Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach

A comparative analysis of blood samples (depleted of albumin and IgG) obtained from lung cancer patients before chemotherapy versus after a second cycle of chemotherapy was performed using two-dimensional difference gel electrophoresis (2D-DIGE). The control group consisted of eight patients with no...

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Veröffentlicht in:	PloS one 2019-10, Vol.14 (10), p.e0223840-e0223840
Hauptverfasser:	Ciereszko, Andrzej, Dietrich, Mariola A, Słowińska, Mariola, Nynca, Joanna, Ciborowski, Michał, Kisluk, Joanna, Michalska-Falkowska, Anna, Reszec, Joanna, Sierko, Ewa, Nikliński, Jacek
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute phase proteins Acute phase substances Adenocarcinoma Adenocarcinoma - blood Adenocarcinoma - drug therapy Adenocarcinoma - pathology Aged Albumins Anemia Antigens Antineoplastic Agents - therapeutic use Biology and Life Sciences Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - metabolism Blood Blood plasma Blood Proteins - analysis Blood Proteins - metabolism Breast cancer Cancer therapies Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Chemotherapy Clusterin Comparative analysis Complement component C3 Electrophoresis Female Food Gel electrophoresis Gels Growth factors Haptoglobin Humans Immunoglobulin G Iron Labeling Lung cancer Lung diseases Lung Neoplasms - blood Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Mass Spectrometry Medical prognosis Medicine and Health Sciences Middle Aged Molecular biology Phosphorylation Plasma proteins Proteins Proteomics Research and Analysis Methods Squamous cell carcinoma Transferrin Transferrin - metabolism Transferrins Two dimensional analysis Two-Dimensional Difference Gel Electrophoresis - methods Vitronectin VOCs Volatile organic compounds
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