crump, Casey ; Sundquist, Jan ; Sundquist, Kristina ; Smith, Gordon C.</creatorcontrib><description><![CDATA[Preterm birth has previously been linked with cardiovascular disease (CVD) in adulthood. However, associations with lipid disorders (e.g., high cholesterol or triglycerides), which are major risk factors for CVD, have seldom been examined and are conflicting. Clinicians will increasingly encounter adult survivors of preterm birth and will need to understand the long-term health sequelae. We conducted the first large population-based study to determine whether preterm birth is associated with an increased risk of lipid disorders.
A retrospective national cohort study was conducted of all 2,235,012 persons born as singletons in Sweden during 1973 to 1995 (48.6% women), who were followed up for lipid disorders identified from nationwide inpatient, outpatient, and pharmacy data through 2016 (maximum age 44 years). Cox regression was used to adjust for other perinatal and maternal factors, and co-sibling analyses assessed the potential influence of unmeasured shared familial (genetic and/or environmental) factors. A total of 25,050 (1.1%) persons were identified with lipid disorders in 30.3 million person-years of follow-up. Each additional 5 weeks of gestation were associated with a 14% reduction in risk of lipid disorders (adjusted hazard ratio [HR], 0.86; 95% CI, 0.83-0.89; P < 0.001). Relative to full-term birth (gestational age 39-41 weeks), the adjusted HR associated with preterm birth (<37 weeks) was 1.23 (95% CI, 1.16-1.29; P < 0.001), and further stratified was 2.00 (1.41-2.85; P < 0.001) for extremely preterm (22-27 weeks), 1.33 (1.19-1.49; P < 0.001) for very preterm (28-33 weeks), and 1.19 (1.12-1.26; P < 0.001) for late preterm (34-36 weeks). These findings were similar in men and women (e.g., preterm versus full-term, men: HR, 1.22; 95% CI, 1.14-1.31; P < 0.001; women: HR, 1.23; 1.12-1.32; P < 0.001). Co-sibling analyses suggested that they were substantially though not completely explained by shared genetic or environmental factors in families. The main study limitation was the unavailability of laboratory data to assess specific types or severity of lipid disorders.
In this large national cohort, preterm birth was associated with an increased risk of lipid disorders in early- to midadulthood. Persons born prematurely may need early preventive evaluation and long-term monitoring for lipid disorders to reduce their future cardiovascular risks.]]></description><identifier>ISSN: 1549-1676</identifier><identifier>ISSN: 1549-1277</identifier><identifier>EISSN: 1549-1676</identifier><identifier>DOI: 10.1371/journal.pmed.1002947</identifier><identifier>PMID: 31626652</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Analysis ; Biology and Life Sciences ; Birth ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cholesterol ; Cholesterol - blood ; Cohort analysis ; Complications ; Disorders ; Drugstores ; Dyslipidemias - epidemiology ; Environmental factors ; Family medical history ; Female ; Follow-Up Studies ; Funding ; Genetic research ; Gestation ; Gestational Age ; Health ; Health risk assessment ; Health risks ; Hospitals ; Humans ; Lipids ; Male ; Medicine and Health Sciences ; Mortality ; Mutation ; People and places ; Pharmacy ; Population ; Population studies ; Premature birth ; Premature Birth - epidemiology ; Premature infants ; Primary care ; Proportional Hazards Models ; Registries ; Retrospective Studies ; Risk Factors ; Siblings ; Studies ; Sweden - epidemiology ; Triglycerides ; Triglycerides - blood ; Young Adult ; Young adults</subject><ispartof>PLoS medicine, 2019-10, Vol.16 (10), p.e1002947</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Crump et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Crump et al 2019 Crump et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6797-b36b666d0617ce8ba7ff4b376164494457942c45d7ac1a9007f6c129dd9fce333</citedby><cites>FETCH-LOGICAL-c6797-b36b666d0617ce8ba7ff4b376164494457942c45d7ac1a9007f6c129dd9fce333</cites><orcidid>0000-0002-2990-1166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799885/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799885/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31626652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Smith, Gordon C.</contributor><creatorcontrib>Crump, Casey</creatorcontrib><creatorcontrib>Sundquist, Jan</creatorcontrib><creatorcontrib>Sundquist, Kristina</creatorcontrib><title>Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study</title><title>PLoS medicine</title><addtitle>PLoS Med</addtitle><description><![CDATA[Preterm birth has previously been linked with cardiovascular disease (CVD) in adulthood. However, associations with lipid disorders (e.g., high cholesterol or triglycerides), which are major risk factors for CVD, have seldom been examined and are conflicting. Clinicians will increasingly encounter adult survivors of preterm birth and will need to understand the long-term health sequelae. We conducted the first large population-based study to determine whether preterm birth is associated with an increased risk of lipid disorders.
