Common variants in glyoxalase I do not increase chronic pancreatitis risk
Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS....
Gespeichert in:
| Veröffentlicht in: | PloS one 2019-10, Vol.14 (10), p.e0222927-e0222927 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0222927 |
|---|---|
| container_issue | 10 |
| container_start_page | e0222927 |
| container_title | PloS one |
| container_volume | 14 |
| creator | Kaune, Tom Hollenbach, Marcus Keil, Bettina Chen, Jian-Min Masson, Emmanuelle Becker, Carla Damm, Marko Ruffert, Claudia Grützmann, Robert Hoffmeister, Albrecht Te Morsche, Rene H M Cavestro, Giulia Martina Zuppardo, Raffaella Alessia Saftoiu, Adrian Malecka-Panas, Ewa Głuszek, Stanislaw Bugert, Peter Lerch, Markus M Weiss, Frank Ulrich Zou, Wen-Bin Liao, Zhuan Hegyi, Peter Drenth, Joost Ph Riedel, Jan Férec, Claude Scholz, Markus Kirsten, Holger Tóth, Andrea Ewers, Maren Witt, Heiko Griesmann, Heidi Michl, Patrick Rosendahl, Jonas |
| description | Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases. Here, we analyzed whether common GLO1 variants are associated with alcoholic (ACP) and non-alcoholic CP (NACP).
Using melting curve analysis, we genotyped a screening cohort of 223 ACP, 218 NACP patients, and 328 controls for 11 tagging SNPs defined by the SNPinfo LD TAG SNP Selection tool and the functionally relevant variant rs4746. For selected variants the cohorts were extended to up to 1,441 patient samples.
In the ACP cohort, comparison of genotypes for rs1937780 between patients and controls displayed an ambiguous result in the screening cohort (p = 0.08). However, in the extended cohort of 1,441 patients no statistically significant association was found for the comparison of genotypes (p = 0.11), nor in logistic regression analysis (p = 0.214, OR 1.072, 95% CI 0.961-1.196). In the NACP screening cohort SNPs rs937662, rs1699012, and rs4746 displayed an ambiguous result when patients were compared to controls in the recessive or dominant model (p = 0.08, 0.08, and 0.07, respectively). Again, these associations were not confirmed in the extended cohorts (rs937662, dominant model: p = 0.07, logistic regression: p = 0.07, OR 1.207, 95% CI 0.985-1.480) or in the replication cohorts for rs4746 (Germany, p = 0.42, OR 1.080, 95% CI 0.673-1.124; France, p = 0.19, OR 0.90, 95% CI 0.76-1.06; China, p = 0.24, OR 1.18, 95% CI 0.90-1.54) and rs1699012 (Germany, Munich; p = 0.279, OR 0.903, 95% CI 0.750-1.087).
Common GLO1 variants do not increase chronic pancreatitis risk. |
| doi_str_mv | 10.1371/journal.pone.0222927 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2310275911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A604140362</galeid><doaj_id>oai_doaj_org_article_0b1930c4b69842dcaa5299eec41f9046</doaj_id><sourcerecordid>A604140362</sourcerecordid><originalsourceid>FETCH-LOGICAL-c571t-6d7de161a0447fcb0129a3d3a88803231b5ff519389a9bf1dc710eb27c32ae7a3</originalsourceid><addsrcrecordid>eNqNkltr3DAQhU1padK0_6C0hkJpH3ariy1bL4Ww9LIQCPT2KsayvKutLG0lOST_vnLWCeuSh-IHm6NvzmjGJ8teYrTEtMIfdm7wFsxy76xaIkIIJ9Wj7BRzShaMIPr46PskexbCDqGS1ow9zU4oZgyXtDjN1ivX987mV-A12BhybfONuXHXYCCofJ23LrcuJll6NSpy653VMt_DrRJ11CH3Ovx-nj3pwAT1YnqfZT8_f_qx-rq4uPyyXp1fLGRZ4bhgbdUqzDCgoqg62SBMONCWQl3XiBKKm7LrynTzmgNvOtzKCiPVkEpSAqoCepa9PvjujQti2kIQqRKRquQYJ2J9IFoHO7H3ugd_IxxocSs4vxHgo5ZGCdSkTkgWDeN1QVoJUBLOlZIF7jgqWPL6OHUbml61UtnowcxM5ydWb8XGXQlW43GgZPBuMvDuz6BCFL0OUhkDVrnhcG_GGEckoW_-QR-ebqI2kAbQtnOprxxNxTlDBS4QZaPX8gEqPa3qtUyR6XTSZwXvZwWJieo6bmAIQay_f_t_9vLXnH17xG4VmLgNzgxROxvmYHEApXcheNXdLxkjMSb-bhtiTLyYEp_KXh3_oPuiu4jTv5iy-bw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2310275911</pqid></control><display><type>article</type><title>Common