Role of dynamic nuclear deformation on genomic architecture reorganization

Higher-order genomic architecture varies according to cell type and changes dramatically during differentiation. One of the remarkable examples of spatial genomic reorganization is the rod photoreceptor cell differentiation in nocturnal mammals. The inverted nuclear architecture found in adult mouse...

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Veröffentlicht in:	PLoS computational biology 2019-09, Vol.15 (9), p.e1007289-e1007289
Hauptverfasser:	Seirin-Lee, Sungrim, Osakada, Fumitaka, Takeda, Junichi, Tashiro, Satoshi, Kobayashi, Ryo, Yamamoto, Takashi, Ochiai, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin Animals Architecture Biology Biology and Life Sciences Cell adhesion & migration Cell differentiation Cell Differentiation - genetics Cell Nucleus - genetics Cell Nucleus - physiology Chromosome Structures - physiology Chromosome Structures - ultrastructure Chromosomes Clustering Computational Biology Contractility Cytological research Deoxyribonucleic acid Differentiation (biology) DNA Gene expression Genetic aspects Genomes Genomics Laboratories Life sciences Male Mammals Materials science Mice Mice, Inbred C57BL Models, Biological Nocturnal Nuclear deformation Nuclear membrane Nuclei Pharmaceutical sciences Photoreceptors Physical Sciences Physiological aspects Retina Retinal Rod Photoreceptor Cells - cytology Stem cells Supervision
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