Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening

We investigated a potential use of a 3D tetraculture brain microphysiological system (BMPS) for neurotoxic chemical agent screening. This platform consists of neuronal tissue with extracellular matrix (ECM)-embedded neuroblastoma cells, microglia, and astrocytes, and vascular tissue with dynamic flo...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0224657
Hauptverfasser:	Liu, Lumei, Koo, Youngmi, Akwitti, Chukwuma, Russell, Teal, Gay, Elaine, Laskowitz, Daniel T, Yun, Yeoheung
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Animal models Animals Apoptosis Astrocytes Biocompatibility Biology and Life Sciences Blood-brain barrier Brain Brain - drug effects Brain - physiology Brain research Cell culture Cell Line Cell Survival - drug effects Chemical weapons Chlorpyrifos Computer simulation Dextromethorphan Endothelium Engineering Ethanol Extracellular matrix Flow (Dynamics) GABA Imaging, Three-Dimensional Laboratories Malathion Medicine and Health Sciences Membranes Mice Microfluidics Microglia Movement disorders Muscimol Narcotics Neuroblastoma Neuroblastoma cells Neuroblasts Neurons Neurosciences Neurotoxicity Neurotoxins - pharmacokinetics Neurotoxins - toxicity Opioid receptors Organic chemistry Organophosphates Organophosphates - pharmacokinetics Organophosphates - toxicity Parathion Pesticides Pharmacodynamics Pharmacokinetics Pharmacology Receptors, GABA - metabolism Receptors, Opioid - metabolism Screening Stem cells Time Factors Toxicity Toxicity Tests Toxicology Vascular tissue Viability γ-Aminobutyric acid
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