variants in glyoxalase I do not increase chronic pancreatitis risk</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Kaune, Tom ; Hollenbach, Marcus ; Keil, Bettina ; Chen, Jian-Min ; Masson, Emmanuelle ; Becker, Carla ; Damm, Marko ; Ruffert, Claudia ; Grützmann, Robert ; Hoffmeister, Albrecht ; Te Morsche, Rene H M ; Cavestro, Giulia Martina ; Zuppardo, Raffaella Alessia ; Saftoiu, Adrian ; Malecka-Panas, Ewa ; Głuszek, Stanislaw ; Bugert, Peter ; Lerch, Markus M ; Weiss, Frank Ulrich ; Zou, Wen-Bin ; Liao, Zhuan ; Hegyi, Peter ; Drenth, Joost Ph ; Riedel, Jan ; Férec, Claude ; Scholz, Markus ; Kirsten, Holger ; Tóth, Andrea ; Ewers, Maren ; Witt, Heiko ; Griesmann, Heidi ; Michl, Patrick ; Rosendahl, Jonas</creator><creatorcontrib>Kaune, Tom ; Hollenbach, Marcus ; Keil, Bettina ; Chen, Jian-Min ; Masson, Emmanuelle ; Becker, Carla ; Damm, Marko ; Ruffert, Claudia ; Grützmann, Robert ; Hoffmeister, Albrecht ; Te Morsche, Rene H M ; Cavestro, Giulia Martina ; Zuppardo, Raffaella Alessia ; Saftoiu, Adrian ; Malecka-Panas, Ewa ; Głuszek, Stanislaw ; Bugert, Peter ; Lerch, Markus M ; Weiss, Frank Ulrich ; Zou, Wen-Bin ; Liao, Zhuan ; Hegyi, Peter ; Drenth, Joost Ph ; Riedel, Jan ; Férec, Claude ; Scholz, Markus ; Kirsten, Holger ; Tóth, Andrea ; Ewers, Maren ; Witt, Heiko ; Griesmann, Heidi ; Michl, Patrick ; Rosendahl, Jonas</creatorcontrib><description>Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases. Here, we analyzed whether common GLO1 variants are associated with alcoholic (ACP) and non-alcoholic CP (NACP).
Using melting curve analysis, we genotyped a screening cohort of 223 ACP, 218 NACP patients, and 328 controls for 11 tagging SNPs defined by the SNPinfo LD TAG SNP Selection tool and the functionally relevant variant rs4746. For selected variants the cohorts were extended to up to 1,441 patient samples.
In the ACP cohort, comparison of genotypes for rs1937780 between patients and controls displayed an ambiguous result in the screening cohort (p = 0.08). However, in the extended cohort of 1,441 patients no statistically significant association was found for the comparison of genotypes (p = 0.11), nor in logistic regression analysis (p = 0.214, OR 1.072, 95% CI 0.961-1.196). In the NACP screening cohort SNPs rs937662, rs1699012, and rs4746 displayed an ambiguous result when patients were compared to controls in the recessive or dominant model (p = 0.08, 0.08, and 0.07, respectively). Again, these associations were not confirmed in the extended cohorts (rs937662, dominant model: p = 0.07, logistic regression: p = 0.07, OR 1.207, 95% CI 0.985-1.480) or in the replication cohorts for rs4746 (Germany, p = 0.42, OR 1.080, 95% CI 0.673-1.124; France, p = 0.19, OR 0.90, 95% CI 0.76-1.06; China, p = 0.24, OR 1.18, 95% CI 0.90-1.54) and rs1699012 (Germany, Munich; p = 0.279, OR 0.903, 95% CI 0.750-1.087).
