Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn's disease and ulcerative colitis
Faecal calprotectin (FC) seems to be the best available biomarker for the detection of intestinal inflammation in patients with inflammatory bowel disease (IBD). The aim of this study is to clarify whether the measurement of FC has changed the number of ultrasound and endoscopic procedures, drug mod...
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| creator | Bathe, Anna Luisa Mavropoulou, Eirini Mechie, Nicolae-Catalin Petzold, Golo Ellenrieder, Volker Kunsch, Steffen Amanzada, Ahmad |
| description | Faecal calprotectin (FC) seems to be the best available biomarker for the detection of intestinal inflammation in patients with inflammatory bowel disease (IBD). The aim of this study is to clarify whether the measurement of FC has changed the number of ultrasound and endoscopic procedures, drug modifications, as well as FC re-measurements in IBD patients.
This retrospective study included 242 IBD patients with available FC values (case cohort) and 46 patients without an available FC value (control cohort). Clinical consequences such as carrying out abdominal ultrasound, endoscopy, drug modification or FC re-measurement at the next ambulatory presentation or during in-patient stay were collected. Statistical analysis was performed to determine the association between clinical decision-making and patient's characteristics, especially FC value.
Overall, 192 (67%) clinical consequences were noted in both cohorts. In the case cohort 174 (91%) implications were noted compared to 18 (9%) in the control cohort (P < 0.001). In the case cohort, significantly more clinical consequences were detected in patients with Crohn's disease (CD) as well as in ulcerative colitis (UC) patients with a FC value > 250 mg/Kg than in patients with a value of ≤ 250 mg/Kg. In CD patients with high FC values significantly increased numbers of abdominal ultrasounds, endoscopies and FC re-measurements were noted. In UC patients with high FC values significantly increased numbers of abdominal ultrasounds, drug modifications and FC re-measurements were noted.
Measurement of FC may alter physician's clinical decision-making in IBD patients beside other clinical and diagnostic parameters. Further prospective and survey studies are warranted to evaluate the influence of FC measurement in the daily clinical decision-making. |
| doi_str_mv | 10.1371/journal.pone.0223893 |
| format | Article |
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This retrospective study included 242 IBD patients with available FC values (case cohort) and 46 patients without an available FC value (control cohort). Clinical consequences such as carrying out abdominal ultrasound, endoscopy, drug modification or FC re-measurement at the next ambulatory presentation or during in-patient stay were collected. Statistical analysis was performed to determine the association between clinical decision-making and patient's characteristics, especially FC value.
Overall, 192 (67%) clinical consequences were noted in both cohorts. In the case cohort 174 (91%) implications were noted compared to 18 (9%) in the control cohort (P < 0.001). In the case cohort, significantly more clinical consequences were detected in patients with Crohn's disease (CD) as well as in ulcerative colitis (UC) patients with a FC value > 250 mg/Kg than in patients with a value of ≤ 250 mg/Kg. In CD patients with high FC values significantly increased numbers of abdominal ultrasounds, endoscopies and FC re-measurements were noted. In UC patients with high FC values significantly increased numbers of abdominal ultrasounds, drug modifications and FC re-measurements were noted.
