Calreticulin is a Critical Cell Survival Factor in Malignant Neoplasms

Calreticulin (CRT) is a high-capacity Ca2+ protein whose expression is up-regulated during cellular transformation and is associated with disease progression in multiple types of malignancies. At the same time, CRT has been characterized as an important stress-response protein capable of inducing im...

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Veröffentlicht in:	PLoS biology 2019-09, Vol.17 (9), p.e3000402-e3000402
Hauptverfasser:	Han, Arum, Li, Chen, Zahed, Tara, Wong, Michael, Smith, Ian, Hoedel, Karl, Green, Douglas, Boiko, Alexander D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Analysis Apoptosis Biochemistry Biology and Life Sciences Calcium (mitochondrial) Calcium - metabolism Calcium ions Calcium permeability Calreticulin Calreticulin - metabolism Cancer Cancer cells Carcinogenesis Caspase Cell adhesion & migration Cell death Cell Line, Tumor Cell surface Cell survival Correlation analysis Cyclosporin A Down-Regulation Gene expression Health aspects Humans Immunogenicity Kinases Medical prognosis Medical research Melanoma Membrane permeability Mitochondria Mitochondrial permeability transition pore Mitochondrial Transmembrane Permeability-Driven Necrosis Molecular biology Molecular chaperones Mortality Neoplasms Neoplasms - metabolism Neoplasms - mortality p53 Protein Poly(ADP-ribose) polymerase Proteins Research and Analysis Methods Ribose Stem cells Survival Survival factor Therapeutic applications Transformation Tumor Suppressor Protein p53 - metabolism Tumors
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