No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer's disease
The earliest changes in the brain due to Alzheimer's disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among regions that support memory function in prodromal Alzheimer's disease, i.e., during the m...
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| description | The earliest changes in the brain due to Alzheimer's disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among regions that support memory function in prodromal Alzheimer's disease, i.e., during the mild cognitive impairment (MCI) stage.
Twenty-three older healthy controls and 25 adults with MCI underwent multimodal MRI scanning. Limbic white matter tracts-the fornix, parahippocampal cingulum, retrosplenial cingulum, subgenual cingulum and uncinate fasciculus-were reconstructed in ExploreDTI using constrained spherical deconvolution-based tractography. Using a network-of-interest approach, resting-state functional connectivity time-series correlations among sub-parcellations of the default mode and limbic networks, the hippocampus and the thalamus were calculated in Conn.
Controlling for age, education, and gender between group linear regressions of five diffusion-weighted measures and of resting state connectivity measures were performed per hemisphere. FDR-corrections were performed within each class of measures. Correlations of within-network Fisher Z-transformed correlation coefficients and the mean diffusivity per tract were performed. Whole-brain graph theory measures of cluster coefficient and average path length were inspecting using the resting state data.
MCI-related changes in white matter structure were found in the fornix, left parahippocampal cingulum, left retrosplenial cingulum and left subgenual cingulum. Functional connectivity decreases were observed in the MCI group within the DMN-a sub-network, between the hippocampus and sub-areas -a and -c of the DMN, between DMN-c and DMN-a, and, in the right hemisphere only between DMN-c and both the thalamus and limbic-a. No relationships between white matter tract 'integrity' (mean diffusivity) and within sub-network functional connectivity were found. Graph theory revealed that changes in the MCI group was mostly restricted to diminished between-neighbour connections of the hippocampi and of nodes within DMN-a and DMN-b. |
| doi_str_mv | 10.1371/journal.pone.0222977 |
| format | Article |
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Twenty-three older healthy controls and 25 adults with MCI underwent multimodal MRI scanning. Limbic white matter tracts-the fornix, parahippocampal cingulum, retrosplenial cingulum, subgenual cingulum and uncinate fasciculus-were reconstructed in ExploreDTI using constrained spherical deconvolution-based tractography. Using a network-of-interest approach, resting-state functional connectivity time-series correlations among sub-parcellations of the default mode and limbic networks, the hippocampus and the thalamus were calculated in Conn.
Controlling for age, education, and gender between group linear regressions of five diffusion-weighted measures and of resting state connectivity measures were performed per hemisphere. FDR-corrections were performed within each class of measures. Correlations of within-network Fisher Z-transformed correlation coefficients and the mean diffusivity per tract were performed. Whole-brain graph theory measures of cluster coefficient and average path length were inspecting using the resting state data.
MCI-related changes in white matter structure were found in the fornix, left parahippocampal cingulum, left retrosplenial cingulum and left subgenual cingulum. Functional connectivity decreases were observed in the MCI group within the DMN-a sub-network, between the hippocampus and sub-areas -a and -c of the DMN, between DMN-c and DMN-a, and, in the right hemisphere only between DMN-c and both the thalamus and limbic-a. No relationships between white matter tract 'integrity' (mean diffusivity) and within sub-network functional connectivity were found. Graph theory revealed that changes in the MCI group was mostly restricted to diminished between-neighbour connections of the hippocampi and of nodes within DMN-a and DMN-b.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0222977</identifier><identifier>PMID: 31581245</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aging ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Artificial neural networks ; Atrophy ; Attention deficit hyperactivity disorder ; Biology and Life Sciences ; Brain ; Care and treatment ; Cingulum ; Cognitive ability ; Computer and Information Sciences ; Control methods ; Correlation ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Dementia ; Diffusion Magnetic Resonance Imaging ; Diffusion rate ; Diffusivity ; Female ; Fornix ; Fornix, Brain - diagnostic imaging ; Fornix, Brain - physiopathology ; Graph theory ; Hemispheric laterality ; Hippocampus ; Humans ; Internet ; Magnetic resonance imaging ; Male ; Medicine ; Medicine and Health Sciences ; Memory ; Nerve Net - diagnostic imaging ; Nerve Net - physiopathology ; Neural networks ; Neuropsychological Tests ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Parahippocampal gyrus ; Physical Sciences ; Psychiatry ; Regression analysis ; Rest ; Risk factors ; Social Sciences ; Structure-function relationships ; Substantia alba ; Thalamus ; White Matter - diagnostic imaging ; White Matter - physiopathology</subject><ispartof>PloS one, 2019-10, Vol.14 (10), p.e0222977</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Gilligan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Gilligan et al 2019 Gilligan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1e0f640482957685210f1415ee840f9f19ffa32a7106db7665afe68a61982c083</citedby><cites>FETCH-LOGICAL-c692t-1e0f640482957685210f1415ee840f9f19ffa32a7106db7665afe68a61982c083</cites><orcidid>0000-0002-3589-701X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776361/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776361/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31581245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhang, Han</contributor><creatorcontrib>Gilligan, Therese M</creatorcontrib><creatorcontrib>Sibilia, Francesca</creatorcontrib><creatorcontrib>Farrell, Dervla</creatorcontrib><creatorcontrib>Lyons, Declan</creatorcontrib><creatorcontrib>Kennelly, Seán P</creatorcontrib><creatorcontrib>Bokde, Arun L W</creatorcontrib><title>No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The earliest changes in the brain due to Alzheimer's disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among regions that support memory function in prodromal Alzheimer's disease, i.e., during the mild cognitive impairment (MCI) stage.