Measurement of FC may alter physician's clinical decision-making in IBD patients beside other clinical and diagnostic parameters. Further prospective and survey studies are warranted to evaluate the influence of FC measurement in the daily clinical decision-making.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0223893</identifier><identifier>PMID: 31647834</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - metabolism ; Care and treatment ; Case-Control Studies ; Clinical Decision-Making ; Colitis ; Colitis, Ulcerative - diagnosis ; Colitis, Ulcerative - metabolism ; Colon ; Crohn Disease - diagnosis ; Crohn Disease - metabolism ; Crohn's disease ; Decision analysis ; Decision making ; Diagnostic systems ; Diagnostic Tests, Routine - methods ; Endoscopes ; Endoscopy ; Feces - chemistry ; Female ; Gastrointestinal diseases ; Humans ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestine ; Leukocyte L1 Antigen Complex - metabolism ; Male ; Medical research ; Medicine and Health Sciences ; Middle Aged ; NMR ; Nuclear magnetic resonance ; People and Places ; Physical Sciences ; Prognosis ; Research and Analysis Methods ; Retrospective Studies ; Severity of Illness Index ; Social Sciences ; Statistical analysis ; Ulcerative colitis ; Ultrasound</subject><ispartof>PloS one, 2019-10, Vol.14 (10), p.e0223893-e0223893</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Bathe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Bathe et al 2019 Bathe et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ed93d8a52e92a45d42152eedac66abd39cab58d48dd8a02bf2c1e4368165a8663</citedby><cites>FETCH-LOGICAL-c692t-ed93d8a52e92a45d42152eedac66abd39cab58d48dd8a02bf2c1e4368165a8663</cites><orcidid>0000-0002-0801-2087</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812761/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812761/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31647834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bonaz, Bruno</contributor><creatorcontrib>Bathe, Anna Luisa</creatorcontrib><creatorcontrib>Mavropoulou, Eirini</creatorcontrib><creatorcontrib>Mechie, Nicolae-Catalin</creatorcontrib><creatorcontrib>Petzold, Golo</creatorcontrib><creatorcontrib>Ellenrieder, Volker</creatorcontrib><creatorcontrib>Kunsch, Steffen</creatorcontrib><creatorcontrib>Amanzada, Ahmad</creatorcontrib><title>Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn's disease and ulcerative colitis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Faecal calprotectin (FC) seems to be the best available biomarker for the detection of intestinal inflammation in patients with inflammatory bowel disease (IBD). The aim of this study is to clarify whether the measurement of FC has changed the number of ultrasound and endoscopic procedures, drug modifications, as well as FC re-measurements in IBD patients.
This retrospective study included 242 IBD patients with available FC values (case cohort) and 46 patients without an available FC value (control cohort). Clinical consequences such as carrying out abdominal ultrasound, endoscopy, drug modification or FC re-measurement at the next ambulatory presentation or during in-patient stay were collected. Statistical analysis was performed to determine the association between clinical decision-making and patient's characteristics, especially FC value.
Overall, 192 (67%) clinical consequences were noted in both cohorts. In the case cohort 174 (91%) implications were noted compared to 18 (9%) in the control cohort (P < 0.001). In the case cohort, significantly more clinical consequences were detected in patients with Crohn's disease (CD) as well as in ulcerative colitis (UC) patients with a FC value > 250 mg/Kg than in patients with a value of ≤ 250 mg/Kg. In CD patients with high FC values significantly increased numbers of abdominal ultrasounds, endoscopies and FC re-measurements were noted. In UC patients with high FC values significantly increased numbers of abdominal ultrasounds, drug modifications and FC re-measurements were noted.
Measurement of FC may alter physician's clinical decision-making in IBD patients beside other clinical and diagnostic parameters. Further prospective and survey studies are warranted to evaluate the influence of FC measurement in the daily clinical decision-making.</description><subject>Adult</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Clinical Decision-Making</subject><subject>Colitis</subject><subject>Colitis, Ulcerative - diagnosis</subject><subject>Colitis, Ulcerative - metabolism</subject><subject>Colon</subject><subject>Crohn Disease - diagnosis</subject><subject>Crohn Disease - metabolism</subject><subject>Crohn's disease</subject><subject>Decision analysis</subject><subject>Decision making</subject><subject>Diagnostic systems</subject><subject>Diagnostic Tests, Routine - methods</subject><subject>Endoscopes</subject><subject>Endoscopy</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Gastrointestinal diseases</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Intestine</subject><subject>Leukocyte L1 Antigen Complex - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bathe, Anna Luisa</au><au>Mavropoulou, Eirini</au><au>Mechie, Nicolae-Catalin</au><au>Petzold, Golo</au><au>Ellenrieder, Volker</au><au>Kunsch, Steffen</au><au>Amanzada, Ahmad</au><au>Bonaz, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn's disease and ulcerative colitis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-10-24</date><risdate>2019</risdate><volume>14</volume><issue>10</issue><spage>e0223893</spage><epage>e0223893</epage><pages>e0223893-e0223893</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Faecal calprotectin (FC) seems to be the best available biomarker for the detection of intestinal inflammation in patients with inflammatory bowel disease (IBD). The aim of this study is to clarify whether the measurement of FC has changed the number of ultrasound and endoscopic procedures, drug modifications, as well as FC re-measurements in IBD patients.