Common GLO1 variants do not increase chronic pancreatitis risk.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0222927</identifier><identifier>PMID: 31661534</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Advanced glycosylation end products ; Aging (Biology) ; Biology and Life Sciences ; Cancer ; Chromosomes ; Development and progression ; Endoscopy ; Epidemiology ; Female ; Fibrosis ; Gastroenterology ; Genetic Association Studies ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Glycation End Products, Advanced - genetics ; Glycosylation ; Health aspects ; Health informatics ; Hepatology ; Humans ; Infectious diseases ; Inflammatory diseases ; Internal medicine ; Lactoylglutathione lyase ; Lactoylglutathione Lyase - genetics ; Male ; Medicine ; Medicine and Health Sciences ; Melting curve ; Middle Aged ; Nucleotides ; Oxidative stress ; Oxidative Stress - genetics ; Oxygen ; Pancreatitis ; Pancreatitis, Alcoholic - genetics ; Pancreatitis, Alcoholic - metabolism ; Pancreatitis, Alcoholic - pathology ; Pancreatitis, Chronic - genetics ; Pancreatitis, Chronic - metabolism ; Pancreatitis, Chronic - pathology ; People and Places ; Physical Sciences ; Polymorphism, Single Nucleotide - genetics ; Pyruvaldehyde ; Pyruvaldehyde - metabolism ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Regression analysis ; Research and Analysis Methods ; Risk Factors ; Screening ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Social Sciences ; Statistical analysis ; Statistical methods ; Tagging</subject><ispartof>PloS one, 2019-10, Vol.14 (10), p.e0222927-e0222927</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Kaune et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Kaune et al 2019 Kaune et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c571t-6d7de161a0447fcb0129a3d3a88803231b5ff519389a9bf1dc710eb27c32ae7a3</cites><orcidid>0000-0001-7752-0459 ; 0000-0002-3126-7950 ; 0000-0002-9643-8263 ; 0000-0003-4513-0506 ; 0000-0002-2424-3969 ; 0000-0002-4059-1779</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818803/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818803/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31661534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaune, Tom</creatorcontrib><creatorcontrib>Hollenbach, Marcus</creatorcontrib><creatorcontrib>Keil, Bettina</creatorcontrib><creatorcontrib>Chen, Jian-Min</creatorcontrib><creatorcontrib>Masson, Emmanuelle</creatorcontrib><creatorcontrib>Becker, Carla</creatorcontrib><creatorcontrib>Damm, Marko</creatorcontrib><creatorcontrib>Ruffert, Claudia</creatorcontrib><creatorcontrib>Grützmann, Robert</creatorcontrib><creatorcontrib>Hoffmeister, Albrecht</creatorcontrib><creatorcontrib>Te Morsche, Rene H M</creatorcontrib><creatorcontrib>Cavestro, Giulia Martina</creatorcontrib><creatorcontrib>Zuppardo, Raffaella Alessia</creatorcontrib><creatorcontrib>Saftoiu, Adrian</creatorcontrib><creatorcontrib>Malecka-Panas, Ewa</creatorcontrib><creatorcontrib>Głuszek, Stanislaw</creatorcontrib><creatorcontrib>Bugert, Peter</creatorcontrib><creatorcontrib>Lerch, Markus M</creatorcontrib><creatorcontrib>Weiss, Frank Ulrich</creatorcontrib><creatorcontrib>Zou, Wen-Bin</creatorcontrib><creatorcontrib>Liao, Zhuan</creatorcontrib><creatorcontrib>Hegyi, Peter</creatorcontrib><creatorcontrib>Drenth, Joost Ph</creatorcontrib><creatorcontrib>Riedel, Jan</creatorcontrib><creatorcontrib>Férec, Claude</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>Kirsten, Holger</creatorcontrib><creatorcontrib>Tóth, Andrea</creatorcontrib><creatorcontrib>Ewers, Maren</creatorcontrib><creatorcontrib>Witt, Heiko</creatorcontrib><creatorcontrib>Griesmann, Heidi</creatorcontrib><creatorcontrib>Michl, Patrick</creatorcontrib><creatorcontrib>Rosendahl, Jonas</creatorcontrib><title>Common variants in glyoxalase I do not increase chronic pancreatitis risk</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases. Here, we analyzed whether common GLO1 variants are associated with alcoholic (ACP) and non-alcoholic CP (NACP).
