Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis

Somatic migration of Toxocara canis- and T. cati-larvae in humans may cause neurotoxocarosis (NT) when larvae accumulate and persist in the central nervous system (CNS). Host- or parasite-induced immunoregulatory processes contribute to the pathogenesis; however, detailed data on involvement of bioa...

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Veröffentlicht in:	PLoS neglected tropical diseases 2019-09, Vol.13 (9), p.e0007706
Hauptverfasser:	Waindok, Patrick, Janecek-Erfurth, Elisabeth, Lindenwald, Dimitri, Wilk, Esther, Schughart, Klaus, Geffers, Robert, Balas, Laurence, Durand, Thierry, Rund, Katharina Maria, Schebb, Nils Helge, Strube, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological activity Biology and Life Sciences Brain Brain - immunology Brain Chemistry Brain Diseases - immunology Brain Diseases - parasitology Brain research Central nervous system Change detection Chromatography COX-2 inhibitors Criminal investigation Defence mechanisms Docosahexaenoic Acids - immunology Enzymes Fatty acids Female Food Gene expression Health aspects Homeostasis Host-parasite interactions House mouse Human health and pathology Humans Immune response Immune system Immunity Immunology Immunoregulation Infection Infections Infectious diseases Inflammation Inflammation Mediators - chemistry Inflammation Mediators - immunology Inflammatory response Larva - physiology Larvae Life Sciences Lipids Lipoxygenase Mass spectrometry Mass spectroscopy Medicine and Health Sciences Metabolites Mice Mice, Inbred C57BL Neurobiology Neurons and Cognition Oxylipins - chemistry Oxylipins - immunology Parasites Parasitology Pathogenesis Pathogenic microorganisms Pathogens Physiological aspects Profiling Prostaglandin endoperoxide synthase Prostaglandins Roundworm infections Signal transduction Spectroscopy Suspended particulate matter Toxicology Toxocara canis Toxocara canis - physiology Toxocariasis - immunology Toxocariasis - parasitology Tropical diseases Veterinary medicine Zoonoses
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