This retrospective study included 242 IBD patients with available FC values (case cohort) and 46 patients without an available FC value (control cohort). Clinical consequences such as carrying out abdominal ultrasound, endoscopy, drug modification or FC re-measurement at the next ambulatory presentation or during in-patient stay were collected. Statistical analysis was performed to determine the association between clinical decision-making and patient's characteristics, especially FC value.
Overall, 192 (67%) clinical consequences were noted in both cohorts. In the case cohort 174 (91%) implications were noted compared to 18 (9%) in the control cohort (P < 0.001). In the case cohort, significantly more clinical consequences were detected in patients with Crohn's disease (CD) as well as in ulcerative colitis (UC) patients with a FC value > 250 mg/Kg than in patients with a value of ≤ 250 mg/Kg. In CD patients with high FC values significantly increased numbers of abdominal ultrasounds, endoscopies and FC re-measurements were noted. In UC patients with high FC values significantly increased numbers of abdominal ultrasounds, drug modifications and FC re-measurements were noted.
Measurement of FC may alter physician's clinical decision-making in IBD patients beside other clinical and diagnostic parameters. Further prospective and survey studies are warranted to evaluate the influence of FC measurement in the daily clinical decision-making.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31647834</pmid><doi>10.1371/journal.pone.0223893</doi><tpages>e0223893</tpages><orcidid>https://orcid.org/0000-0002-0801-2087</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2019-10, Vol.14 (10), p.e0223893-e0223893 |
| issn | 1932-6203 1932-6203 |
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| recordid | cdi_plos_journals_2308692019 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Biological markers Biology and Life Sciences Biomarkers Biomarkers - metabolism Care and treatment Case-Control Studies Clinical Decision-Making Colitis Colitis, Ulcerative - diagnosis Colitis, Ulcerative - metabolism Colon Crohn Disease - diagnosis Crohn Disease - metabolism Crohn's disease Decision analysis Decision making Diagnostic systems Diagnostic Tests, Routine - methods Endoscopes Endoscopy Feces - chemistry Female Gastrointestinal diseases Humans Inflammation Inflammatory bowel disease Inflammatory bowel diseases Intestine Leukocyte L1 Antigen Complex - metabolism Male Medical research Medicine and Health Sciences Middle Aged NMR Nuclear magnetic resonance People and Places Physical Sciences Prognosis Research and Analysis Methods Retrospective Studies Severity of Illness Index Social Sciences Statistical analysis Ulcerative colitis Ultrasound |
| title | Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn's disease and ulcerative colitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T19%3A58%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20faecal%20calprotectin%20measurement%20on%20clinical%20decision-making%20in%20patients%20with%20Crohn's%20disease%20and%20ulcerative%20colitis&rft.jtitle=PloS%20one&rft.au=Bathe,%20Anna%20Luisa&rft.date=2019-10-24&rft.volume=14&rft.issue=10&rft.spage=e0223893&rft.epage=e0223893&rft.pages=e0223893-e0223893&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0223893&rft_dat=%3Cgale_plos_%3EA603707642%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2308692019&rft_id=info:pmid/31647834&rft_galeid=A603707642&rft_doaj_id=oai_doaj_org_article_01ba70a575534fd4870525dbb9f173fa&rfr_iscdi=true |