Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

Autophagy is an essential process involved in the pathogenesis of inflammatory bowel disease (IBD). Although there are many data showing the roles of autophagy in intestinal epithelial cells (IECs), the mechanisms involved remain to be fully elucidated. We investigated the influence of autophagy in...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0225066-e0225066
Hauptverfasser:	Kubota, Minori, Kakimoto, Kazuki, Nakagawa, Takatoshi, Koubayashi, Eiko, Nakazawa, Kei, Tawa, Hideki, Hirata, Yuki, Okada, Toshihiko, Kawakami, Ken, Asai, Akira, Hosomi, Shuhei, Takeuchi, Toshihisa, Fukunishi, Shinya, Inoue, Takuya, Asahi, Michio, Higuchi, Kazuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Animals Apoptosis Apoptosis - genetics Autophagy Autophagy-Related Protein 5 - genetics Biology and Life Sciences Biotechnology industries Cell death Cell Line Cell Survival - genetics Cell viability Colitis Colitis - metabolism Cytokines Cytokines - metabolism Dextran Dextran sulfate Dextrans Disease Models, Animal Drinking water Epithelial cells Flox Gastrointestinal diseases Gastrointestinal system Gastrointestinal tract Gene Knockdown Techniques Genomes Homeostasis Inflammation Inflammation Mediators - metabolism Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - etiology Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Internal medicine Intestine Intracellular signalling Kinases Laboratory animals Maintenance MAP kinase MAP Kinase Signaling System Medical schools Medicine Medicine and Health Sciences Mice Mice, Knockout Mitogens NF-kappa B - metabolism NF-κB protein Oxidative Stress Oxygen Pathogenesis Phagocytosis Phosphorylation Polysaccharides Protein kinase Protein kinases Reactive oxygen species Reactive Oxygen Species - metabolism Research and Analysis Methods Signal transduction Signaling Small intestine Sodium Sulfates TNF inhibitors Tumor necrosis factor-TNF
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