Using melting curve analysis, we genotyped a screening cohort of 223 ACP, 218 NACP patients, and 328 controls for 11 tagging SNPs defined by the SNPinfo LD TAG SNP Selection tool and the functionally relevant variant rs4746. For selected variants the cohorts were extended to up to 1,441 patient samples.
In the ACP cohort, comparison of genotypes for rs1937780 between patients and controls displayed an ambiguous result in the screening cohort (p = 0.08). However, in the extended cohort of 1,441 patients no statistically significant association was found for the comparison of genotypes (p = 0.11), nor in logistic regression analysis (p = 0.214, OR 1.072, 95% CI 0.961-1.196). In the NACP screening cohort SNPs rs937662, rs1699012, and rs4746 displayed an ambiguous result when patients were compared to controls in the recessive or dominant model (p = 0.08, 0.08, and 0.07, respectively). Again, these associations were not confirmed in the extended cohorts (rs937662, dominant model: p = 0.07, logistic regression: p = 0.07, OR 1.207, 95% CI 0.985-1.480) or in the replication cohorts for rs4746 (Germany, p = 0.42, OR 1.080, 95% CI 0.673-1.124; France, p = 0.19, OR 0.90, 95% CI 0.76-1.06; China, p = 0.24, OR 1.18, 95% CI 0.90-1.54) and rs1699012 (Germany, Munich; p = 0.279, OR 0.903, 95% CI 0.750-1.087).
Common GLO1 variants do not increase chronic pancreatitis risk.</description><subject>Advanced glycosylation end products</subject><subject>Aging (Biology)</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Chromosomes</subject><subject>Development and progression</subject><subject>Endoscopy</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Genetic Association Studies</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Glycation End Products, Advanced - genetics</subject><subject>Glycosylation</subject><subject>Health aspects</subject><subject>Health informatics</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammatory diseases</subject><subject>Internal medicine</subject><subject>Lactoylglutathione lyase</subject><subject>Lactoylglutathione Lyase - genetics</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Melting curve</subject><subject>Middle Aged</subject><subject>Nucleotides</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - genetics</subject><subject>Oxygen</subject><subject>Pancreatitis</subject><subject>Pancreatitis, Alcoholic - genetics</subject><subject>Pancreatitis, Alcoholic - metabolism</subject><subject>Pancreatitis, Alcoholic - pathology</subject><subject>Pancreatitis, Chronic - genetics</subject><subject>Pancreatitis, Chronic - metabolism</subject><subject>Pancreatitis, Chronic - pathology</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Pyruvaldehyde</subject><subject>Pyruvaldehyde - metabolism</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Risk Factors</subject><subject>Screening</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Social Sciences</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Tagging</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkltr3DAQhU1padK0_6C0hkJpH3ariy1bL4Ww9LIQCPT2KsayvKutLG0lOST_vnLWCeuSh-IHm6NvzmjGJ8teYrTEtMIfdm7wFsxy76xaIkIIJ9Wj7BRzShaMIPr46PskexbCDqGS1ow9zU4oZgyXtDjN1ivX987mV-A12BhybfONuXHXYCCofJ23LrcuJll6NSpy653VMt_DrRJ11CH3Ovx-nj3pwAT1YnqfZT8_f_qx-rq4uPyyXp1fLGRZ4bhgbdUqzDCgoqg62SBMONCWQl3XiBKKm7LrynTzmgNvOtzKCiPVkEpSAqoCepa9PvjujQti2kIQqRKRquQYJ2J9IFoHO7H3ugd_IxxocSs4vxHgo5ZGCdSkTkgWDeN1QVoJUBLOlZIF7jgqWPL6OHUbml61UtnowcxM5ydWb8XGXQlW43GgZPBuMvDuz6BCFL0OUhkDVrnhcG_GGEckoW_-QR-ebqI2kAbQtnOprxxNxTlDBS4QZaPX8gEqPa3qtUyR6XTSZwXvZwWJieo6bmAIQay_f_t_9vLXnH17xG4VmLgNzgxROxvmYHEApXcheNXdLxkjMSb-bhtiTLyYEp_KXh3_oPuiu4jTv5iy-bw</recordid><startdate>20191029</startdate><enddate>20191029</enddate><creator>Kaune, Tom</creator><creator>Hollenbach, Marcus</creator><creator>Keil, Bettina</creator><creator>Chen, Jian-Min</creator><creator>Masson, Emmanuelle</creator><creator>Becker, Carla</creator><creator>Damm, Marko</creator><creator>Ruffert, Claudia</creator><creator>Grützmann, Robert</creator><creator>Hoffmeister, Albrecht</creator><creator>Te