Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains

Three human clinical isolates of bacteria (designated strains Em1, Em2 and Em3) had high average nucleotide identity (ANI) to Elizabethkingia meningoseptica. Their genome sizes (3.89, 4.04 and 4.04 Mb) were comparable to those of other Elizabethkingia species and strains, and exhibited open pan-geno...

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Veröffentlicht in:	PloS one 2019-10, Vol.14 (10), p.e0222648-e0222648
Hauptverfasser:	Chen, Shicheng, Soehnlen, Marty, Blom, Jochen, Terrapon, Nicolas, Henrissat, Bernard, Walker, Edward D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Antimicrobial resistance Bacteria Binding proteins Biofilms Biofilms - growth & development Biology and Life Sciences Ciprofloxacin Clinical isolates Clustered Regularly Interspaced Short Palindromic Repeats - genetics Comparative Genomic Hybridization CRISPR Deoxyribonucleic acid DNA DNA sequencing DNA-binding protein DNA-Binding Proteins - genetics Drug resistance Drug Resistance, Bacterial - genetics Efflux Epidemics Flavobacteriaceae - genetics Flavobacteriaceae - pathogenicity Flavobacteriaceae Infections - drug therapy Flavobacteriaceae Infections - epidemiology Flavobacteriaceae Infections - genetics Flavobacteriaceae Infections - microbiology Gene expression Genes Genetic aspects Genome, Bacterial - genetics Genomes Genomic analysis Genomics Genomics - methods Glycoside hydrolase Gram-negative bacteria Gram-positive bacteria Growth hormone Humans Hydrolases Infections Laboratories Life Sciences Medicine and Health Sciences Microbial drug resistance Nucleotides Organic acids Patients Phylogeny Physical Sciences Polysaccharides Prophages Protein binding Proteins Resistance factors Strains (organisms) Studies Sulfamethoxazole Tetracyclines Transcription (Genetics) Transcription Factors - genetics Trimethoprim Viral infections Virulence Virulence (Microbiology) Virulence factors Virulence Factors - genetics
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