Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat
While substantial task-related neural activity has been observed during motor tasks in rodent primary motor cortex and premotor cortex, the long-term stability of these responses in healthy rats is uncertain, limiting the interpretability of longitudinal changes in the specific patterns of neural ac...
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| description | While substantial task-related neural activity has been observed during motor tasks in rodent primary motor cortex and premotor cortex, the long-term stability of these responses in healthy rats is uncertain, limiting the interpretability of longitudinal changes in the specific patterns of neural activity associated with learning or motor recovery following injury. This study examined the stability of task-related neural activity associated with execution of two distinct reaching tasks in healthy rodents. A novel automated rodent behavioral apparatus was constructed and rats were trained to perform a reaching task combining a 'gross' lever press and a 'fine' pellet retrieval. In each animal, two chronic microelectrode arrays were implanted in motor cortex spanning the caudal forelimb area (rodent primary motor cortex) and the rostral forelimb area (rodent premotor cortex). We recorded multiunit spiking and local field potential activity from 10 days to 7-10 weeks post-implantation to characterize the patterns of neural activity observed during each task component and analyzed the consistency of channel-specific task-related neural activity. Task-related changes in neural activity were observed on the majority of channels. While the task-related changes in multi-unit spiking and local field potential spectral power were consistent over several weeks, spectral power changes were more stable, despite the trade-off of decreased spatial and temporal resolution. These results show that neural activity in rodent primary and premotor cortex is associated with specific phases of reaching movements with stable patterns of task-related activity across time, establishing the relevance of the rodent for future studies designed to examine changes in task-related neural activity during recovery from focal cortical lesions. |
| doi_str_mv | 10.1371/journal.pone.0219034 |
| format | Article |
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This study examined the stability of task-related neural activity associated with execution of two distinct reaching tasks in healthy rodents. A novel automated rodent behavioral apparatus was constructed and rats were trained to perform a reaching task combining a 'gross' lever press and a 'fine' pellet retrieval. In each animal, two chronic microelectrode arrays were implanted in motor cortex spanning the caudal forelimb area (rodent primary motor cortex) and the rostral forelimb area (rodent premotor cortex). We recorded multiunit spiking and local field potential activity from 10 days to 7-10 weeks post-implantation to characterize the patterns of neural activity observed during each task component and analyzed the consistency of channel-specific task-related neural activity. Task-related changes in neural activity were observed on the majority of channels. While the task-related changes in multi-unit spiking and local field potential spectral power were consistent over several weeks, spectral power changes were more stable, despite the trade-off of decreased spatial and temporal resolution. These results show that neural activity in rodent primary and premotor cortex is associated with specific phases of reaching movements with stable patterns of task-related activity across time, establishing the relevance of the rodent for future studies designed to examine changes in task-related neural activity during recovery from focal cortical lesions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0219034</identifier><identifier>PMID: 31665145</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Automation ; Behavior ; Biology and Life Sciences ; Brain ; Cortex (motor) ; Cortex (premotor) ; Cortex (temporal) ; Electrophysiological recording ; Engineering and Technology ; Forelimb - physiology ; Future predictions ; Implantation ; Laboratory rats ; Male ; Medicine and Health Sciences ; Microelectrodes ; Monkeys & apes ; Motor cortex ; Motor Cortex - physiology ; Motor skill learning ; Motor task performance ; Movement - physiology ; Neural oscillations ; Neurophysiology ; Novels ; Rats ; Rats, Long-Evans ; Recovery ; Rehabilitation ; Research and Analysis Methods ; Rodents ; Spiking ; Stability ; Temporal lobe ; Temporal resolution</subject><ispartof>PloS one, 2019-10, Vol.14 (10), p.e0219034-e0219034</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Bundy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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This study examined the stability of task-related neural activity associated with execution of two distinct reaching tasks in healthy rodents. A novel automated rodent behavioral apparatus was constructed and rats were trained to perform a reaching task combining a 'gross' lever press and a 'fine' pellet retrieval. In each animal, two chronic microelectrode arrays were implanted in motor cortex spanning the caudal forelimb area (rodent primary motor cortex) and the rostral forelimb area (rodent premotor cortex). We recorded multiunit spiking and local field potential activity from 10 days to 7-10 weeks post-implantation to characterize the patterns of neural activity observed during each task component and analyzed the consistency of channel-specific task-related neural activity. Task-related changes in neural activity were observed on the majority of channels. 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This study examined the stability of task-related neural activity associated with execution of two distinct reaching tasks in healthy rodents. A novel automated rodent behavioral apparatus was constructed and rats were trained to perform a reaching task combining a 'gross' lever press and a 'fine' pellet retrieval. In each animal, two chronic microelectrode arrays were implanted in motor cortex spanning the caudal forelimb area (rodent primary motor cortex) and the rostral forelimb area (rodent premotor cortex). We recorded multiunit spiking and local field potential activity from 10 days to 7-10 weeks post-implantation to characterize the patterns of neural activity observed during each task component and analyzed the consistency of channel-specific task-related neural activity. Task-related changes in neural activity were observed on the majority of channels. While the task-related changes in multi-unit spiking and local field potential spectral power were consistent over several weeks, spectral power changes were more stable, despite the trade-off of decreased spatial and temporal resolution. These results show that neural activity in rodent primary and premotor cortex is associated with specific phases of reaching movements with stable patterns of task-related activity across time, establishing the relevance of the rodent for future studies designed to examine changes in task-related neural activity during recovery from focal cortical lesions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31665145</pmid><doi>10.1371/journal.pone.0219034</doi><tpages>e0219034</tpages><orcidid>https://orcid.org/0000-0001-6491-044X</orcidid><orcidid>https://orcid.org/0000-0002-8559-2361</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals Automation Behavior Biology and Life Sciences Brain Cortex (motor) Cortex (premotor) Cortex (temporal) Electrophysiological recording Engineering and Technology Forelimb - physiology Future predictions Implantation Laboratory rats Male Medicine and Health Sciences Microelectrodes Monkeys & apes Motor cortex Motor Cortex - physiology Motor skill learning Motor task performance Movement - physiology Neural oscillations Neurophysiology Novels Rats Rats, Long-Evans Recovery Rehabilitation Research and Analysis Methods Rodents Spiking Stability Temporal lobe Temporal resolution |
| title | Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat |
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