Morsche, Rene H M</creator><creator>Cavestro, Giulia Martina</creator><creator>Zuppardo, Raffaella Alessia</creator><creator>Saftoiu, Adrian</creator><creator>Malecka-Panas, Ewa</creator><creator>Głuszek, Stanislaw</creator><creator>Bugert, Peter</creator><creator>Lerch, Markus M</creator><creator>Weiss, Frank Ulrich</creator><creator>Zou, Wen-Bin</creator><creator>Liao, Zhuan</creator><creator>Hegyi, Peter</creator><creator>Drenth, Joost Ph</creator><creator>Riedel, Jan</creator><creator>Férec, Claude</creator><creator>Scholz, Markus</creator><creator>Kirsten, Holger</creator><creator>Tóth, Andrea</creator><creator>Ewers, Maren</creator><creator>Witt, Heiko</creator><creator>Griesmann, Heidi</creator><creator>Michl, Patrick</creator><creator>Rosendahl, Jonas</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7752-0459</orcidid><orcidid>https://orcid.org/0000-0002-3126-7950</orcidid><orcidid>https://orcid.org/0000-0002-9643-8263</orcidid><orcidid>https://orcid.org/0000-0003-4513-0506</orcidid><orcidid>https://orcid.org/0000-0002-2424-3969</orcidid><orcidid>https://orcid.org/0000-0002-4059-1779</orcidid></search><sort><creationdate>20191029</creationdate><title>Common variants in glyoxalase I do not increase chronic pancreatitis risk</title><author>Kaune, Tom ; Hollenbach, Marcus ; Keil, Bettina ; Chen, Jian-Min ; Masson, Emmanuelle ; Becker, Carla ; Damm, Marko ; Ruffert, Claudia ; Grützmann, Robert ; Hoffmeister, Albrecht ; Te Morsche, Rene H M ; Cavestro, Giulia Martina ; Zuppardo, Raffaella Alessia ; Saftoiu, Adrian ; Malecka-Panas, Ewa ; Głuszek, Stanislaw ; Bugert, Peter ; Lerch, Markus M ; Weiss, Frank Ulrich ; Zou, Wen-Bin ; Liao, Zhuan ; Hegyi, Peter ; Drenth, Joost Ph ; Riedel, Jan ; Férec, Claude ; Scholz, Markus ; Kirsten, Holger ; Tóth, Andrea ; Ewers, Maren ; Witt, Heiko ; Griesmann, Heidi ; Michl, Patrick ; Rosendahl, Jonas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-6d7de161a0447fcb0129a3d3a88803231b5ff519389a9bf1dc710eb27c32ae7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Advanced glycosylation end products</topic><topic>Aging (Biology)</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Chromosomes</topic><topic>Development and progression</topic><topic>Endoscopy</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Genetic Association Studies</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Glycation End Products, Advanced - genetics</topic><topic>Glycosylation</topic><topic>Health aspects</topic><topic>Health informatics</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammatory diseases</topic><topic>Internal medicine</topic><topic>Lactoylglutathione lyase</topic><topic>Lactoylglutathione Lyase - genetics</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Melting curve</topic><topic>Middle Aged</topic><topic>Nucleotides</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - genetics</topic><topic>Oxygen</topic><topic>Pancreatitis</topic><topic>Pancreatitis, Alcoholic - genetics</topic><topic>Pancreatitis, Alcoholic - metabolism</topic><topic>Pancreatitis, Alcoholic - pathology</topic><topic>Pancreatitis, Chronic - genetics</topic><topic>Pancreatitis, Chronic - metabolism</topic><topic>Pancreatitis, Chronic - pathology</topic><topic>People and Places</topic><topic>Physical Sciences</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Pyruvaldehyde</topic><topic>Pyruvaldehyde - metabolism</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Regression analysis</topic><topic>Research and Analysis Methods</topic><topic>Risk Factors</topic><topic>Screening</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Social Sciences</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Tagging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaune, Tom</creatorcontrib><creatorcontrib>Hollenbach, Marcus</creatorcontrib><creatorcontrib>Keil, Bettina</creatorcontrib><creatorcontrib>Chen, Jian-Min</creatorcontrib><creatorcontrib>Masson, Emmanuelle</creatorcontrib><creatorcontrib>Becker, Carla</creatorcontrib><creatorcontrib>Damm, Marko</creatorcontrib><creatorcontrib>Ruffert, Claudia</creatorcontrib><creatorcontrib>Grützmann, Robert</creatorcontrib><creatorcontrib>Hoffmeister, Albrecht</creatorcontrib><creatorcontrib>Te Morsche, Rene H M</creatorcontrib><creatorcontrib>Cavestro, Giulia Martina</creatorcontrib><creatorcontrib>Zuppardo, Raffaella Alessia</creatorcontrib><creatorcontrib>Saftoiu, Adrian</creatorcontrib><creatorcontrib>Malecka-Panas, Ewa</creatorcontrib><creatorcontrib>Głuszek, Stanislaw</creatorcontrib><creatorcontrib>Bugert, Peter</creatorcontrib><creatorcontrib>Lerch, Markus M</creatorcontrib><creatorcontrib>Weiss, Frank Ulrich</creatorcontrib><creatorcontrib>Zou, Wen-Bin</creatorcontrib><creatorcontrib>Liao, Zhuan</creatorcontrib><creatorcontrib>Hegyi, Peter</creatorcontrib><creatorcontrib>Drenth, Joost Ph</creatorcontrib><creatorcontrib>Riedel, Jan</creatorcontrib><creatorcontrib>Férec, Claude</creatorcontrib><creatorcontrib>Scholz, Markus</creatorcontrib><creatorcontrib>Kirsten, Holger</creatorcontrib><creatorcontrib>Tóth, Andrea</creatorcontrib><creatorcontrib>Ewers, Maren</creatorcontrib><creatorcontrib>Witt, Heiko</creatorcontrib><creatorcontrib>Griesmann, Heidi</creatorcontrib><creatorcontrib>Michl, Patrick</creatorcontrib><creatorcontrib>Rosendahl, Jonas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaune, Tom</au><au>Hollenbach, Marcus</au><au>Keil, Bettina</au><au>Chen, Jian-Min</au><au>Masson, Emmanuelle</au><au>Becker, Carla</au><au>Damm, Marko</au><au>Ruffert, Claudia</au><au>Grützmann, Robert</au><au>Hoffmeister, Albrecht</au><au>Te Morsche, Rene H M</au><au>Cavestro, Giulia Martina</au><au>Zuppardo, Raffaella Alessia</au><au>Saftoiu, Adrian</au><au>Malecka-Panas, Ewa</au><au>Głuszek, Stanislaw</au><au>Bugert, Peter</au><au>Lerch, Markus M</au><au>Weiss, Frank Ulrich</au><au>Zou, Wen-Bin</au><au>Liao, Zhuan</au><au>Hegyi, Peter</au><au>Drenth, Joost Ph</au><au>Riedel, Jan</au><au>Férec, Claude</au><au>Scholz, Markus</au><au>Kirsten, Holger</au><au>Tóth, Andrea</au><au>Ewers, Maren</au><au>Witt, Heiko</au><au>Griesmann, Heidi</au><au>Michl, Patrick</au><au>Rosendahl, Jonas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common variants in glyoxalase I do not increase chronic pancreatitis risk</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-10-29</date><risdate>2019</risdate><volume>14</volume><issue>10</issue><spage>e0222927</spage><epage>e0222927</epage><pages>e0222927-e0222927</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases. Here, we analyzed whether common GLO1 variants are associated with alcoholic (ACP) and non-alcoholic CP (NACP).