A retrospective national cohort study was conducted of all 2,235,012 persons born as singletons in Sweden during 1973 to 1995 (48.6% women), who were followed up for lipid disorders identified from nationwide inpatient, outpatient, and pharmacy data through 2016 (maximum age 44 years). Cox regression was used to adjust for other perinatal and maternal factors, and co-sibling analyses assessed the potential influence of unmeasured shared familial (genetic and/or environmental) factors. A total of 25,050 (1.1%) persons were identified with lipid disorders in 30.3 million person-years of follow-up. Each additional 5 weeks of gestation were associated with a 14% reduction in risk of lipid disorders (adjusted hazard ratio [HR], 0.86; 95% CI, 0.83-0.89; P < 0.001). Relative to full-term birth (gestational age 39-41 weeks), the adjusted HR associated with preterm birth (<37 weeks) was 1.23 (95% CI, 1.16-1.29; P < 0.001), and further stratified was 2.00 (1.41-2.85; P < 0.001) for extremely preterm (22-27 weeks), 1.33 (1.19-1.49; P < 0.001) for very preterm (28-33 weeks), and 1.19 (1.12-1.26; P < 0.001) for late preterm (34-36 weeks). These findings were similar in men and women (e.g., preterm versus full-term, men: HR, 1.22; 95% CI, 1.14-1.31; P < 0.001; women: HR, 1.23; 1.12-1.32; P < 0.001). Co-sibling analyses suggested that they were substantially though not completely explained by shared genetic or environmental factors in families. The main study limitation was the unavailability of laboratory data to assess specific types or severity of lipid disorders.
In this large national cohort, preterm birth was associated with an increased risk of lipid disorders in early- to midadulthood. Persons born prematurely may need early preventive evaluation and long-term monitoring for lipid disorders to reduce their future cardiovascular risks.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Birth</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cohort analysis</subject><subject>Complications</subject><subject>Disorders</subject><subject>Drugstores</subject><subject>Dyslipidemias - epidemiology</subject><subject>Environmental factors</subject><subject>Family medical history</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Funding</subject><subject>Genetic research</subject><subject>Gestation</subject><subject>Gestational Age</subject><subject>Health</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Mutation</subject><subject>People and places</subject><subject>Pharmacy</subject><subject>Population</subject><subject>Population studies</subject><subject>Premature birth</subject><subject>Premature Birth - epidemiology</subject><subject>Premature infants</subject><subject>Primary care</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Siblings</subject><subject>Studies</subject><subject>Sweden - epidemiology</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>1549-1676</issn><issn>1549-1277</issn><issn>1549-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqVk-uK1DAUx4so7kXfQDQgLPhhxqRNk2Y_CMPiZWBxwVU_GtLkdJqh04xJ6zpv47P4ZGZ2ussURlACSUh-53-Sc0mSZwRPScbJ66Xrfaua6XoFZkowTgXlD5JjklMxIYyzh3v7o-QkhOWWwQI_To4ywlLG8vQ4-TYLwWmrOuta5Cq09tCBX6HS-q5GNzZOjV1bg4wNzhvwAdkWgfLNBinTN13tnDlHv3_N0PUNRKhG2tXOdyh0vdk8SR5VqgnwdFhPky_v3n6--DC5vHo_v5hdTjTjgk_KjJWMMYMZ4RqKUvGqomXGGWGUCkpzLmiqaW640kQJjHnFNEmFMaLSkGXZafJip7tuXJBDaIJMM0JziotiS8x3hHFqKdferpTfSKesvD1wfiGV76xuQKaK6xjNguVaUwZUgSiqrMpSUAXQW29vBm99GaOvoe28akai45vW1nLhfsj4WVEUeRR4OQh4972H0P3lyQO1UPFVtq1cFNMrG7ScMcwZ5ThPIzU5QC2ghejZtVDZeDzipwf4OAysrD5o8GpkEJkOfnYL1Ycg59ef_oP9-O_s1dcxe7bH1qBi4QXX9NuyDWOQ7kDtXQgeqvusECy3fXMXabntGzn0TTR7vp_Re6O7Rsn-AGTDEd4</recordid><startdate>20191018</startdate><enddate>20191018</enddate><creator>Crump, Casey</creator><creator>Sundquist, Jan</creator><creator>Sundquist, Kristina</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><scope>CZK</scope><orcidid>https://orcid.org/0000-0002-2990-1166</orcidid></search><sort><creationdate>20191018</creationdate><title>Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study</title><author>Crump, Casey ; Sundquist, Jan ; Sundquist, Kristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6797-b36b666d0617ce8ba7ff4b376164494457942c45d7ac1a9007f6c129dd9fce333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Birth</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cohort analysis</topic><topic>Complications</topic><topic>Disorders</topic><topic>Drugstores</topic><topic>Dyslipidemias - epidemiology</topic><topic>Environmental factors</topic><topic>Family medical history</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Funding</topic><topic>Genetic research</topic><topic>Gestation</topic><topic>Gestational Age</topic><topic>Health</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Mutation</topic><topic>People and places</topic><topic>Pharmacy</topic><topic>Population</topic><topic>Population studies</topic><topic>Premature birth</topic><topic>Premature Birth - epidemiology</topic><topic>Premature infants</topic><topic>Primary care</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Siblings</topic><topic>Studies</topic><topic>Sweden - epidemiology</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crump, Casey</creatorcontrib><creatorcontrib>Sundquist, Jan</creatorcontrib><creatorcontrib>Sundquist, Kristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>PLoS Medicine</collection><jtitle>PLoS medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crump, Casey</au><au>Sundquist, Jan</au><au>Sundquist, Kristina</au><au>Smith, Gordon C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study</atitle><jtitle>PLoS medicine</jtitle><addtitle>PLoS Med</addtitle><date>2019-10-18</date><risdate>2019</risdate><volume>16</volume><issue>10</issue><spage>e1002947</spage><pages>e1002947-</pages><issn>1549-1676</issn><issn>1549-1277</issn><eissn>1549-1676</eissn><abstract><![CDATA[Preterm birth has previously been linked with cardiovascular disease (CVD) in adulthood. However, associations with lipid disorders (e.g., high cholesterol or triglycerides), which are major risk factors for CVD, have seldom been examined and are conflicting. Clinicians will increasingly encounter adult survivors of preterm birth and will need to understand the long-term health sequelae. We conducted the first large population-based study to determine whether preterm birth is associated with an increased risk of lipid disorders.
