Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation

To investigate cerebral microstructural alterations in patients treated with calcineurin inhibitors (CNI) after orthotopic liver transplantation (OLT) using quantitative magnetic resonance imaging (qMRI) and a cross-sectional study design. Cerebral qMRI was performed in 85 patients in a median 10 ye...

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Veröffentlicht in:	PloS one 2019-09, Vol.14 (9), p.e0222934
Hauptverfasser:	Goede, Lukas Laurids, Pflugrad, Henning, Schmitz, Birte, Lanfermann, Heinrich, Tryc, Anita Blanka, Barg-Hock, Hannelore, Klempnauer, Jürgen, Weissenborn, Karin, Ding, Xiao-Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Anisotropy Biology and Life Sciences Brain Brain research Calcineurin Calcineurin inhibitors Calcineurin Inhibitors - adverse effects Cardiovascular disease Cross-Sectional Studies Diagnostic imaging Diffusion coefficient Diffusion Tensor Imaging Dosage Edema Everolimus Female Fibers Free water Graft Rejection - immunology Graft Rejection - prevention & control Gray Matter - diagnostic imaging Gray Matter - drug effects Health aspects Humans Immunosuppression Immunosuppression - adverse effects Immunosuppression - methods Immunosuppressive agents Immunotherapy Liver Liver transplantation Liver Transplantation - adverse effects Liver transplants Magnetic resonance Magnetic resonance imaging Male Medical imaging Medical research Medical schools Medicine and Health Sciences Metabolism Metabolites Methods Middle Aged Neuroimaging Neurology Neurons Neurotoxicity NMR Nuclear magnetic resonance Organ transplantation Physical Sciences Quantitative psychology Research and Analysis Methods Resonance Side effects Substantia alba Surgery Transplantation Transplants & implants White Matter - diagnostic imaging White Matter - drug effects
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