Pyruvate produced by Brugia spp. via glycolysis is essential for maintaining the mutualistic association between the parasite and its endosymbiont, Wolbachia

Human parasitic nematodes are the causative agents of lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), diseases that are endemic to more than 80 countries and that consistently rank in the top ten for the highest number of years lived with disability. These filarial nematod...

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Veröffentlicht in:	PLoS pathogens 2019-09, Vol.15 (9), p.e1008085
Hauptverfasser:	Voronin, Denis, Schnall, Emily, Grote, Alexandra, Jawahar, Shabnam, Ali, Waleed, Unnasch, Thomas R, Ghedin, Elodie, Lustigman, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Phosphofructokinase Analysis Animals Bacteria Biology Biology and Life Sciences Blindness Brugia - genetics Brugia - metabolism Brugia - microbiology Brugia malayi - genetics Brugia malayi - metabolism Brugia malayi - microbiology Brugia pahangi - genetics Brugia pahangi - metabolism Brugia pahangi - microbiology Cancer therapies Chemical properties Dehydrogenases Drug resistance Drug therapy Elephantiasis Energy metabolism Enzymes Female Filariasis Filariasis - metabolism Filariasis - microbiology Filariasis - parasitology Funding Gene expression Genes Genes, Helminth Genetic research Genomes Genomic analysis Genomics Gluconeogenesis Glucose Glucose metabolism Glycolysis Hexokinase Host Microbial Interactions Host-Parasite Interactions Host-parasite relationships Humans Hypoxia Infections Influence Intracellular Kinases L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lymphatic diseases Male Medicine and Health Sciences Metabolism Metabolites Molecular interactions Nematodes Novels Onchocerciasis Parasites Parasitology Phosphofructokinase Physical Sciences Public health Pyruvate kinase Pyruvic acid Pyruvic Acid - metabolism Rivers Roundworms Survival Symbiosis Tetracyclines Tricarboxylic acid cycle Tropical diseases Vector-borne diseases Wolbachia Wolbachia - genetics Wolbachia - metabolism Worms
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