Using melting curve analysis, we genotyped a screening cohort of 223 ACP, 218 NACP patients, and 328 controls for 11 tagging SNPs defined by the SNPinfo LD TAG SNP Selection tool and the functionally relevant variant rs4746. For selected variants the cohorts were extended to up to 1,441 patient samples.
In the ACP cohort, comparison of genotypes for rs1937780 between patients and controls displayed an ambiguous result in the screening cohort (p = 0.08). However, in the extended cohort of 1,441 patients no statistically significant association was found for the comparison of genotypes (p = 0.11), nor in logistic regression analysis (p = 0.214, OR 1.072, 95% CI 0.961-1.196). In the NACP screening cohort SNPs rs937662, rs1699012, and rs4746 displayed an ambiguous result when patients were compared to controls in the recessive or dominant model (p = 0.08, 0.08, and 0.07, respectively). Again, these associations were not confirmed in the extended cohorts (rs937662, dominant model: p = 0.07, logistic regression: p = 0.07, OR 1.207, 95% CI 0.985-1.480) or in the replication cohorts for rs4746 (Germany, p = 0.42, OR 1.080, 95% CI 0.673-1.124; France, p = 0.19, OR 0.90, 95% CI 0.76-1.06; China, p = 0.24, OR 1.18, 95% CI 0.90-1.54) and rs1699012 (Germany, Munich; p = 0.279, OR 0.903, 95% CI 0.750-1.087).
Common GLO1 variants do not increase chronic pancreatitis risk.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31661534</pmid><doi>10.1371/journal.pone.0222927</doi><tpages>e0222927</tpages><orcidid>https://orcid.org/0000-0001-7752-0459</orcidid><orcidid>https://orcid.org/0000-0002-3126-7950</orcidid><orcidid>https://orcid.org/0000-0002-9643-8263</orcidid><orcidid>https://orcid.org/0000-0003-4513-0506</orcidid><orcidid>https://orcid.org/0000-0002-2424-3969</orcidid><orcidid>https://orcid.org/0000-0002-4059-1779</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-10, Vol.14 (10), p.e0222927-e0222927 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2310275911 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Advanced glycosylation end products Aging (Biology) Biology and Life Sciences Cancer Chromosomes Development and progression Endoscopy Epidemiology Female Fibrosis Gastroenterology Genetic Association Studies Genetic polymorphisms Genetic Predisposition to Disease Genotype Genotypes Glycation End Products, Advanced - genetics Glycosylation Health aspects Health informatics Hepatology Humans Infectious diseases Inflammatory diseases Internal medicine Lactoylglutathione lyase Lactoylglutathione Lyase - genetics Male Medicine Medicine and Health Sciences Melting curve Middle Aged Nucleotides Oxidative stress Oxidative Stress - genetics Oxygen Pancreatitis Pancreatitis, Alcoholic - genetics Pancreatitis, Alcoholic - metabolism Pancreatitis, Alcoholic - pathology Pancreatitis, Chronic - genetics Pancreatitis, Chronic - metabolism Pancreatitis, Chronic - pathology People and Places Physical Sciences Polymorphism, Single Nucleotide - genetics Pyruvaldehyde Pyruvaldehyde - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Regression analysis Research and Analysis Methods Risk Factors Screening Single nucleotide polymorphisms Single-nucleotide polymorphism Social Sciences Statistical analysis Statistical methods Tagging |
| title | Common variants in glyoxalase I do not increase chronic pancreatitis risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T08%3A31%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Common%20variants%20in%20glyoxalase%20I%20do%20not%20increase%20chronic%20pancreatitis%20risk&rft.jtitle=PloS%20one&rft.au=Kaune,%20Tom&rft.date=2019-10-29&rft.volume=14&rft.issue=10&rft.spage=e0222927&rft.epage=e0222927&rft.pages=e0222927-e0222927&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0222927&rft_dat=%3Cgale_plos_%3EA604140362%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2310275911&rft_id=info:pmid/31661534&rft_galeid=A604140362&rft_doaj_id=oai_doaj_org_article_0b1930c4b69842dcaa5299eec41f9046&rfr_iscdi=true |