Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers

Positron emission tomography (PET) imaging of macrophages using the translocator protein (TSPO) tracer (R)-[11C]PK11195 has shown the promise to image rheumatoid arthritis (RA). To further improve TSPO PET for RA imaging, second generation TSPO tracers [11C]DPA-713 and [18F]DPA-714 have recently bee...

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Veröffentlicht in:	PloS one 2019-09, Vol.14 (9), p.e0222844-e0222844
Hauptverfasser:	Bruijnen, S T G, Verweij, N J F, Gent, Y Y J, Huisman, M C, Windhorst, A D, Kassiou, M, van de Ven, P M, Lammertsma, A A, Hoekstra, O S, Voskuyl, A E, van der Laken, C J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amides Arthritis Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - diagnosis Autoimmune diseases Biology and Life Sciences Care and treatment Computed tomography Diagnosis Early Diagnosis Emissions Female Fluorine isotopes Genetic aspects Good Manufacturing Practice Hand Joints - cytology Hand Joints - diagnostic imaging Humans Immunology Isoquinolines Joint diseases Joints (anatomy) Ligands Macrophages Macrophages - metabolism Male Medical imaging Medicine and Health Sciences Middle Aged Molecular Imaging - methods Nuclear medicine Patients Polymorphism Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography - methods Proof of Concept Study Proteins Pyrazoles - pharmacology Pyrimidines - pharmacology Radiopharmaceuticals - pharmacology Receptors, GABA - metabolism Research and Analysis Methods Rheumatoid arthritis Rheumatoid factor Rheumatology Sport utility vehicles Studies Tomography Tracers Tracers (Biology) Translocations (Genetics)
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