A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure

The NAD+-dependent histone deacetylase Sir2 was originally identified in Saccharomyces cerevisiae as a silencing factor for HML and HMR, the heterochromatic cassettes utilized as donor templates during mating-type switching. MATa cells preferentially switch to MATα using HML as the donor, which is d...

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Veröffentlicht in:	PLoS genetics 2019-08, Vol.15 (8), p.e1008339-e1008339
Hauptverfasser:	Li, Mingguang, Fine, Ryan D, Dinda, Manikarna, Bekiranov, Stefan, Smith, Jeffrey S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Binding sites Biochemistry Biology and Life Sciences Chromatin Chromosome 3 Chromosome III Chromosomes Chromosomes, Fungal - genetics Condensin Deoxyribonucleic acid DNA DNA-Binding Proteins - metabolism Endonuclease Gene expression Genes Genes, Mating Type, Fungal - genetics Genetic aspects Genetic Loci - genetics Genomes Genomics Histone deacetylase Histones HO endonuclease Locus Control Region - genetics Medicine Multiprotein Complexes - metabolism NAD Novels Nucleases Physiological aspects Promoter Regions, Genetic - genetics Proteins Recombination Recombination, Genetic Research and Analysis Methods Saccharomyces Saccharomyces cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 2 - genetics Sirtuin 2 - metabolism Stem cells Structure Transcription Yeast
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