Intranasal sufentanil versus intravenous morphine for acute severe trauma pain: A double-blind randomized non-inferiority study

Intravenous morphine (IVM) is the most common strong analgesic used in trauma, but is associated with a clear time limitation related to the need to obtain an access route. The intranasal (IN) route provides easy administration with a fast peak action time due to high vascularization and the absence...

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Veröffentlicht in:	PLoS medicine 2019-07, Vol.16 (7), p.e1002849-e1002849
Hauptverfasser:	Blancher, Marc, Maignan, Maxime, Clapé, Cyrielle, Quesada, Jean-Louis, Collomb-Muret, Roselyne, Albasini, François, Ageron, François-Xavier, Fey, Stephanie, Wuyts, Audrey, Banihachemi, Jean-Jacques, Bertrand, Barthelemy, Lehmann, Audrey, Bollart, Claire, Debaty, Guillaume, Briot, Raphaël, Viglino, Damien
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute pain Acute Pain - diagnosis Acute Pain - drug therapy Acute Pain - etiology Administration, Intranasal Administration, Intravenous Adult Aerosols Analgesia Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Anesthesia Anoxemia Bone surgery Clinical trials Comparative analysis Computer and Information Sciences Dosage and administration Double-Blind Method Double-blind studies Drug therapy Emergency medical services Emergency Service, Hospital Female France Funding Humans Hypoxemia Intensive care Intravenous administration Laboratories Life Sciences Male Medical research Medication Medicine and Health Sciences Metabolism Middle Aged Morphine Morphine - administration & dosage Morphine - adverse effects Narcotics Other Pain Pain management Pain Management - adverse effects Pain Management - methods Pain perception Patient outcomes Patients Pediatrics Pharmaceutical sciences Physicians Prospective Studies Randomization Research and Analysis Methods Severity of Illness Index Sufentanil Sufentanil - administration & dosage Sufentanil - adverse effects Time Factors Titration Trauma Treatment Outcome Vascularization Wounds and Injuries - complications Wounds and Injuries - diagnosis
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