Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by compa...
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| description | Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p |
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The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p<0.001), undifferentiated type (38.0 vs. 19.6%, p<0.001), tumor size (29.5 ±19.4 vs. 20.3 ±16.8 mm, p<0.001) and submucosal (SM) invasion (60.9 vs. 25.7%, p<0.001) were significantly higher in the proximal group than in the distal group. In multivariate analysis, the proximal location of EGC was a significant risk factor for SM invasion in the total population (odds ratio [OR], 3.541; 95% confidence interval [CI], 2.053-6.110; p<0.001), and in subgroup with EGC < 30mm (n = 279) (OR, 5.940; 95% CI, 2.974-11.862; p<0.001). In conclusion, careful therapeutic decision of proximal EGC is essential due to the different histopathological characteristics such as large tumor size and higher potential for SM invasion.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0223284</identifier><identifier>PMID: 31560720</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Biology and Life Sciences ; Cancer ; Cancer research ; Care and treatment ; Clinical Decision-Making ; Confidence intervals ; Diagnosis ; Dissection ; Early Detection of Cancer ; Endoscopic Mucosal Resection ; Endoscopy ; Female ; Gastrectomy ; Gastric cancer ; Gastric Mucosa - diagnostic imaging ; Gastric Mucosa - pathology ; Gastric Mucosa - surgery ; Gastroenterology ; Gastroscopy ; Hospitals ; Humans ; Internal medicine ; Male ; Medical schools ; Medicine ; Medicine and Health Sciences ; Metastasis ; Middle Aged ; Multivariate analysis ; Neoplasm Invasiveness - diagnostic imaging ; Neoplasm Invasiveness - pathology ; Patient outcomes ; Patient Selection ; Patients ; Retrospective Studies ; Risk analysis ; Risk Factors ; Statistics (Mathematics) ; Stomach cancer ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Studies ; Subgroups ; Surgery ; Tumor Burden ; Tumors ; Ultrasonic imaging</subject><ispartof>PloS one, 2019-09, Vol.14 (9), p.e0223284-e0223284</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Koh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Koh et al 2019 Koh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-813138dd57f1d59a20560472b611bdbe0db9d6cec3c4c8eba0cb870ce38c872e3</citedby><cites>FETCH-LOGICAL-c585t-813138dd57f1d59a20560472b611bdbe0db9d6cec3c4c8eba0cb870ce38c872e3</cites><orcidid>0000-0001-6050-3695</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764682/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764682/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31560720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, Jin Sung</creatorcontrib><creatorcontrib>Joo, Moon Kyung</creatorcontrib><creatorcontrib>Park, Jong-Jae</creatorcontrib><creatorcontrib>Lee, Beom Jae</creatorcontrib><creatorcontrib>Chun, Hoon Jai</creatorcontrib><creatorcontrib>Lee, Sang Woo</creatorcontrib><creatorcontrib>Jang, You-Jin</creatorcontrib><creatorcontrib>Mok, Young-Jae</creatorcontrib><title>Characteristics of proximal early gastric cancer differentiating distal early gastric cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p<0.001), undifferentiated type (38.0 vs. 19.6%, p<0.001), tumor size (29.5 ±19.4 vs. 20.3 ±16.8 mm, p<0.001) and submucosal (SM) invasion (60.9 vs. 25.7%, p<0.001) were significantly higher in the proximal group than in the distal group. In multivariate analysis, the proximal location of EGC was a significant risk factor for SM invasion in the total population (odds ratio [OR], 3.541; 95% confidence interval [CI], 2.053-6.110; p<0.001), and in subgroup with EGC < 30mm (n = 279) (OR, 5.940; 95% CI, 2.974-11.862; p<0.001). In conclusion, careful therapeutic decision of proximal EGC is essential due to the different histopathological characteristics such as large tumor size and higher potential for SM invasion.]]></description><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Care and treatment</subject><subject>Clinical Decision-Making</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Dissection</subject><subject>Early Detection of Cancer</subject><subject>Endoscopic Mucosal Resection</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastric cancer</subject><subject>Gastric Mucosa - diagnostic imaging</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastric Mucosa - surgery</subject><subject>Gastroenterology</subject><subject>Gastroscopy</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoplasm Invasiveness - diagnostic imaging</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Patient outcomes</subject><subject>Patient Selection</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Statistics (Mathematics)</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Surgery</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1kt-LEzEQxxdRvPP0PxBdEMSX1vzabPIiHOXUgwNf9E0Is8lsm5JuarIV77-_9Lp3tKJPmSSf-c58h6mq15TMKW_px3XcpQHCfBsHnBPGOFPiSXVONWczyQh_ehSfVS9yXhPScCXl8-qM00aSlpHz6udiBQnsiMnn0dtcx77epvjHbyDUCCnc1kvIY_K2tjBYTLXzfY8Jh9HD6IdluefxP-zL6lkPIeOr6byofny--r74Orv59uV6cXkzs41qxpminHLlXNP21DUaGCndiZZ1ktLOdUhcp520aLkVVmEHxHaqJRa5sqplyC-qtwfdbYjZTIPJhjGtlORakEJcHwgXYW22qdhLtyaCN_cPMS0NpOI_oBHaUcmA6x5BcNQdihI4aDpNGBGuaH2aqu26DTpbRpEgnIie_gx-ZZbxt5GtFFKxIvBhEkjx1w7zaDY-WwwBBoy7-741FVwIUdB3f6H_djdRSygG_NDHUtfuRc2lJEQrrRpZqPdH1AohjKscw270ccinoDiANsWcE_aP3igx-917aMLsd89Mu1fS3hzP5THpYdn4HfNK1-s</recordid><startdate>20190927</startdate><enddate>20190927</enddate><creator>Koh, Jin