Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules

The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle composed of smooth peripheral tubules and rough, ribosome-studded central ER sheets whose morphology is determined, in part, by the ER-shaping proteins, reticulon (RTN) and cytoskeleton-linking membrane protein 63 (CLIMP-63)...

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Veröffentlicht in:	PLoS biology 2019-08, Vol.17 (8), p.e3000355-e3000355
Hauptverfasser:	Gao, Guang, Zhu, Chengjia, Liu, Emma, Nabi, Ivan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biology and Life Sciences Calnexin Calreticulin Cell adhesion & migration Cell Line, Tumor Chlorocebus aethiops Confocal microscopy COS Cells Cytoskeleton Cytoskeleton - metabolism Depletion Endoplasmic reticulum Endoplasmic Reticulum - metabolism Fluorescence Green fluorescent protein Heterogeneity Humans Lipids Localization Membrane proteins Membrane Proteins - metabolism Membranes - metabolism Microscopy Microtubules - metabolism Morphology Nogo Proteins - metabolism Nonlinear Optical Microscopy - methods Oxidation Physiological aspects Physiology Proteins Research and Analysis Methods Signal transduction Stimulated emission Structure Tubules
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