Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment

Classic Hodgkin lymphoma (CHL) characteristically shows few malignant cells in a microenvironment comprised of mixed inflammatory cells. Although CHL is associated with a high cure rate, recent studies have associated poor prognosis with absolute monocyte count in peripheral blood and increased mono...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0224621-e0224621
Hauptverfasser:	Post, Ginell R, Yuan, Youzhong, Holthoff, Emily R, Quick, Charles M, Post, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism B-cell lymphoma Biology and Life Sciences Biomarkers CD14 antigen CD163 antigen Cloning Development and progression Ethylenediaminetetraacetic acid Gene expression Genetic aspects Glycoproteins Health aspects Hodgkin Disease - metabolism Hodgkin Disease - pathology Hodgkin's disease Hodgkin's lymphoma Humans Immunoglobulins Immunohistochemistry Inflammation Kinases Leukocytes (mononuclear) Liver Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Lymphoma Macrophages Macrophages - metabolism Macrophages - pathology Medical research Medicine and Health Sciences Medicine, Experimental Metastases Metastasis Monocytes Monocytes - metabolism Monocytes - pathology mRNA Nodes Non-Hodgkin's lymphomas Pathology Peripheral blood Phagocytes Phenotype Phenotypes Polymerase chain reaction Prognosis Proteins Research and Analysis Methods Retrospective Studies RNA Scavenger receptors Sclerosis Signal transduction Spleen Tumor Microenvironment - physiology Tumors
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