Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis

Lymphatic filariasis (LF), a morbid disease caused by the tissue-invasive nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori, affects millions of people worldwide. Global eradication efforts have significantly reduced worldwide prevalence, but complete elimination has been hampered by...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-09, Vol.13 (9), p.e0007687
Hauptverfasser:	Flynn, Alexander F, Joyce, M Gordon, Taylor, Rebekah T, Bennuru, Sasisekhar, Lindrose, Alyssa R, Sterling, Spencer L, Morris, C Paul, Nutman, Thomas B, Mitre, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Albendazole Albendazole - pharmacology Animals Antigens Antigens, Helminth - blood Biology and Life Sciences Brugia malayi - drug effects Brugia malayi - enzymology Brugia malayi - immunology Brugia malayi - metabolism Care and treatment Disease control Drug development Drug Therapy, Combination Elephantiasis, Filarial - drug therapy Elephantiasis, Filarial - prevention & control Engineering and Technology Female Filariasis Filaricides - pharmacology Gene expression Glucuronosyltransferase Glucuronosyltransferase - antagonists & inhibitors Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Health aspects Health sciences Humans Immunoglobulin E Immunoglobulin E - blood Immunoprecipitation Infections Infectious diseases Intestine Intestines - enzymology Luciferase Lymphatic diseases Medical research Medicine Medicine and Health Sciences Messenger RNA Metabolism Microfilariae - drug effects Movement mRNA Nematodes Populations Prevention Probenecid Probenecid - pharmacology Proteins Reduction Research and Analysis Methods RNA RNA, Small Interfering Roundworms siRNA Sulfinpyrazone Sulfinpyrazone - pharmacology Survival Therapeutic applications Tropical diseases UDP-glucuronosyltransferase Vaccines Vector-borne diseases Worms
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