Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal
Gastric emptying (GE) can be either delayed or accelerated in diabetes mellitus (DM). However, most research has focused on delayed GE mediated by a chronic hyperglycemic condition in DM. As such, the function of GE in the early stages of DM is not well understood. Interstitial cells of Cajal (ICC)...
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| creator | Kishi, Kazuhisa Kaji, Noriyuki Kurosawa, Tamaki Aikiyo, Satoshi Hori, Masatoshi |
| description | Gastric emptying (GE) can be either delayed or accelerated in diabetes mellitus (DM). However, most research has focused on delayed GE mediated by a chronic hyperglycemic condition in DM. As such, the function of GE in the early stages of DM is not well understood. Interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal tract. In the present study, we investigated changes in GE and ICC networks in the early stages of DM using a streptozotocin-induced type 1 diabetic mouse model. The changes in GE were measured by the 13C-octanoic acid breath test. ICC networks were immunohistochemically detected by an antibody for c-Kit, a specific marker for ICC. Our results showed that GE in type 1 DM was significantly accelerated in the early stages of DM (2-4 weeks after onset). In addition, acute normalization of blood glucose levels by a single administration of insulin did not recover normal GE. ICC networks of the gastric antrum were significantly increased in DM and were not affected by the acute normalization of blood glucose. In conclusion, our results suggest that GE is accelerated in the early stages of DM, and it is associated with increased ICC networks. This mechanism may help to clarify a link between the onset of DM and GE disorders. |
| doi_str_mv | 10.1371/journal.pone.0222961 |
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However, most research has focused on delayed GE mediated by a chronic hyperglycemic condition in DM. As such, the function of GE in the early stages of DM is not well understood. Interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal tract. In the present study, we investigated changes in GE and ICC networks in the early stages of DM using a streptozotocin-induced type 1 diabetic mouse model. The changes in GE were measured by the 13C-octanoic acid breath test. ICC networks were immunohistochemically detected by an antibody for c-Kit, a specific marker for ICC. Our results showed that GE in type 1 DM was significantly accelerated in the early stages of DM (2-4 weeks after onset). In addition, acute normalization of blood glucose levels by a single administration of insulin did not recover normal GE. ICC networks of the gastric antrum were significantly increased in DM and were not affected by the acute normalization of blood glucose. In conclusion, our results suggest that GE is accelerated in the early stages of DM, and it is associated with increased ICC networks. This mechanism may help to clarify a link between the onset of DM and GE disorders.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0222961</identifier><identifier>PMID: 31596858</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Animals ; Antibodies ; Biology and Life Sciences ; Blood ; Blood glucose ; Blood Glucose - metabolism ; Breath tests ; c-Kit protein ; Care and treatment ; Chronic illnesses ; Complications and side effects ; Control ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - physiopathology ; Disease Models, Animal ; Emptying ; Fatty acids ; Gastric Emptying ; Gastroenterology ; Gastrointestinal motility ; Gastrointestinal system ; Gastrointestinal tract ; Gene expression ; Glucose ; Health aspects ; Hyperglycemia ; Hyperglycemia - blood ; Hyperglycemia - complications ; Hyperglycemia - physiopathology ; Insulin ; Insulin - pharmacology ; Insulin - therapeutic use ; Insulin glargine ; Interstitial cells ; Interstitial cells of Cajal ; Interstitial Cells of Cajal - pathology ; Life sciences ; Male ; Medicine and Health Sciences ; Mice, Inbred C57BL ; Motility ; Networks ; Octanoic acid ; Oxidative stress ; Oxidative Stress - drug effects ; Pharmacology ; Prevention ; Proto-Oncogene Proteins c-kit - metabolism ; Research and Analysis Methods ; Risk factors ; Saturated fatty acids ; Streptozocin ; Tumors ; Type 1 diabetes</subject><ispartof>PloS one, 2019-10, Vol.14 (10), p.e0222961-e0222961</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Kishi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Kishi et al 2019 