Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction

Controlled inflammatory responses of myeloid cells recruited to wounds are essential for effective repair. In diabetes, the inflammatory response is prolonged and augmented over time, with increased myeloid cells present in the wound that fail to switch from a pro-inflammatory phenotype to a pro-hea...

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Veröffentlicht in:	PloS one 2019-10, Vol.14 (10), p.e0223980
Hauptverfasser:	Alrdahe, Salma, Al Sadoun, Hadeel, Torbica, Tanja, McKenzie, Edward A, Bowling, Frank L, Boulton, Andrew J M, Mace, Kimberly A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adult Angiogenesis Animal models Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - metabolism Biology Biology and Life Sciences Bone marrow Case-Control Studies Cell Survival - drug effects Cells, Cultured Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism Culture Media, Conditioned - chemistry Cytokines Defects Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetics EDTA Endocrinology Female Gastroenterology Genotype & phenotype Health aspects Histone acetyltransferase Histones Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Inflammation Inflammatory response Interleukin-6 - analysis Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Lipopolysaccharides Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Male Maturation Medicare Medicine Medicine and Health Sciences Middle Aged Myeloid cells Neutrophils NF-κB protein Peripheral blood mononuclear cells Phenotype Phenotypes Priming Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification Recombinant Proteins - pharmacology Regeneration Repair Risk factors Runx1 protein Stem cells Transcription factors Tumor necrosis factor Tumor necrosis factor-TNF Tumor Necrosis Factors - analysis Tumor Necrosis Factors - metabolism Ulcers Up-Regulation - drug effects Vascular endothelial growth factor Wound healing Wounds
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