Twenty-three older healthy controls and 25 adults with MCI underwent multimodal MRI scanning. Limbic white matter tracts-the fornix, parahippocampal cingulum, retrosplenial cingulum, subgenual cingulum and uncinate fasciculus-were reconstructed in ExploreDTI using constrained spherical deconvolution-based tractography. Using a network-of-interest approach, resting-state functional connectivity time-series correlations among sub-parcellations of the default mode and limbic networks, the hippocampus and the thalamus were calculated in Conn.
Controlling for age, education, and gender between group linear regressions of five diffusion-weighted measures and of resting state connectivity measures were performed per hemisphere. FDR-corrections were performed within each class of measures. Correlations of within-network Fisher Z-transformed correlation coefficients and the mean diffusivity per tract were performed. Whole-brain graph theory measures of cluster coefficient and average path length were inspecting using the resting state data.
MCI-related changes in white matter structure were found in the fornix, left parahippocampal cingulum, left retrosplenial cingulum and left subgenual cingulum. Functional connectivity decreases were observed in the MCI group within the DMN-a sub-network, between the hippocampus and sub-areas -a and -c of the DMN, between DMN-c and DMN-a, and, in the right hemisphere only between DMN-c and both the thalamus and limbic-a. No relationships between white matter tract 'integrity' (mean diffusivity) and within sub-network functional connectivity were found. Graph theory revealed that changes in the MCI group was mostly restricted to diminished between-neighbour connections of the hippocampi and of nodes within DMN-a and DMN-b.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Artificial neural networks</subject><subject>Atrophy</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Care and treatment</subject><subject>Cingulum</subject><subject>Cognitive ability</subject><subject>Computer and Information Sciences</subject><subject>Control methods</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Dementia</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Diffusion rate</subject><subject>Diffusivity</subject><subject>Female</subject><subject>Fornix</subject><subject>Fornix, Brain - diagnostic imaging</subject><subject>Fornix, Brain - physiopathology</subject><subject>Graph theory</subject><subject>Hemispheric laterality</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Internet</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Nerve Net - diagnostic imaging</subject><subject>Nerve Net - physiopathology</subject><subject>Neural networks</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Parahippocampal gyrus</subject><subject>Physical Sciences</subject><subject>Psychiatry</subject><subject>Regression analysis</subject><subject>Rest</subject><subject>Risk factors</subject><subject>Social Sciences</subject><subject>Structure-function relationships</subject><subject>Substantia alba</subject><subject>Thalamus</subject><subject>White Matter - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilligan, Therese M</au><au>Sibilia, Francesca</au><au>Farrell, Dervla</au><au>Lyons, Declan</au><au>Kennelly, Seán P</au><au>Bokde, Arun L W</au><au>Zhang, Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-10-03</date><risdate>2019</risdate><volume>14</volume><issue>10</issue><spage>e0222977</spage><pages>e0222977-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The earliest changes in the brain due to Alzheimer's disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among regions that support memory function in prodromal Alzheimer's disease, i.e., during the mild cognitive impairment (MCI) stage.
Twenty-three older healthy controls and 25 adults with MCI underwent multimodal MRI scanning. Limbic white matter tracts-the fornix, parahippocampal cingulum, retrosplenial cingulum, subgenual cingulum and uncinate fasciculus-were reconstructed in ExploreDTI using constrained spherical deconvolution-based tractography. Using a network-of-interest approach, resting-state functional connectivity time-series correlations among sub-parcellations of the default mode and limbic networks, the hippocampus and the thalamus were calculated in Conn.
Controlling for age, education, and gender between group linear regressions of five diffusion-weighted measures and of resting state connectivity measures were performed per hemisphere. FDR-corrections were performed within each class of measures. Correlations of within-network Fisher Z-transformed correlation coefficients and the mean diffusivity per tract were performed. Whole-brain graph theory measures of cluster coefficient and average path length were inspecting using the resting state data.
MCI-related changes in white matter structure were found in the fornix, left parahippocampal cingulum, left retrosplenial cingulum and left subgenual cingulum. Functional connectivity decreases were observed in the MCI group within the DMN-a sub-network, between the hippocampus and sub-areas -a and -c of the DMN, between DMN-c and DMN-a, and, in the right hemisphere only between DMN-c and both the thalamus and limbic-a. No relationships between white matter tract 'integrity' (mean diffusivity) and within sub-network functional connectivity were found. Graph theory revealed that changes in the MCI group was mostly restricted to diminished between-neighbour connections of the hippocampi and of nodes within DMN-a and DMN-b.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31581245</pmid><doi>10.1371/journal.pone.0222977</doi><tpages>e0222977</tpages><orcidid>https://orcid.org/0000-0002-3589-701X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2019-10, Vol.14 (10), p.e0222977 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2300607239 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Aging Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer's disease Artificial neural networks Atrophy Attention deficit hyperactivity disorder Biology and Life Sciences Brain Care and treatment Cingulum Cognitive ability Computer and Information Sciences Control methods Correlation Correlation analysis Correlation coefficient Correlation coefficients Dementia Diffusion Magnetic Resonance Imaging Diffusion rate Diffusivity Female Fornix Fornix, Brain - diagnostic imaging Fornix, Brain - physiopathology Graph theory Hemispheric laterality Hippocampus Humans Internet Magnetic resonance imaging Male Medicine Medicine and Health Sciences Memory Nerve Net - diagnostic imaging Nerve Net - physiopathology Neural networks Neuropsychological Tests Neurosciences NMR Nuclear magnetic resonance Parahippocampal gyrus Physical Sciences Psychiatry Regression analysis Rest Risk factors Social Sciences Structure-function relationships Substantia alba Thalamus White Matter - diagnostic imaging White Matter - physiopathology |
| title | No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer's disease |
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