Kishi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-5248758c28d07aa66e225af6eb92eee710d8a981eebbd76be653e0183d2421203</citedby><cites>FETCH-LOGICAL-c758t-5248758c28d07aa66e225af6eb92eee710d8a981eebbd76be653e0183d2421203</cites><orcidid>0000-0003-2732-0648</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785066/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785066/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31596858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bader, Michael</contributor><creatorcontrib>Kishi, Kazuhisa</creatorcontrib><creatorcontrib>Kaji, Noriyuki</creatorcontrib><creatorcontrib>Kurosawa, Tamaki</creatorcontrib><creatorcontrib>Aikiyo, Satoshi</creatorcontrib><creatorcontrib>Hori, Masatoshi</creatorcontrib><title>Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Gastric emptying (GE) can be either delayed or accelerated in diabetes mellitus (DM). However, most research has focused on delayed GE mediated by a chronic hyperglycemic condition in DM. As such, the function of GE in the early stages of DM is not well understood. Interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal tract. In the present study, we investigated changes in GE and ICC networks in the early stages of DM using a streptozotocin-induced type 1 diabetic mouse model. The changes in GE were measured by the 13C-octanoic acid breath test. ICC networks were immunohistochemically detected by an antibody for c-Kit, a specific marker for ICC. Our results showed that GE in type 1 DM was significantly accelerated in the early stages of DM (2-4 weeks after onset). In addition, acute normalization of blood glucose levels by a single administration of insulin did not recover normal GE. ICC networks of the gastric antrum were significantly increased in DM and were not affected by the acute normalization of blood glucose. In conclusion, our results suggest that GE is accelerated in the early stages of DM, and it is associated with increased ICC networks. This mechanism may help to clarify a link between the onset of DM and GE disorders.</description><subject>Acids</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>Breath tests</subject><subject>c-Kit protein</subject><subject>Care and treatment</subject><subject>Chronic illnesses</subject><subject>Complications and side effects</subject><subject>Control</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Emptying</subject><subject>Fatty acids</subject><subject>Gastric Emptying</subject><subject>Gastroenterology</subject><subject>Gastrointestinal motility</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Gene expression</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - blood</subject><subject>Hyperglycemia - complications</subject><subject>Hyperglycemia - physiopathology</subject><subject>Insulin</subject><subject>Insulin - pharmacology</subject><subject>Insulin - therapeutic use</subject><subject>Insulin glargine</subject><subject>Interstitial cells</subject><subject>Interstitial cells of Cajal</subject><subject>Interstitial Cells of Cajal - pathology</subject><subject>Life sciences</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mice, Inbred C57BL</subject><subject>Motility</subject><subject>Networks</subject><subject>Octanoic acid</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology</subject><subject>Prevention</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Saturated fatty acids</subject><subject>Streptozocin</subject><subject>Tumors</subject><subject>Type 1 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQQCMEoqXwBwgiISF42MWX2ElekKoK6EqVKnF7tSbOJOvFG29tB9hv4KfxXlrtoj6gPGQ0OXNsTzxZ9pySKeUlfbdwox_ATlduwClhjNWSPshOac3ZRDLCHx7EJ9mTEBaECF5J-Tg74VTUshLVafbncr1C39u1xqWB3Ax5nGOO4O06DxF6DLnr8pignOatgQZjSoHWaNHDJu4hRG90jstVXJuhTwLvxn6eXNojBGzzAeMv539sVWaI6EM00YDNk8VusxewAPs0e9SBDfhs_z7Lvn388PXicnJ1_Wl2cX410aWo4kSwokqBZlVLSgApkTEBncSmZohYUtJWUFcUsWnaUjYoBUdCK96ygtHUjbPs5c67si6ofR-DYpxwKkvKi0TMdkTrYKFW3izBr5UDo7YJ53sFPhptUTWEtRo7KrqmLgQRNQdKCloIXaTttm1yvd-vNjZLTOwQPdgj6fGXwcxV734qWVaCSJkEb_YC725GDFEtTdh0DgZ0427fZSGrmif01T_o_afbUz2kA5ihc2ldvZGqc0kYrZjgdaKm91DpadNN0enSdSbljwreHhUkJuLv2MMYgpp9-fz_7PX3Y_b1ATtHsHEenB2jcUM4BosdqL0LwWN312RK1GZmbruhNjOj9jOTyl4c_qC7otsh4X8BeHoTIQ</recordid><startdate>20191009</startdate><enddate>20191009</enddate><creator>Kishi, Kazuhisa</creator><creator>Kaji, Noriyuki</creator><creator>Kurosawa, Tamaki</creator><creator>Aikiyo, Satoshi</creator><creator>Hori, Masatoshi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2732-0648</orcidid></search><sort><creationdate>20191009</creationdate><title>Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal</title><author>Kishi, Kazuhisa ; Kaji, Noriyuki ; Kurosawa, Tamaki ; Aikiyo, Satoshi ; Hori, Masatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-5248758c28d07aa66e225af6eb92eee710d8a981eebbd76be653e0183d2421203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>Breath tests</topic><topic>c-Kit protein</topic><topic>Care and treatment</topic><topic>Chronic illnesses</topic><topic>Complications and side effects</topic><topic>Control</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Emptying</topic><topic>Fatty acids</topic><topic>Gastric Emptying</topic><topic>Gastroenterology</topic><topic>Gastrointestinal motility</topic><topic>Gastrointestinal system</topic><topic>Gastrointestinal tract</topic><topic>Gene expression</topic><topic>Glucose</topic><topic>Health aspects</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kishi, Kazuhisa</au><au>Kaji, Noriyuki</au><au>Kurosawa, Tamaki</au><au>Aikiyo, Satoshi</au><au>Hori, Masatoshi</au><au>Bader, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-10-09</date><risdate>2019</risdate><volume>14</volume><issue>10</issue><spage>e0222961</spage><epage>e0222961</epage><pages>e0222961-e0222961</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Gastric emptying (GE) can be either delayed or accelerated in diabetes mellitus (DM). However, most research has focused on delayed GE mediated by a chronic hyperglycemic condition in DM. As such, the function of GE in the early stages of DM is not well understood. Interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal tract. In the present study, we investigated changes in GE and ICC networks in the early stages of DM using a streptozotocin-induced type 1 diabetic mouse model. The changes in GE were measured by the 13C-octanoic acid breath test. ICC networks were immunohistochemically detected by an antibody for c-Kit, a specific marker for ICC. Our results showed that GE in type 1 DM was significantly accelerated in the early stages of DM (2-4 weeks after onset). In addition, acute normalization of blood glucose levels by a single administration of insulin did not recover normal GE. ICC networks of the gastric antrum were significantly increased in DM and were not affected by the acute normalization of blood glucose. In conclusion, our results suggest that GE is accelerated in the early stages of DM, and it is associated with increased ICC networks. This mechanism may help to clarify a link between the onset of DM and GE disorders.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31596858</pmid><doi>10.1371/journal.pone.0222961</doi><tpages>e0222961</tpages><orcidid>https://orcid.org/0000-0003-2732-0648</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2303167134 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acids Animals Antibodies Biology and Life Sciences Blood Blood glucose Blood Glucose - metabolism Breath tests c-Kit protein Care and treatment Chronic illnesses Complications and side effects Control Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Disease Models, Animal Emptying Fatty acids Gastric Emptying Gastroenterology Gastrointestinal motility Gastrointestinal system Gastrointestinal tract Gene expression Glucose Health aspects Hyperglycemia Hyperglycemia - blood Hyperglycemia - complications Hyperglycemia - physiopathology Insulin Insulin - pharmacology Insulin - therapeutic use Insulin glargine Interstitial cells Interstitial cells of Cajal Interstitial Cells of Cajal - pathology Life sciences Male Medicine and Health Sciences Mice, Inbred C57BL Motility Networks Octanoic acid Oxidative stress Oxidative Stress - drug effects Pharmacology Prevention Proto-Oncogene Proteins c-kit - metabolism Research and Analysis Methods Risk factors Saturated fatty acids Streptozocin Tumors Type 1 diabetes |
| title | Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T12%3A46%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperglycemia%20in%20the%20early%20stages%20of%20type%201%20diabetes%20accelerates%20gastric%20emptying%20through%20increased%20networks%20of%20interstitial%20cells%20of%20Cajal&rft.jtitle=PloS%20one&rft.au=Kishi,%20Kazuhisa&rft.date=2019-10-09&rft.volume=14&rft.issue=10&rft.spage=e0222961&rft.epage=e0222961&rft.pages=e0222961-e0222961&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0222961&rft_dat=%3Cgale_plos_%3EA602182539%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2303167134&rft_id=info:pmid/31596858&rft_galeid=A602182539&rft_doaj_id=oai_doaj_org_article_b02dcef15fb9450593a104145c4c75dd&rfr_iscdi=true |