A retrospective national cohort study was conducted of all 2,235,012 persons born as singletons in Sweden during 1973 to 1995 (48.6% women), who were followed up for lipid disorders identified from nationwide inpatient, outpatient, and pharmacy data through 2016 (maximum age 44 years). Cox regression was used to adjust for other perinatal and maternal factors, and co-sibling analyses assessed the potential influence of unmeasured shared familial (genetic and/or environmental) factors. A total of 25,050 (1.1%) persons were identified with lipid disorders in 30.3 million person-years of follow-up. Each additional 5 weeks of gestation were associated with a 14% reduction in risk of lipid disorders (adjusted hazard ratio [HR], 0.86; 95% CI, 0.83-0.89; P < 0.001). Relative to full-term birth (gestational age 39-41 weeks), the adjusted HR associated with preterm birth (<37 weeks) was 1.23 (95% CI, 1.16-1.29; P < 0.001), and further stratified was 2.00 (1.41-2.85; P < 0.001) for extremely preterm (22-27 weeks), 1.33 (1.19-1.49; P < 0.001) for very preterm (28-33 weeks), and 1.19 (1.12-1.26; P < 0.001) for late preterm (34-36 weeks). These findings were similar in men and women (e.g., preterm versus full-term, men: HR, 1.22; 95% CI, 1.14-1.31; P < 0.001; women: HR, 1.23; 1.12-1.32; P < 0.001). Co-sibling analyses suggested that they were substantially though not completely explained by shared genetic or environmental factors in families. The main study limitation was the unavailability of laboratory data to assess specific types or severity of lipid disorders.
In this large national cohort, preterm birth was associated with an increased risk of lipid disorders in early- to midadulthood. Persons born prematurely may need early preventive evaluation and long-term monitoring for lipid disorders to reduce their future cardiovascular risks.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31626652</pmid><doi>10.1371/journal.pmed.1002947</doi><orcidid>https://orcid.org/0000-0002-2990-1166</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1549-1676 |
| ispartof | PLoS medicine, 2019-10, Vol.16 (10), p.e1002947 |
| issn | 1549-1676 1549-1277 1549-1676 |
| language | eng |
| recordid | cdi_plos_journals_2314540883 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central |
| subjects | Adolescent Adult Adults Age Analysis Biology and Life Sciences Birth Cardiovascular diseases Cardiovascular Diseases - epidemiology Cholesterol Cholesterol - blood Cohort analysis Complications Disorders Drugstores Dyslipidemias - epidemiology Environmental factors Family medical history Female Follow-Up Studies Funding Genetic research Gestation Gestational Age Health Health risk assessment Health risks Hospitals Humans Lipids Male Medicine and Health Sciences Mortality Mutation People and places Pharmacy Population Population studies Premature birth Premature Birth - epidemiology Premature infants Primary care Proportional Hazards Models Registries Retrospective Studies Risk Factors Siblings Studies Sweden - epidemiology Triglycerides Triglycerides - blood Young Adult Young adults |
| title | Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T22%3A24%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20preterm%20birth%20with%20lipid%20disorders%20in%20early%20adulthood:%20%C2%A0A%20Swedish%20cohort%20study&rft.jtitle=PLoS%20medicine&rft.au=Crump,%20Casey&rft.date=2019-10-18&rft.volume=16&rft.issue=10&rft.spage=e1002947&rft.pages=e1002947-&rft.issn=1549-1676&rft.eissn=1549-1676&rft_id=info:doi/10.1371/journal.pmed.1002947&rft_dat=%3Cgale_plos_%3EA607647052%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2314540883&rft_id=info:pmid/31626652&rft_galeid=A607647052&rft_doaj_id=oai_doaj_org_article_2a7c294865cc46e4ae98f3f32ea8e433&rfr_iscdi=true |