Sung</creator><creator>Joo, Moon Kyung</creator><creator>Park, Jong-Jae</creator><creator>Lee, Beom Jae</creator><creator>Chun, Hoon Jai</creator><creator>Lee, Sang Woo</creator><creator>Jang, You-Jin</creator><creator>Mok, Young-Jae</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6050-3695</orcidid></search><sort><creationdate>20190927</creationdate><title>Characteristics of proximal early gastric cancer differentiating distal early gastric cancer</title><author>Koh, Jin Sung ; Joo, Moon Kyung ; Park, Jong-Jae ; Lee, Beom Jae ; Chun, Hoon Jai ; Lee, Sang Woo ; Jang, You-Jin ; Mok, Young-Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-813138dd57f1d59a20560472b611bdbe0db9d6cec3c4c8eba0cb870ce38c872e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Care and treatment</topic><topic>Clinical Decision-Making</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Dissection</topic><topic>Early Detection of Cancer</topic><topic>Endoscopic Mucosal Resection</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastric cancer</topic><topic>Gastric Mucosa - diagnostic imaging</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastric Mucosa - surgery</topic><topic>Gastroenterology</topic><topic>Gastroscopy</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Male</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neoplasm Invasiveness - diagnostic imaging</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Patient outcomes</topic><topic>Patient Selection</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Statistics (Mathematics)</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Surgery</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koh, Jin Sung</creatorcontrib><creatorcontrib>Joo, Moon Kyung</creatorcontrib><creatorcontrib>Park, Jong-Jae</creatorcontrib><creatorcontrib>Lee, Beom Jae</creatorcontrib><creatorcontrib>Chun, Hoon Jai</creatorcontrib><creatorcontrib>Lee, Sang Woo</creatorcontrib><creatorcontrib>Jang, You-Jin</creatorcontrib><creatorcontrib>Mok, Young-Jae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koh, Jin Sung</au><au>Joo, Moon Kyung</au><au>Park, Jong-Jae</au><au>Lee, Beom Jae</au><au>Chun, Hoon Jai</au><au>Lee, Sang Woo</au><au>Jang, You-Jin</au><au>Mok, Young-Jae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of proximal early gastric cancer differentiating distal early gastric cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-09-27</date><risdate>2019</risdate><volume>14</volume><issue>9</issue><spage>e0223284</spage><epage>e0223284</epage><pages>e0223284-e0223284</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p<0.001), undifferentiated type (38.0 vs. 19.6%, p<0.001), tumor size (29.5 ±19.4 vs. 20.3 ±16.8 mm, p<0.001) and submucosal (SM) invasion (60.9 vs. 25.7%, p<0.001) were significantly higher in the proximal group than in the distal group. In multivariate analysis, the proximal location of EGC was a significant risk factor for SM invasion in the total population (odds ratio [OR], 3.541; 95% confidence interval [CI], 2.053-6.110; p<0.001), and in subgroup with EGC < 30mm (n = 279) (OR, 5.940; 95% CI, 2.974-11.862; p<0.001). In conclusion, careful therapeutic decision of proximal EGC is essential due to the different histopathological characteristics such as large tumor size and higher potential for SM invasion.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31560720</pmid><doi>10.1371/journal.pone.0223284</doi><orcidid>https://orcid.org/0000-0001-6050-3695</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| subjects | Aged Biology and Life Sciences Cancer Cancer research Care and treatment Clinical Decision-Making Confidence intervals Diagnosis Dissection Early Detection of Cancer Endoscopic Mucosal Resection Endoscopy Female Gastrectomy Gastric cancer Gastric Mucosa - diagnostic imaging Gastric Mucosa - pathology Gastric Mucosa - surgery Gastroenterology Gastroscopy Hospitals Humans Internal medicine Male Medical schools Medicine Medicine and Health Sciences Metastasis Middle Aged Multivariate analysis Neoplasm Invasiveness - diagnostic imaging Neoplasm Invasiveness - pathology Patient outcomes Patient Selection Patients Retrospective Studies Risk analysis Risk Factors Statistics (Mathematics) Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - pathology Stomach Neoplasms - surgery Studies Subgroups Surgery Tumor Burden Tumors Ultrasonic imaging |
| title | Characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T21%3A47%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristics%20of%20proximal%20early%20gastric%20cancer%20differentiating%20distal%20early%20gastric%20cancer&rft.jtitle=PloS%20one&rft.au=Koh,%20Jin%20Sung&rft.date=2019-09-27&rft.volume=14&rft.issue=9&rft.spage=e0223284&rft.epage=e0223284&rft.pages=e0223284-e0223284&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0223284&rft_dat=%3Cgale_plos_%3EA600989856%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2298863940&rft_id=info:pmid/31560720&rft_galeid=A600989856&rft_doaj_id=oai_doaj_org_article_49d162a39fea43e9be4ea4da5b90204d&rfr_iscdi=true |