Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome
The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development....
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| Veröffentlicht in: | PLoS genetics 2019-08, Vol.15 (8), p.e1008236 |
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| creator | Vlahos, Amanda Mansell, Toby Saffery, Richard Novakovic, Boris |
| description | The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and its role in mediating maternal-fetal exchange that leaves it open to a range of exogenous exposures in the maternal circulation. In this review, we cover recent advances in DNA methylation in the context of placental function and development, as well as the interaction between the pregnancy and the environment. |
| doi_str_mv | 10.1371/journal.pgen.1008236 |
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In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and its role in mediating maternal-fetal exchange that leaves it open to a range of exogenous exposures in the maternal circulation. In this review, we cover recent advances in DNA methylation in the context of placental function and development, as well as the interaction between the pregnancy and the environment.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1008236</identifier><identifier>PMID: 31369552</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Autism ; Biology and life sciences ; Chemokines ; Deoxyribonucleic acid ; DNA ; DNA methylation ; DNA Methylation - physiology ; Environmental aspects ; Environmental Exposure - adverse effects ; Environmental toxicology ; Epigenesis, Genetic - physiology ; Epigenetic inheritance ; Epigenetics ; Epigenome - physiology ; Female ; Fetal development ; Fetuses ; Gene expression ; Genetic aspects ; Health aspects ; Hormones ; Hormones - metabolism ; Humans ; Ligands ; Maternal Exposure - adverse effects ; Maternal-Fetal Exchange - genetics ; Medicine and Health Sciences ; Menopause ; Methylation ; Observations ; Physiological aspects ; Placenta ; Placenta - cytology ; Placenta - physiology ; Placentation - genetics ; Preeclampsia ; Pregnancy ; Pregnancy Outcome ; Pregnant women ; Review ; Single-Cell Analysis</subject><ispartof>PLoS genetics, 2019-08, Vol.15 (8), p.e1008236</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Vlahos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In this review, we cover recent advances in DNA methylation in the context of placental function and development, as well as the interaction between the pregnancy and the environment.</description><subject>Autism</subject><subject>Biology and life sciences</subject><subject>Chemokines</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA Methylation - physiology</subject><subject>Environmental aspects</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental toxicology</subject><subject>Epigenesis, Genetic - physiology</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Epigenome - physiology</subject><subject>Female</subject><subject>Fetal development</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Hormones - metabolism</subject><subject>Humans</subject><subject>Ligands</subject><subject>Maternal Exposure - adverse effects</subject><subject>Maternal-Fetal Exchange - genetics</subject><subject>Medicine and Health Sciences</subject><subject>Menopause</subject><subject>Methylation</subject><subject>Observations</subject><subject>Physiological aspects</subject><subject>Placenta</subject><subject>Placenta - cytology</subject><subject>Placenta - physiology</subject><subject>Placentation - genetics</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnant women</subject><subject>Review</subject><subject>Single-Cell 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| subjects | Autism Biology and life sciences Chemokines Deoxyribonucleic acid DNA DNA methylation DNA Methylation - physiology Environmental aspects Environmental Exposure - adverse effects Environmental toxicology Epigenesis, Genetic - physiology Epigenetic inheritance Epigenetics Epigenome - physiology Female Fetal development Fetuses Gene expression Genetic aspects Health aspects Hormones Hormones - metabolism Humans Ligands Maternal Exposure - adverse effects Maternal-Fetal Exchange - genetics Medicine and Health Sciences Menopause Methylation Observations Physiological aspects Placenta Placenta - cytology Placenta - physiology Placentation - genetics Preeclampsia Pregnancy Pregnancy Outcome Pregnant women Review Single-Cell Analysis |
| title | Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome |
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