A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction

There is a reciprocal relationship between the circadian and the reward systems. Polymorphisms in several circadian rhythm-related (clock) genes were associated with drug addiction. This study aims to search for associations between 895 variants in 39 circadian rhythm-related genes and opioid addict...

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Veröffentlicht in:	PloS one 2019-11, Vol.14 (11), p.e0224399
Hauptverfasser:	Levran, Orna, Randesi, Matthew, Rotrosen, John, Ott, Jurg, Adelson, Miriam, Kreek, Mary Jeanne
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 3' Untranslated Regions - genetics Addiction Addictions Adelson, Sheldon Alcohol Analysis Autism Basic Helix-Loop-Helix Transcription Factors - genetics Biology Biology and Life Sciences Casein Casein kinase I Chromosomes Circadian rhythm Circadian Rhythm - genetics Circadian rhythms Cocaine Coding Drug abuse Drug addiction Gene expression Gene mapping Genes Genetic aspects Genetic diversity Genetic polymorphisms Genetic Predisposition to Disease Genetic research Genetic variance Genomes Genotypes Genotyping Heroin Humans Intestine Kinases Laboratories Medicine and Health Sciences Milk proteins Narcotics Neuropeptide Y Neuropeptides Non-coding RNA Nucleotides Opioid abuse Opioid-Related Disorders - genetics Opioids Peptides Period 2 protein Period Circadian Proteins - genetics Physiological aspects Polymorphism, Single Nucleotide Proteins Quantitative trait loci Quantitative Trait Loci - genetics Receptors, Vasoactive Intestinal Peptide, Type II - genetics Reinforcement Repressor Proteins - genetics Reward Ribonucleic acid RNA RNA, Long Noncoding - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Social Sciences Stress response Studies Substance abuse treatment Suprachiasmatic nucleus Transcription Vasoactive agents Vasoactive intestinal peptide Vasoactive intestinal peptides
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